霍克克

基本信息

职称:教授
电话:021-516
30562
邮箱:kkhuo@fudan.edu.cn
地址:复旦大学生命科学学院 D513室

 

个人简介

男,1952年出生,博士,教授。1993年7月于复旦大学生命科学学院遗传学专业博士研究生毕业,同年留校在遗传工程国家重点实验室从事遗传学和遗传工程的教学与科研工作至今。

 

 

主要研究方向 (Research Interests)

酵母分子生物学与基因工程,研发异源重组蛋白在酵母中的高表达系统。以酵母为模式生物进行人类、植物和病原微生物的基因与蛋白质功能研究,侧重于疾病相关基因和蛋白质的功能及其相互作用,并以酵母为模型进行药物有效成分和药物作用靶点的筛选研究。

专利与药证 (Patents and Drug Certificates)
《肿瘤抑制基因及其编码蛋白和应用》专利号:ZL 03129412.X;《脆壁克鲁维酵母高效转化系统》专利号:ZL 97106403.2;新药证书《注射用重组人干扰素α b(酵母)》国药证字S20010042;新药证书《注射用重组人干扰素α 2a(酵母)》国药证字(2000)S-55。

 

获奖情况 (Awards)

 

 

代表性成果

1.  Yan J, Di YJ, Shi HL, Rao H*,Huo KK*. (2010). Overexpression of SCYL1-BP1 can stabilize functional p53 by suppressing MDM2-mediated ubiquitination.  FEBS Letters  584 (20): 4319-4324.

2.  Yan J, Zhang D, Di YJ, Shi HL, Rao H*,Huo KK*.(2010). A New Identified Pirh2 substrate SCYL1-BP1 can bind to MDM2 and accelerate MDM2 self-ubiquitination. FEBS Letters  584 (15): 3275-3278.

3.  Wu G, Sun MQ, Zhang LP, Zhou J, Wang Y, Huo KK*.(2010). A novel hPirh2 splicing variant without ubiquitin protein ligase activity interacts with p53 and is down-regulated in hepatocellular carcinoma. FEBS Letters  584 (13): 2772-2778.

4.  Wang W, Han GH, Ye ML, Shi HL, Zou HF* and Huo KK*.(2010). Mapping of phosphorylation sites in human MSK1 activated by a novel interaction with MRKβ using multiple stage mass spectrometric analysis with a Target-Decoy database search  Electrophoresis. 31:1283-1293.

5.  Wan B, Zhou YB, Zhang X, Zhu H, Huo K*, Han ZG*. (2008) hOLFML1, a novel secreted glycoprotein, enhances the proliferation of human cancer cell lines in vitro FEBS Letters. 582(21-22): 3185-3192.

6.  Ma Q, Zhou L, Shi HL, Huo KK*.(2008). NUMBL interacts with TAB2 and inhibits TNFalpha and IL-1beta-induced NF-kappaB activation. Cellular Signalling. 20(8): 1044-1051.

7.  Xie H, Pan SL, Liu S, Ye K, Huo KK*.(2007). A novel method of protein extraction from perennial Bupleurum root for 2-DE. Electrophoresis. 28: 871-5.

8.  Ma Q, Zhou L, Ma LX, Huo KK*.(2006). Directional and direct cloning strategy for high-throughput generation of recombinant baculoviruses. Biotechniques. 41(4):453-8.

9.  Xu ZG, Du JJ, Zhang X, Cheng ZH, Ma ZZ, Xiao HS, Yu L, Wang ZQ, Li YY, Huo KK*, Han ZG*. A novel liver-specific zona pellucida domain containing protein that is expressed rarely in hepatocellular carcinoma. Hepatology. 2003, 38 (3):735-44.

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