甘建华

基本信息

职称:教授
电话:021-516
30543
邮箱:ganjhh@fudan.edu.cn
地址:复旦大学生命科学学院 A201-7室

 

个人简介

男,研究员,博导。1997年获北京医科大学药物化学学士学位,2002年获中国科学院上海有机化学研究所有机化学博士学位。2003-2012年间先后以Postdoctoral Fellow,Research Associate 和Research Scientist 身份在美国国立卫生院(NIH)下属的癌症研究中心(NCI),美国纽约纪念斯隆凯特琳癌症中心及美国佐治亚州立大学进行研究。2012年9月受聘复旦大学生命科学学院研究员。

 

主要研究方向 (Research Interests)

以X-射线晶体学为主要手段,结合其他生物物理和生物化学方法研究生物大分子的结构和功能。主要包括:(1)RNA沉默通路中的核糖核酸酶的作用机制研究;(2)DNA复制和修复酶的结构和作用机制研究;3)具有催化功能的核酸分子的结构研究。

 

获奖情况 (Awards)

(1)获The SER-CAT Young Investigator Award (the Southeast Regional Collaborative Access Team,SER-CAT), USA, 2006.
(2)获FARE Award (The Fellows Award for Research Excellence, NIH), USA, 2007.
(3)获STTR Grant, USA, 2010-2011

 

 

代表性成果

1. Yu X, Li XH, Zheng LN, Ma JB*, Gan JH*. (2017) Structural and functional studies of a noncanonical Dicer from Entamoeba histolytica, Scientific Reports (in press).

2. Chen YQ, Zhang J, Liu HH, Gao YQ, Li,XH, Zheng LN, Cui RX, Yao QQ, Rong L, Li JX, Huang Z*, Ma JB*, Gan JH*. (2017) Unique 5'-P recognition and basis for dG:dGTP misincorporation of ASFV DNA polymerase X,Plos Biology,15(2): e1002599.

3. Kang HP#Gan JH#, Zhao JR#,Kong WN,Zhang J,Zhu M,Li F,Song YQ,Qin J,Liang HH*,(2017) Crystal structure of Pseudomonas aeruginosa RsaL bound to promoter DNA reaffirms its role as a global regulator involved in quorum-sensing,Nucleic Acids Res.,45(2):699-710.

4. Zhang J,Liu HH,Yao QQ,Yu X,Chen YQ,Cui RX,Wu BX,Zheng LN,Zuo JJ,Huang Z*, Ma JB*, Gan JH*. (2016) Structural basis for single-stranded RNA recognition and cleavage by C3PO,Nucleic Acids Res.,44(19):9494-9504.

5. Liu HH#,Cai C#,Haruehanroengra P,Yao QQ,Chen YQ,Yang C,Luo Q,Wu BX,Li JX,Ma JB*,Sheng J*,Gan JH*. (2016) Flexibility and stabilization of HgII-mediated C:T and T:T base pairs in DNA duplex,Nucleic Acids Res.,Epub ahead of print. doi: 10.1093/nar/gkw1296.

6. Shen FS#, Luo ZP#,Liu HH,Wang R,Zhang SL, Gan JH*,Sheng J*. (2016) Structural insights into RNA duplexes with multiple 2'-5'-linkages,Nucleic Acids Res.,Epub ahead of print. doi: 10.1093/nar/gkw1307.

7. Zhao JR#, Yu X#,Zhu M,Kang HP,Ma JB,Wu M,Gan JH*,Deng X*,Liang HH*,(2016) Structural and Molecular Mechanism of CdpR Involved in Quorum-Sensing and Bacterial Virulence in Pseudomonas aeruginosa,PLoS Biology,14(4): e1002449.

8. Court DL*, Gan JH, Liang YH, Shaw GX, Tropea JE, Costantino N, Waugh DS, Ji X*, (2013) RNase III: Genetics and Function; Structure and Mechanism, Annu. Rev. Genet. (invited and peer reviewed), 47, 405-431.

9. Gan JH, Shaw GX, Tropea JE, Waugh DS, Court DL, Ji X*, (2008) A Stepwise Model for Double-Stranded RNA Processing by Ribonuclease III, Mol. Microbiol., 67, 143-154.

10. Gan JH, Tropea JE, Austin BP, Court DL, Waugh DS, Ji X*, (2006) Structural Insight into the Mechanism of Double-Stranded RNA Processing by Ribonuclease III, Cell, 124(2): 355–366.

 

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