张锋

基本信息

职称:教授、博士生导师

电话:021-51630423
邮箱:feng.fudan@gmail.com
地址:复旦大学生命科学学院 E601-6室

 

个人简介

实验室网址:http://www.gdg-fudan.org/
张锋,复旦大学附属妇产科医院、生殖与发育研究院教授、博士生导师。上海市女性生殖内分泌相关疾病重点实验室副主任。复旦大学生命科学学院、遗传工程国家重点实验室双聘PI。获得国家杰出青年科学基金、国家万人计划青年拔尖人才、教育部青年长江学者等人才计划支持。任中国遗传学会青年委员会副主任委员、中国优生科学协会基因诊断学分会常务委员。

 

主要研究方向 (Research Interests)

张锋教授课题组一直致力于人类基因组拷贝数变异(Copy Number Variation, CNV)及其致出生缺陷、不孕不育等疾病的基础和转化研究。已在New England Journal of Medicine, Nature Genetics, AJHG等高影响力期刊上发表SCI论文和综述72篇,累计被引用2942次。

 

获奖情况 (Awards)

• 药明康德生命化学杰出成就奖,2015
• 全国妇幼健康科学技术奖自然科学一等奖(第三完成人),2015
• 盖茨基金会“大挑战2015·青年科学家”,2015
• 中国出生缺陷干预救助基金会“青年学者奖”,2014
• 华夏医学科技奖三等奖(第四完成人),2013

 

代表性成果

1. Wu N*, Ming X*, Xiao J*, Wu Z*, Chen X*, Shinawi M, Shen Y, Yu G, Liu J, Xie H, Gucev ZS, Liu S, Yang N, Al-Kateb H, Chen J, Zhang J, Hauser N, Zhang T, Tasic V, Liu P, Su X, Pan X, Liu C, Wang L, Shen J, Shen J, Chen Y, Zhang T, Zhang J, Choy KW, Wang J, Wang Q, Li S, Zhou W, Guo J, Wang Y, Zhang C, Zhao H, An Y, Zhao Y, Wang J, Liu Z, Zuo Y, Tian Y, Weng X, Sutton VR, Wang H, Ming Y, Kulkarni S, Zhong TP, Giampietro PF, Dunwoodie SL, Cheung SW, Zhang X, Jin L, Lupski JR, Qiu G#, Zhang F# (2015) TBX6 Null Variants and a Common Hypomorphic Allele in Congenital Scoliosis. New England Journal of Medicine 372:341-350.

2.Chen L, Zhou W, Zhang C, Lupski JR, Jin L, Zhang F# (2015) CNV instability associated with DNA replication dynamics: evidence for replicative mechanisms in CNV mutagenesis. Human Molecular Genetics 24(6):1574-1583.

3.Sun Z, Liu P, Jia X, Withers MA, Jin L, Lupski JR, Zhang F# (2013) Replicative mechanisms of CNV formation preferentially occur as intrachromosomal events: evidence from Potocki-Lupski duplication syndrome. Human Molecular Genetics 22(4):749-756.

4.Zhang F, Gu W, Hurles ME, Lupski JR (2009) Copy number variation in human health, disease, and evolution. Annual Review of Genomics and Human Genetics 10:451-481.

5.Zhang F, Khajavi M, Connolly AM, Towne CF, Batish SD, Lupski JR (2009) The DNA replication FoSTeS/MMBIR mechanism can generate human genomic, genic, and exonic complex rearrangements. Nature Genetics 41(7):849-853.

 

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