吴家雪

基本信息

职称:研究员
电话:021-31246554
邮箱:jiaxue@fudan.edu.cn
地址:复旦大学生命科学学院 A507室

 

个人简介

教育和工作经历
2006年获复旦大学遗传学博士学位;
2007-2011年在美国密歇根大学医学院从事博士后研究;
2012年任复旦大学生命科学学院研究员,博士生导师。

 

主要研究方向 (Research Interests)

以肿瘤细胞、模式动物和临床样本为模型,研究DNA损伤修复,信号转导和翻译后修饰(磷酸化和腺苷二磷酸核糖化)等在肿瘤(肝癌、肺癌)发生发展和复发转移中的功能及分子机制,为肿瘤诊疗提供重要生物学标志物和分子靶标。

 

获奖情况 (Awards)

 

代表性成果

1. Shao C, Qiu Y, Liu J, Feng H, Shen S, Saiyin H, Yu W, Wei Y, Yu L, Su W, Wu J. PARP12 (ARTD12) suppresses hepatocellular carcinoma metastasis through interacting with FHL2 and regulating its stability. Cell Death Dis. 2018 Aug 28;9(9):856.

2. Zhao Y, Hu X, Wei L, Song D, Wang J, You L, Saiyin H, Li Z, Yu W, Yu L, Ding J, Wu J.PARP10 suppresses tumor metastasis through regulation of Aurora A activity. Oncogene. 2018 May;37(22):2921-2935

3. Hu X, Zhao Y, Wei L, Zhu B, Song D, Wang J, Yu L, Wu J. CCDC178 promotes hepatocellular carcinoma metastasis through modulation of anoikis. Oncogene. 2017 Jul 13;36(28):4047-4059

4. Wang J, Zhu C, Xia R, Yu W, Dang Y, Fei Y, Yu L, Wu J. Epigallocatechin-3-gallate enhances ER stress-induced cancer cell apoptosis by directly targeting PARP16 activity. Cell Death Discovery (2017) 3, e17034;

5. Liu C*, Wu J*, Paudyal SC, You Z, Yu X. CHFR is important for the first wave of ubiquitination at DNA damage sites. Nucleic Acids Res. 2013 Feb 1;41 (3):1698-710. (*Co-First Author)

6. Wu J*, Liu C*, Chen J, Yu X. RAP80 protein is important for genomic stability and is required for stabilizing BRCA1-A complex at DNA damage sites in vivo. J Biol Chem. 2012 Jun 29;287(27):22919-26. (*Co-First Author)

7. Wu J, Chen Y Lu LY, Wu Y, Paulsen MT, Ljungman M, Ferguson DO, Yu X. Chfr and RNF8 synergistically regulate ATM activation. Nat Struct Mol Biol. 2011 Jun 26;18(7):761-8.

8. Wu J, Lu LY, Yu X. The role of BRCA1 in DNA damage response. Protein Cell. 2010 Feb;1(2):117-23. Review.

9. Wu J, Huen MS, Lu LY, Ye L, Dou Y, Ljungman M, Chen J, Yu X. Histone ubiquitination associates with BRCA1-dependent DNA damage response. Mol Cell Biol. 2009 Feb;29(3):849-60. 

10. Zhang F*, Ma J*, Wu J*, Ye L, Cai H, Xia B, Yu X. PALB2 links BRCA1 and BRCA2 in the DNA-damage response. Curr Biol. 2009 Mar 24;19(6):524-9.(*Co-First Author)

 

 

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