王应祥

基本信息

职称:研究员  Professor
电话:021-31246537
邮箱:yx_wang@fudan.edu.cn
地址:复旦大学生命科学学院 E401-1室

 

个人简介

男,博士,研究员,博士生导师。2007年获华南农业大学植物营养学博士学位;2004-2005美国宾州州立大学生物系访问学者;2007-2011年分别在华南农业大学和复旦大学从事博士后研究;2013-2014美国宾州州立大学生物系访问学者;2011-至今 任复旦大学生命科学学院副研究员、研究员。

Ph.D studies in Plant Nutrition at South China Agricultural University (2007); Post-doctoral fellow at South China Agricultural University (2007-2009) and Fudan University (2009-2011); Associate Professor (2011-2015) and Professor (2016-present) at the School of Life Sciences, Fudan University.

 

主要研究方向 (Research Interests)

采用分子遗传学、细胞生物学、基因组学、蛋白质组学和生物信息学等手段, 以模式植物拟南芥和蔬菜为材料,研究:(1)植物生殖发育关键环节减数分裂的遗传和表观遗传调控机制;(2)动植物减数分裂的共性和特性。

Using molecular genetics, cell biology, genomics, proteomics and bioinformatics and other approaches in Arabidopsis and vegetables to study: (1) the molecular mechanisms in regulation of meiosis during plant reproductive development; (2) the conservation and divergence of meiosis between animals and plants.

 

获奖情况 (Awards)

国家杰出青年基金获得者,2019

复旦大学“卓识杰出人才”,2019

上海市青年启明星计划,2013

复旦大学“卓学优秀人才”,2012

 

代表性成果[Selected Publications; total 36; * corresponding author(s)]

(1) Wang J#, Yu CY#, Zhuang SB, Ye JY, Dai H, Wang HK, Huang JY, Cao XF, Ma JB*, Ma H*, Wang YX*.Cell-type-dependent histone demethylase specificity promotes meiotic chromosome condensation in Arabidopsis. Nature Plants, 2020, 10.1038/s41477-020-0697-0.

(2) Wang HK#, Xu WY#, Sun YJ, Lian QC, Wang C, Yu CY, He CP, Wang J, Ma H, Copenhaver GP*, Wang YX*. The cohesin loader SCC2 contains a PHD finger that is required for meiosis in land plants. PLOS Genetics, 2020, doi.org/10.1371/journal.pgen.1008849.

(3) Huang JY#, Wang C#, Li X, Fang XL, Huang N, Wang Y, Ma H, Wang YX*, Copenhaver GP*. Conservation and divergence in the meiocyte sRNAomes of Arabidopsis, soybean and cucumber. Plant Physiology, 2020, 82: 301-317.

(4) Xu RY#, Xu J#,  Wang LD#, Niu BX, Copenhaver GP, Ma H, Zheng BL, Wang YX*. The Arabidopsis anaphase promoting complex/cyclosome subunit 8 is required for male meiosis. New Phytologist, 2019, 224(1):229-24.

(5) Huang JY#, Wang C#, Wang HF, Lu PL, Zheng BL, Ma H, Copenhaver GP, Wang YX*. Meiocyte-specific and AtSPO11-1-dependent small RNAs and their association with meiotic gene expression and recombination. Plant Cell, 2019, 31:1-21.

(6) Wang C#, Huang JY#, Zhang J, Wang HK, Han YP, Copenhaver GP, Ma H, Wang YX*. The Largest Subunit of DNA Polymerase Delta is Important for Normal Formation of Meiotic Type I Crossovers in Arabidopsis. Plant Physiology, 2019, 179: 446-459.

(7) Xue M#, Wang J#, Jiang LG, Wolfe S, Pawlowskic WP*, Wang YX*, He Y* (2018) The number of meiotic double-strand breaks influences crossover distribution in Arabidopsis. Plant Cell, 2018, 30: 2628-2638,

(8) Wang Y*, Copenhaver GP*. Meiotic Recombination: Mixing It Up in Plants. Annual Review Plant Biology. 2018, 69: 577-609

(9) Su H#, Chen ZH#, Huang JY, Lin J, Copenhaver GP, Ma H, Wang YX*. Arabidopsis RAD51, RAD51C and XRCC3 proteins form a complex and facilitate RAD51 localization on chromosomes for meiotic recombination. PLOS Genetics, 2017, e1006827. doi: 10.1371

(10) Wang J, Niu BX, Huang JY, Wang HK, Yang XH, Dong AW, Mackaroff C, Ma H, Wang YX*. Arabidopsis MMD1 Ensures the Progression of Male Meiotic Chromosome Condensation and Directly Regulates the Expression of Condensin Gene CAP-D3. Plant Cell. 2016, 28:1894-1909.

(11) Niu BX#, Wang LD#, Zhang LS, Ren D, Ren R, Copenhaver GP, Ma H*, Wang YX*. The Arabidopsis CDC20.1 Gene is Required for Normal Meiotic Spindle Assembly and Chromosome Segregation. Plant Cell. 2015, 27:1-16.

(12) Huang JY#, Cheng ZH#, Wang C, Hong Y, Su H, Wang H, Copenhaver GP, Ma H*, Wang YX*. Formation of interference-sensitive meiotic crossovers requires sufficient DNA leading strand elongation. PNAS, 2015, 112:12534-9.

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