丁澦

基本信息

职称:副教授
电话:021-31246545
邮箱:yuding@fudan.edu.cn
地址:复旦大学生命科学学院 A201-5室

 

个人简介

男,1978年出生,博士,副教授。1996-1999年就读于复旦大学生命科学学院理科基地班,获学士学位;1999-2004年就读于复旦大学生命科学学院生理学和生物物理学系生物物理学专业(硕博连读),获理学博士学位。2004年认定为讲师,2007年晋升副教授。20092月至20119月先后以Research AssociateResearch Assistant Professor交流至香港大学化学系。

 

主要研究方向 (Research Interests)

结构生物学,化学生物学

通过结构生物学和化学生物学方法,研究神经退行性疾病相关靶蛋白与治疗性小分子及纳米抗体之间的作用机制,并开发相应的高灵敏特异性靶蛋白检测技术。

 

获奖情况 (Awards)

2009年指导本科生陈闻涛,陆致晟和吴旭冬获第11挑战杯全国特等奖并获优秀指导教师奖

2015年度复旦大学2015届本(专)科毕业生我心目中的好老师

多次获复星奖教金、复华奖教金等

 

代表性成果

1. H. Zhao, J. Zhao, J. Hou, S. Wang, Y. Ding*, B. Lu*, and J. Wang*, AlphaLISA detection of alpha-synuclein in the cerebrospinal fluid and its potential application in Parkinson's disease diagnosis. Protein Cell, 2017. 8(9):696-700.

2. J. Zhao, L. Xu, Q. Liang, Q. Sun, C. Chen, Y. Zhang, Y. Ding Y. Ding*, and P. Zhou*, EGCG attenuates Fe(III)-induced conformational transition of alpha-synuclein and protects AS-PC12 cells against Fe(III)-induced death. J Neurochem, 2017. 143(1):136-146.

3. R. Liu, X.J. Hu*, and Y. Ding*, Rational design of a pH-insensitive cyan fluorescent protein CyPet2 based on the CyPet crystal structure. FEBS Lett, 2017. 591(12): p. 1761-1769.

4. J. Zhao, Q. Liang, Q. Sun, C. Chen, L. Xu, Y. Ding*, and P. Zhou*, (−)-Epigallocatechin-3-gallate (EGCG) inhibits fibrillation, disaggregates amyloid fibrils of α-synuclein, and protects PC12 cells against α-synuclein-induced toxicity. RSC Adv, 2017. 7: p. 32508-32517 (12): p. 1761-176.

5. Liu, R., G. Yang, M.H. Zhou, Y. He, Y.A. Mei*, and Y. Ding*, Flotillin-1 downregulates K+ current by directly coupling with Kv2.1 subunit. Protein Cell, 2016. 7(6): p. 455-460.

6. Liu, R., Q.N. Liang, S.Q. Du, X.J. Hu*, and Y. Ding*, The crystal structure of red fluorescent protein TagRFP-T reveals the mechanism of its superior photostability. Biochem. Biophys. Res. Commun., 2016. 477(2): p. 229-234.

7. Liang, Q.N., R. Liu, S.Q. Du, and Y. Ding*, Structural insights on the catalytic site protection of human carbonyl reductase 1 by glutathione. J. Struct. Biol., 2015. 192(1): p. 138-144.

8. Cui, X.T., Q.N. Liang, Y.J. Liang, M.X. Lu, Y. Ding*, and B.X. Lu*, TR-FRET Assays of Huntingtin Protein Fragments Reveal Temperature and PolyQ Length-Dependent Conformational Changes. Sci Rep, 2014. 4.

9. Sun, P.F., Y. He, M.C. Lin, Y. Zhao, Y. Ding*, G.S. Chen*, and M. Jiang, Glyco-regioisomerism Effect on Lectin-Binding and Cell-Uptake Pathway of Glycopolymer-Containing Nanoparticles. ACS Macro Lett., 2014. 3(1): p. 96-101.

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