唐惠儒

基本信息

职称:教授
电话:021-31246
725
邮箱:huiru_tang@fudan.edu.cn

地址:复旦大学生命科学学院 D105室

 

个人简介

男,1966年生,国家杰出青年科学基金获得者、英国皇家化学会会士、复旦大学特聘教授。1986年获西北轻工业学院(现陕西科技大学)学士学位,1994年获伦敦大学博士学位。1992-2000年英国BBSRC食品研究所Research Scientist、Senior Scientist。2001-05年英国帝国理工学院生物医学部Senior Scientist。2005-14年中科院武汉物数所研究员、博士生导师、研究部副主任、中科院生物磁共振分析重点实验室主任。2014年加盟复旦大学生命科学学院。曾任英国NHS、科技部973及蛋白质重大计划等评审专家、J Proteome Res编委。在Nature等上发表SCI论文180余篇,被引7千余次。获批发明专利4项。部分工作被Science、Nature等作为“研究亮点”专文评述。现任中国生物物理学会理事、代谢组学分会会长、自由基生物学及医学分会常务理事、生物磁共振专委会委员,中国抗癌协会肿瘤代谢专业委员会常务理事,中国营养学会基础营养学分会理事,Metabolomics、Curr Metabolomics、Arch Pharm和《基础医学与临床》等编委,Nutrition & Metabolism等副主编。

Personal website: http://www.metabolome.cn/

 

主要研究方向 (Research Interests)

研究代谢物结构与功能30年,正发展高通量超灵敏代谢组学技术、代谢组与转录组/蛋白质组/微生物组等数据整合技术,研究肥胖等重大疾病发生发展的代谢组基础。曾主持完成国家杰出青年科学基金、肥胖等973项目课题多项。现承担国家重点研发计划、国家自然科学基金重大项目、国家创新群体、市级重大专项等课题。

 

获奖情况 (Awards)

英国皇家化学会会士(2005)、国家杰出青年科学基金(2008)、“新世纪百千万人才工程”国家级人选称号(2009)、王天眷波谱学奖(2010)、武汉市优秀科技工作者(2011)。

 

近3年代表性论文(通讯作者)

1. J.H. Xue, et al, “A vitamin-C-derived DNA modification catalysed by an algal TET homologue”, Nature, 569:581–585, 2019.

2. C.X. Liu, et al, “Metabolic changes of Fusarium graminearum induced by TPS gene deletion”. J Proteome Res, doi.org/10.1021/acs.jproteome.9b00259, 2019

3. H. Lin, et al, “Alterations of bile acids and gut microbiota in obesity induced by high fat diet in rat mode”, J Agric Food Chem, 67:3624-3632. 2019

4. L.M. Zhang, et al, “Metabolomics reveals that dietary ferulic acid and quercetin modulate metabolic homeostasis in rats”, J Agric Food Chem, 66, 1723−1731, 2018

5. J.B. Gou, et al, “Discovery of a non-stereoselective cytochrome P450 catalyzing either 8α- or 8β- hydroxylation of germacrene A acid from the Chinese medicinal plant, Inula hupehensis”, Plant J, 93:92-106, 2018.

6. F.F. Chen, et al, “Combined metabonomic and quantitative RT-PCR analyses revealed metabolic reprogramming associated with Fusarium graminearum resistance in transgenic Arabidopsis thaliana”, Frontiers Plant Science, 8:2177, 2018.

7. X.C. He, et al “Influence of genotype and environment on volatile profile of Valerianae jatamansi Rhizoma et Radix”, Front Plant Sci, 9:1003, 2018.

8. Q. Wang, et al, “Interspecies developmental differences in metabonomic phenotypes of Lycium ruthenicum and L. barbarum fruits”, J Proteome Res, 17:3223-3236, 2018

9. Q.F. Wan, et al, "Quantitative 13C traces of glucose fate in hepatitis B virus infected hepatocytes", Anal Chem, 89:3293–3299, 2017

10. J. Wang, et al, "Simultaneous quantification of amino metabolites in multiple metabolic pathways using ultra-high performance liquid chromatography with tandem-mass spectrometry", Sci Rep, 7:1435 2017.

11.  Y.L. Hu, et al, “Biological effects of amphiphilic copolymer nanoparticle-encapsulated multi-target chemotherapeutic drugs on MCF-7 human breast cancer cells, Metabolomics, 13:49. 2017

12.  C.X. Liu, et al, "Dynamic metabolic responses of brown planthoppers towards susceptible and resistant rice plants", Plant Biotechnol J, 15:1346–1357, 2017.

13.  H.D. Li, et al, "Decreased glutathione biosynthesis contributes to EGFR T790M-driven erlotinib resistance in non-small cell lung cancer", Cell Discov, 2:16031, 2016.

14. S. Xu, et al, "Tumor growth affects the metabonomic phenotypes of multiple mouse non-involved organs in an A549 lung cancer xenograft model", Sci Rep, 6:28057, 2016.

15. Y. Tian, et al "Tissue metabonomic phenotyping for diagnosis and prognosis of human colorectal cancer", Sci Rep, 6:20790; doi: 10.1038/srep20790, 2016.

16. Z.G. Liu, et al, "Metabolic characteristics of 16HBE and A549 cells exposed to different surface modified gold nanorods", Adv Healthcare Mat, 5:2363–2375, 2016

17. H. Lin, et al, "Correlations of fecal metabonomic and microbiomic changes induced by high-fat diet in the pre-obesity state", Sci Rep, 6:21618, doi: 10.1038/srep21618, 2016.

18. J.F. Wu, et al, "Metabolomics insights into the modulatory effects of long-term low calorie intake in mice", J Proteome Res, 15:2299–2308, 2016.

19. J.F. Wu, et al, "Gender differences of peripheral plasma and liver metabolic profiling in APP/PS1 transgenic AD mice", Neurosci, 332:160-169, 2016.

20. C.X. Liu, et al, "Reprogramming of seed metabolism facilitates pre-harvest sprouting resistance of wheat", Sci Rep, 6:20593; doi: 10.1038/srep20593, 2016.

21. Y. Kumar, et al, "Fusarium oxysporum mediates systems metabolic reprogramming of chickpea roots as revealed by a combination of proteomics and metabolomics", Plant Biotechnol J, 14:1589-1603, 2016.

 

所有论文及引用Full Publication List:https://publons.com/researcher/2776607/huiru-tang/

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