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地址:复旦大学生命科学学院 G607室



男,1969年12月生,博士,教授,博士生导师。1991年本科毕业于浙江大学化学系,获学士学位 (化学专业)。分别于1994、1998年在浙大获硕士、博士学位 (物理化学专业)。1999-2000年在柏林洪堡大学生物系分子生物物理专业从事博士后研究。2001-2003年间又两次回到该系及到台湾中山大学化学系继续研究工作。2004年12月进入复旦大学生命科学学院工作,2005年起历任副教授、教授。

B. Sc. degree in Chemistry from Zhejiang University in 1991, M. Sc. and Ph. D. degrees in Physical Chemistry from Zhejiang University in 1994 and 1998, respectively. Post-doctoral study in Molecular Biophysics at Department of Biology, Humboldt University of Berlin from 1999 to 2000. Short-term research at Humboldt University and National Sun Yat-sen University during 2001-2003. Fudan University since December 2004, and as associate professor /full professor from 2005.


主要研究方向 (Research Interests)

Genetic engineering: structural biochemistry of gene editing systems and frontier technologies; Medical genetics: cancer drug design (small molecules, protein or nucleic-acid therapeutics); Structural bioinformatics: theory and simulation of biomolecular structures and interactions.


获奖情况 (Awards)

第五届中国技术市场协会金桥奖(2011年度;第二完成人),上海市科技发明奖二等奖 (2012年度;第三完成人) , 教育部技术发明奖二等奖 (2012年度;第三完成人)。


代表性论文与成果 [Representative Papers and Achievements; *Corresponding author(s)]

1. C. Huai, G. Li, R. Yao, Y. Zhang, M. Cao, L. Kong, C. Jia, H. Yuan, H. Chen, D. Lu*, Q. Huang*. (2017). Structural insights into DNA cleavage activation of CRISPR-Cas9 system. Nature Communications. 8:1375.

2. H. Yuan, J. Wu, X. Wang, J. Chen, Y. Zhong, Q. Huang*, P. Nan*. (2017). Computational identification of amino-acid mutations that further improve the activity of a chalcone-flavonone isomerase from Glycine max. Frontiers in Plant Science. 8:248.

3. Q. Huang, L. Yu, A. J. Levine, R. Nussinov, B. Ma. (2014). Dipeptide analysis of p53 mutations and evolution of p53 family proteins. Biochimica et Biophysica Acta-Proteins and Proteomics. 1844:198-206.

4. J. Zhu, Q. Yang, D. Dai, Q. Huang*. (2013). X-ray crystal structure of phosphodiesterase 2 in complex with a highly selective, nanomolar inhibitor reveals a binding-induced pocket important for selectivity. Journal of the American Chemical Society. 135: 11708-11711.

5. M. Xu, L. Yu, B. Wan, L. Yu, Q. Huang*. (2011). Predicting inactive conformations of protein kinases using active structures: conformational selection of type-II inhibitors. PLoS One. 6:e22644.

6. C. You#, Q. Huang#, H. Xue, Y. Xu, H. Lu. (2010). Hydrophobic interaction between two cysteines in interior hydrophobic region of protein improves thermostability of a family 11 xylanase from Neocallimastix patriciarum. Biotechnology and Bioengineering. 105: 861-870. (# contributed equally)

7. H. Shen, F. Xu, H. Hu, F. Wang, Q. Wu, Q. Huang*, H. Wang*. (2008). Coevolving residues of (beta/alpha)8-barrel proteins play roles in stabilizing active site architecture and coordinating protein dynamics. Journal of Structural Biology. 164: 281-292.

8. Q. Huang, C.- L. Chen, A. Herrmann. (2004). Bilayer conformation of fusion peptide of influenza virus hemagglutinin: a molecular dynamics simulation study. Biophysical Journal. 87:14-22.

9. Q. Huang, S. Ding, C. Y. Hua, H. C. Yang, C. L. Chen. (2004). A computer simulation study of water drying at the interface of protein chains. Journal of Chemical Physics. 121:1969-1977.

10. Q. Huang, R. Opitz, E.-W. Knapp, A. Herrmann. (2002). Protonation and stability of the globular domain of influenza virus hemagglutinin. Biophysical Journal. 82:1050-1058.

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