王久存

基本信息

职称:教授
电话:021-31246606
邮箱: jcwang@fudan.edu.cn
地址:复旦大学生命科学学院 A603室

个人简介

实验室网站:https://homo.fudan.edu.cn/

女,博士,博士生导师,生命科学学院人类遗传学与人类学系系主任,皮肤表型组学研究联合实验室共同主任,复旦大学风湿免疫过敏性疾病研究中心副主任,硬皮病临床与研究国际协作网(InSCAR)副理事长。1988及1991年分获复旦大学生物系学士及硕士学位,1999年获日本福井大学生物应用化学专业博士学位。2007-2008年于美国德克萨斯大学休斯顿健康科学中心访问研究。1991-1994年任复旦大学生命科学学院助教、讲师。2000起任复旦大学生命科学学院讲师、副教授、教授。承担国家国际科技合作专项、国家自然科学基金等课题,作为Site-PI(地区PI)承担NIH-U01项目,主持中国地区硬皮病及强直性脊柱炎HLA区域精细结构分析。任Laboratory InvestigationJournal of Scleroderma and Related Disorders等杂志编委。

 

Director of the Department of Anthropology and Human Genetics, School of Life Sciences, Fudan University; Deputy Director of Institute of Rheumatology, Immunology and Allergy, Fudan University; Co-Director of the Joint Laboratory of Skin Phenome. Associate Board Director and Excecutive Committee Member of International Network of Scleroderma Clinical Care and Research (inSCAR); Secretary General of Shanghai Society of Genetics. Undergraduate study at the Dept. of Biology, Fudan University from 1984-1988, B.S. degree in Biology in 1988, and M.S. degree in biology in 1991 from Fudan University. Ph.D in applied biochemistry from Fukui University, Japan in 1999. Research scholar at the University of Texas Health science Center at Houston from 2007-2008. Assistant Professor at Fudan University from 1991-1994. Assistant/Associate Professor/Professor at the School of Life Sciences, Fudan University since 2000. Led one program of International S & T Cooperation, and NSFC Projects. As a Site PI, led the Chinese effort in one NIH-U01 project entitled “Studies of HLA Region Genomics in Systemic Sclerosis and Ankylosing Spondylitis”. Serves as an Editorial Board Member for Laboratory Investigation, Journal of Scleroderma and Related Disorders, and Gout and Hyperuricemia. Published more than 100 papers in peer-reviewed journals in recent 5 years.

 

主要研究方向 (Research Interests) 

 硬皮病、强直性脊柱炎等风湿免疫性疾病的遗传学及分子致病机理研究。Works on the genetics and molecular mechanism of scleroderma and ankylosing spondilitis.

 

获奖情况 (Awards)

复旦大学风湿、免疫、过敏性疾病研究中心2012年度“精英奖” (Elite Award in 2012 of the Institute of Rheumatology, Immunology and Allergy, Fudan University).

 

代表性成果(Recent Representative Publications)

1) Guo S#, Jiang S#, Epperla N, Ma Y, Maadooliat M, Ye Z, Olson B, Wang M, Kitchner T, Joyce J, Strenn R, Mazza J, Meece JK, Wu W, Jin L, Smith JA, Wang J* and Schrodi SJ*. A gene-based recessive diplotype exome scan discovers FGF6, a novel hepcidin-regulating iron metabolism gene. Blood 2019:blood-2018-10-879585

2) Liu J#, Pu W#, Li Y, Ma Y, Zhu Q, Wan W, Yang C, Wang X, Chen X, Zhou X, Reveille JD, Jin L, Zou H*, Wang J*. Genetic association of non-MHC region with ankylosing spondylitis in a Chinese population. Ann Rheum Dis. 2018 Dec 14. pii: annrheumdis-2018-214625.

3) Ding W#, Pu W#, Jiang S, Ma Y, Liu Q, Wu W, Chu H, Zou H, Jin L, Wang J*, Zhou X*. Evaluation of the antifibrotic potency by knocking down SPARC, CCR2 and SMAD3. EBioMedicine. 2018 Dec;38:238-247.

4) Ding W, Pu W, Wang L, Jiang S, Zhou X, Tu W, Yu L, Zhang J, Guo S, Liu Q, Ma Y, Chen S, Wu W, Reveille J, Zou H, Jin L, Wang J*. Genome-wide DNA methylation analysis in systemic sclerosis reveals hypomethylation of interferon-associated genes in CD4+ and CD8+ T cells. J Invest Dermatol. 2018 May;138(5):1069-1077.

5) Chu H, Wu T, Wu W, Tu W, Jiang S, Chen S, Ma Y, Liu Q, Zhou X, Jin L, Wang J*. Involvement of collagen-binding heat shock protein 47 in scleroderma-associated fibrosis. Protein Cell. 2015 Aug;6(8):589-98.

6) Wu J, Liu J, Zhou Y, Ying J, Zou H, Guo S, Wang L, Zhao N, Hu J, Lu D, Jin L, Li Q, Wang JC*. Predictive value of XRCC1 gene polymorphisms on platinum-based chemotherapy in advanced non-small cell lung cancer patients: A systematic review and meta-analysis. Clin Cancer Res. 2012;18(14):3972-3981.

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