张雪莲

基本信息

职称:副教授
电话:021-516
30587
邮箱:xuelianzhang@fudan.edu.cn
地址:复旦大学生命科学学院 C501室

 

个人简介

2003年于南京农业大学动物医学院获博士学位。2003-2005于复旦大学生命科学学院遗传研究所进行博士后工作。2005.7–至今,复旦大学生命科学学院,讲师,副教授。2009 - 2010 约翰霍普金斯大学公共卫生学院,访问学者。

 

主要研究方向 (Research Interests)

主要利用微生物学、分子生物学、细胞生物学、遗传学等方法开展结核分枝杆菌感染致病的基础研究。主要包括(1)翻译后修饰调控结核杆菌感染致病的分子机制; (2)新型抗结核药物发现及其分子作用机制。目前主持及参加在研项目包括国家自然科学基金面上项目(81673482)、上海市科技支撑项目(15431900200)及国家重点研发计划(2016YFA0500600)等。

 

获奖情况 (Awards)

 

 

代表性成果

1. Jing Bi#, Yihong Wang#, Heguo Yu, Xiaoyan Qian, Honghai Wang, Jun Liu*, Xuelian Zhang* Modulation of Central Carbon Metabolism by Acetylation of Isocitrate Lyase in Mycobacterium tuberculosis, Scientific Reports,2017, | 7:44826 | DOI: 10.1038/srep44826

2. Juanjuan Yang(#),Yindi Liu,Jing Bi,Qixu Cai,Xinli Liao,Wenqian Li,Chenyun Guo,Qian Zhang,Tianwei Lin,Yufen Zhao,Honghai Wang,Jun Liu*,Xuelian Zhang*,Donghai Lin* Structural basis for targeting the ribosomal protein S1 of Mycobacterium tuberculosis by pyrazinamide,Molecular Microbiology,2015,95(5):791-803

3. Wanliang Shi,Xuelian Zhang,Xin Jiang,Haiming Yuan,Jong Seok Lee,Clifton E. Barry 3rd,Ying Zhang* Pyrazinamide Inhibits Trans-Translation inMycobacterium tuberculosis,Science,2011,333:1630-1632

4. Chunmei Zhou,Bijie Hu*,Xuelian Zhang*,Shenglei Huang,Yuzhang Shan,Xiangru Ye,The value of matrix-assisted laser desorption/ionization time-of-flight mass spectrometry in identifying clinically relevant bacteria: a comparison with automated microbiology system Journal of Thoracic Disease,2014,6(5):545-552

5. Lina Shi,Haiping Zhang,Yu Qiu,Qian Wang,Xueji Wu,Honghai Wang,Xuelian Zhang*,Donghai Lin* Biochemical characterization and ligand-binding properties of trehalose-6-phosphate phosphatase from Mycobacterium tuberculosis,Acta Biochimica et Biophysica Sinica,2013,45(10):837-844

6. Rusong Luo,Tuomo Laitinen,Liyan Teng,Tapio Nevalainen,Maija Lahtela-Kakkonen,,Baofu Zheng,Honghai Wang*,Antti Poso*,Xuelian Zhang*,Synthesis and Biological Evaluation of Arylthiourea Derivatives with Antitubercular Activity,Letters in Drug Design & Discovery,2013,10:640-650

 

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