王永明

基本信息

职称:研究员

电话:021-51630624
邮箱:yonmiwang@gmail.com
地址:复旦大学生命科学学院 C623室

 

个人简介

博士,研究员,博士生导师。1997-2001年就读兰州大学生命科学学院并获得学士学位,2001-2004年就读东北师范大学生命科学学院并获得硕士学位,2005-2010年在德国马克斯-德尔布吕克分子医学中心(MDC)做博士生研究,并获得柏林自由大学博士学位。2010-2013年在斯坦福大学医学院从事博士后研究。2013年至今历任复旦大学生命科学学院青年研究员、研究员。

 

实验室链接:http://heartlab.fudan.edu.cn/

 

主要研究方向 (Research Interests)

1.建立高效的CRISPR/Cas9基因编辑技术;2.运用基因组编辑技术把基因突变引入到人体多潜能干细胞中制作心脏病模型,并通过这些模型研究先天性心脏病的发病机理和筛选治疗药物3.运用CRISPR/Cas9纠正人体的遗传突变,治疗疾病。

 

获奖情况 (Awards)

2015年,入选中组部青年千人计划

 

代表性成果

1. Wang YM*, Pryputniewicz-Dobrinska D*, Nagy EE*, Kaufman CD*, Singh M, Yant S, Wang J, Dalda A, Kay MA, Ivics Z, Izsvak Z. Regulated complex assembly safeguards the fidelity of Sleeping Beauty transposition. Nucleic Acids Research. 2017 Jan; 45(1):311-326 (IF: 8.2).

2. Qi JL*, Dong ZJ*, Shi YW, Wang X, Qin YY, Wang YM, Liu D. NgAgo-based fabp11a gene knockdown causes eye developmental defects in zebrafish. Cell Research. 2016 Dec; 26(12): 1349-1352 (IF: 14.8).

3. He ZH*, Sun S*, Waqas M, Zhang XL, Qian FP, Cheng C, Zhang MS, Zhang SS, Wang YM, Tang ML, Li HW, Chai RJ. Reduced TRMU expression increases the sensitivity of hair-cell-like HEI-OC-1 cells to neomycin damage in vitro. Scientific Reports. 2016 Jul; 13;6: 29621 (IF: 5.2).

4. Wang YM*, Liang P*, Lan F*, Wu HD*, Lisowski L, Gu MX, Hu SJ, Kay MA, Urnov FD, Shinnawi R, Gold J, Gepstein L, Wu JC. Genome editing of isogenic human induced pluripotent stem cells recapitulates long QT phenotype for drug testing. Journal of the American College of Cardiology. 2014 Aug; 64 (5): 451-459 (IF: 14.1).

5. Wang YM*, Wang JC*, Chen JX, Deveraj A, Selbach M, Ivics Z and Izsvak Z. Suicidal autointegration of Sleeping Beauty and piggyback transposons in eukaryotic cells. PlOS Genetics. 2014 Mar; 10(3): e10043103 (IF: 8.5).

6. Liang P*, Lan F*, Lee AS*, Gong TY, Sanchez-Freire V, Wang YM, Nguyen PK, Bers D, Robbins RC, Wu JC. Drug screening using a library of human induced pluripotent stem cell-derived cardiomyocytes reveals disease specific patterns of cardiotoxicity. Circulation. 2013 Apr; 127(16): 1677-91 (IF: 15.2).

7. Hu SJ, Wilson KD, Ghosh Z, Han L, Wang YM, Lan F, Ransohoff KJ, Wu JC. MicroRNA-302 increases reprogramming efficiency via repression of NR2F2. Stem Cells. 2013 Feb; 31(2):259-68 (IF: 7.7).

8. Lan F*, Lee AS*, Liang P*, Sanchez-Freire V, Nguyen PK, Wang L, Han L, Yen M, Wang YM, Sun N, Abilez OJ, Hu SJ, Ebert AD, Navarrete EG, Simmons CS, Wheeler M, Pruitt B, Lewis R, Yamaguchi Y, Ashley EA, Bers DM, Robbins RC, Longaker MT, Wu JC. Abnormal Calcium Handling Properties Underlie Pathogenesis of Familial Hypertrophic Cardiomyopathy in Patient-Specific Induced Pluripotent Stem Cells. Cell Stem Cell. 2013 Jan; 12(1) 101-13. (IF: 25.3).

9. Wang YM Zhang WY, Hu S, Lan F, Lee AS, Huber B, Lisowski L, Liang P, Huang M, de Almeida PE, Won JH, Sun N, Robbins RC, Kay MA, Urnov FD, Wu JC*.Genome editing of human embryonic stem cells and induced pluripotent stem cells with zinc finger nuclease for cellular imaging. Circulation Research. 111(12): 1494-503 (IF: 11.9).

10. Nguyen PK, Lan F, Wang YM, Wu JC. Imaging: Guiding the clinical translation of cardiac stem cell therapy. Circulation Research. 2011;109:962-979 (IF: 9.5).

11. Wang YM, Liska F*, Gosele C, Sedova L, Kren V, Krenova D, Ivics Z, Hubner N, and Izsvak Z. A novel active endogenous retrovirus family contributes to genome variability in rat inbred strains. Genome Research. 2010 Jan; 20(1) 19-27. (IF: 14.4).

 

Copyright © 2014 School of Life Sciences Fudan University All Rights Reserved
联系地址:上海市淞沪路2005号