郑煜芳

基本信息

职称:研究员
电话:
13818081031 (C)
邮箱:zhengyf@fudan.edu.cn
地址:上海市邯郸路220号,复旦大学逸夫科技楼605-1,邮编200438

 

个人简介

1976年5月出生,1993年进入清华大学生物科学与技术系,1997年获学士学位,1999年获理学硕士学位。1999年8月赴美国康奈尔大学医学院生理、生物物理和分子医学系,于2004年获博士学位。同年获美国耶鲁大学的Endowed Postdoctoral Fellowship,从事博士后研究。2007年起获聘为复旦大学副教授,硕导。2013年8月兼职复旦大学发育生物学研究所PI。2016年3月起任复旦大学附属妇产科医院生殖发育研究院副研究员PI,2017年12月起任研究员PI。曾获得上海市浦江人才计划,复旦大学卓学人才计划等奖项。承担多项国家自然基金委项目和上海市科委项目;并作为课题骨干参与基金委重点项目,国家重点研发计划,973,863等项目。入职以来共发表论文50篇,其中在Cell Research, Cell Death & Differentiation, Clinical Science等杂志上发表第一作者和通讯作者论文21篇。

 

主要研究方向 (Research Interests)

实验室针对胚胎发育不同时期和不同过程,研究发育过程中的遗传发育机制和发育异常导致的重大疾病的分子机制。

 

获奖情况 (Awards)

2015年                       复旦大学 三八红旗手

2012-2014年             复旦大学 卓学人才计划

2010,2012-2014年    复星医药奖教金“个人奖”四次

2008年                      上海市浦江人才计划,2010年获评优秀

 

承担的科研项目 (Projects)

1. 国家重点研发计划(2018YFA0800300,2019-2024年)“组织器官发育中重要新型代谢物鉴定及其功能” 课题骨干,总额2005万,个人90万

2. 国家自然科学基金委面上项目(81870894,2019.1-2022.12)“叶酸不应答性神经管畸形发生机制及预防新策略” 课题负责人,56万

3. 上海市教委科研创新计划项目(2019-01-07-00-07-E00041, 2019.1-2023.12)“肥胖动物模型的遗传代谢和神经调控研究”课题骨干,总额300万,个人75万

4. 国家自然科学基金委应急项目(81741048,2018.1-2018.12)“神经管畸形新候选基因和突变致病性筛查” 课题负责人,20万

5. 上海市科技科委重大项目(17JC1400902, 2017.9-2020.8) “基于“人造精子”技术的复杂疾病建模研究” 课题骨干

6. 上海市科技创新基础研究重点项目(14JC1401000, 2014.8-2017.7)“利用PB转座子小鼠库中涉及新基因的重大出生缺陷表型筛查研究” 课题负责人,60万

7. 国家重大科学研究计划项目“代谢物失衡和信号通路异常致出生缺陷的分子机理”课题四(2013CB945404,2013.1-2017.8),课题骨干,总额2600万,个人130万

8. 863计划项目“代谢物组与非编码RNA的系统识别与鉴定关键技术研发”课题四“基因突变小鼠库的非编码RNA功能鉴定技术与应用”(2014AA021104,2014.1-2016.12)课题骨干,总额454万,个人104万

9. 国家自然科学基金重点项目(81430005,2015.1-2019.12)“赖氨酸同型半胱氨酸修饰致先天性心脏病的作用及机理”,课题骨干,340万

10. 国家自然科学基金青年基金(30800322,2009.1-2011.12)课题负责人,24万

上海市浦江人才计划(08PJ1401300,2008.8-2010.7)课题负责人,20万

11. 国家教育部高等学校博士学科专项基金新教师基金(200802461050,2010.1-2011.12)课题负责人,3.6万

12. 国家教育部留学回国人员启动基金(2008.1-2010.12)课题负责人,3万

 

代表性成果(Papers)

 

1. Wang Y#, Zheng Y# ,*, Yang S, Yang Z, Zhang L, He Y, Gong X, Liu D, Finnell R.H., Qiu Z, Du Y*, Wang H*. MicroRNA-197 controls ADAM10 expression to mediate MeCP2’s role in the differentiation of neuronal progenitors. Cell Death & Differ 2019 Oct;26(10):1863-1879.

2. Xie Y, Ma A, Wang B, Peng R, Jing Y, Wang D, Finnell RH., Qiao B, Wang Y*, Wang H*, Zheng Y* . Rare mutations of ADAM17 from TOFs induce hypertrophy in human embryonic stem cell-derived cardiomyocytes via HB-EGF signaling. Clin Sci (Lond). 2019 Jan 22;133(2):225-238.

3. Chen Z#, Lei Y#, Zheng Y#, Aguiar-Pulido V, Ross M.E., Peng R, Jin L, Zhang T*, Finnell R.H.,*, Wang H*. Threshold for neural tube defect risk by accumulated singleton loss-of-function variants. Cell Res. 2018 Oct;28(10):1039-1041.

4. Wang B, Zhang Y, Dong H, Gong S, Wei B, Luo M, Wang H, Wu X, Liu W, Xu X*, Zheng Y*, Miao Sun*. Loss of Tctn3 causes neuronal apoptosis and neural tube defects in mice. Cell Death Dis. 2018 May 3;9(5):520.

5. Gao X, Finnell R, Wang H, Zheng Y* . Network correlation analysis revealed potential new mechanisms for neural tube defects beyond folic acid. Birth Defects Res. 2018 Jul 17;110(12):982-993.

6. Kim J#, Lei Y#, Guo J, Kim S, Wlodarczyk B, Robert M. Cabrera RM, Lin Y, Nilsson T, Zhang T, Ren A, Wang L, Yuan Z, Zheng Y, Wang H*, Finnell RH.* Formate Rescues Neural Tube Defects Caused by Mutations in Slc25a32. PNAS, 2018 May 1;115(18):4690-4695.

7. Chen Z, Lei Y, Cao X, Zheng Y, Wang F, Bao Y, Peng R, Finnell RH*, Zhang T*, Wang H*. Genetic analysis of Wnt/PCP genes in neural tube defects. BMC Med Genomics. 2018 Apr 4; 11(1): 38.

8. Shi Z, Yang X, Li B, Chen S, Yang L, Chen L, Zhang T, Wang H, Zheng Y*. Novel mutation of LRP6 identified in Chinese Han population links canonical WNT signaling to neural tube defects. Birth Defects Res. 2018 Jan 15;110(1):63-71.

9. Wang B#, Zheng Y#, Shi H, Du X, Zhang Y, Wei B, Luo M, Wang H, Wu X, Hua X, Sun M*, Xu X*. Zfp462 deficiency causes anxiety-like behaviors with excessive self-grooming in mice. Genes Brain Behav. 2017 Feb;16(2):296-307.

10. Qiao X#, Liu Y#, Li P, Chen Z, Li H, Yang X, Finnell RH, Yang Z, Zhang T, Qiao B, Zheng Y*, Wang H*. Genetic analysis of rare coding mutations of CELSR1-3 in congenital heart and neural tube defects in Chinese people. Clin Sci (Lond). 2016 Dec 1. 130(24): 2329-40

11. Liu B, Ma A, Zhang F, Wang Y, Li Z, Li Q, Xu Z, Zheng Y*. MAZ mediates the cross-talk between CT-1 and NOTCH1 signaling during gliogenesis. Sci Rep, 2016 Feb 12;6:21534.

12. Li P, Li H, Zheng Y, Qiao B, Duan W, Huang L, Liu W, Wang H*. Variants in the Regulatory Region of WNT5A Reduced Risk of Cardiac Conotruncal Malformations in the Chinese Population. Sci Rep, 2015 Aug 17;5:13120.

13. Li Q, Zhang Z, Li Z, Zhou M, Liu B, Pan L, Ma Z, Zheng Y*. ADAM17 is critical for multipolar exit and radial migration of neuronal intermediate progenitor cells in mice cerebral cortex. PLoS ONE 2013 June 3; 8(6): e65703.

14. Ma Z, Li Q, Zhang Z, Zheng Y*. A Disintegrin and Metalloprotease 10 in neuronal maturation and gliogenesis during cortex development. Neural Regen Res. 2013 8(1):24-30

15. Peng C, Ye J, Yan S, Kong S, Shen Y, Li C, Li Q, Zheng Y, Deng K, Xu T, Tao W. Ablation of vacuole protein sorting 18 (vps18) gene leads to neurodegeneration and impaired neuronal migration by disrupting multiple vesicle transport pathways to lysosomes. J Biol Chem. 2012 Sep 21; 287(39):32861-73.

16. Li J, Liu B, Gao X, Ma Z, CaoSong T, Mei Y, Zheng Y*. Overexpression of Sigma-1 receptor inhibits ADAM10 and ADAM17 mediated shedding in vitro. Protein Cell 2012 Feb; 3(2): 153-9.

17. Zhang WB, Cheng MJ, Huang YT, Jiang W, Cong Q, Zheng YF*, Xu CJ*. A study in vitro on differentiation of bone marrow mesenchymal stem cells into endometrial epithelial cells in mice. Eur J Obstet Gynecol Reprod Biol. 2012 Feb; 160(2): 185-90.

18. Jin K, Xue C, Qian J, Zhu Y, Wu X, Yang Z, Yonezawa T, M. James C. Crabbe, Cao Y, Hasegawa M, Zhong Y*, Zheng Y*. Why does the giant panda eat bamboo? A comparative analysis of appetite-reward-related genes among mammals. PLoS ONE 2011; 6(7):e22602.

19. Zhang LP#, Zheng Y#, Li D, Zhong Y. Self-organizing Map of Gene Regulatory Networks for Cell Phenotypes during Reprogramming. Comput Biol Chem. 2011 Aug 10; 35(4):211-7.

20. Zhang X, Chen J, Zheng Y, Gao X, Kang Y, Zhang J, Cheng M, Sun H, Xu C* Follicle stimulating hormone peptide can facilitate paclitaxel nanoparticles target to ovarian carcinoma in vivo. Cancer Res 2009 Aug 15; 69(16):6506-14.

21. Kang Y, Zhang X, Jiang W, Wu C, Chen C, Gu J, Zheng Y*, and Xu C* The piggyBac transposon is an integrating non-viral gene transfer vector that enhances the efficiency of GDEPT. Cell Biol Int, 2009 Apr; 33: 509-515

22. Ly A, Nikolaev A, Suresh G, Zheng Y, Tessier-Lavigne M, Stein E. DSCAM is a netrin receptor that collaborates with DCC in mediating turning responses to netrin-1. Cell, 2008 Jun 27; 133: 1241-1254

23. Zheng Y, Peschon J, Saftig P, Hartmann D, Blobel CP. Evaluation of the contribution of different ADAMs to tumor necrosis factor alpha (TNFalpha) shedding and of the function of the TNFalpha ectodomain in ensuring selective stimulated shedding by the TNFalpha convertase (TACE/ADAM17). J. Biol Chem. 2004 Oct 8; 279(41): 42898-906

24. Zheng Y, Schlondorff J, Blobel CP. Evidence for regulation of the tumor necrosis factor alpha-convertase (TACE) by protein-tyrosine phosphatase PTPH1. J Biol Chem. 2002 Nov 8; 277(45): 42463-70

 

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