黄强

基本信息

职称:教授
电话:021-
31246589
邮箱:huangqiang@fudan.edu.cn
地址:复旦大学生命科学学院 G607室

 

个人简介

男,博士,教授,博士生导师。1991年本科毕业于浙江大学化学系,获学士学位(化学专业)。分别于19941998年在浙大获硕士、博士学位(物理化学专业)1999-2000年在柏林洪堡大学生物系分子生物物理专业从事博士后研究。2001-2003年间又两次回到该系及到台湾中山大学化学系继续研究工作。200412月进入复旦大学生命科学学院工作,2005年起历任副教授、教授。

B. Sc. degree in Chemistry from Zhejiang University in 1991, M. Sc. and Ph. D. degrees in Physical Chemistry from Zhejiang University in 1994 and 1998, respectively. Post-doctoral study in Molecular Biophysics at Department of Biology, Humboldt University of Berlin from 1999 to 2000. Short-term research at Humboldt University and National Sun Yat-sen University during 2001-2003. Fudan University since December 2004, and as associate professor /full professor from 2005.

 

主要研究方向 (Research Interests)

遗传工程学:蛋白质和核酸药物分子工程;基因编辑系统的结构机理和技术。结构生物信息学:生物大分子结构与相互作用的理论和模拟;人工智能生物技术。

Genetic engineering: Molecular engineering of protein and nucleic-acid therapeutics; Structural mechanisms and technologies of gene editing systems. Structural bioinformatics: Theory and simulation of biomacromolecular structures and interactions; Artificial intelligence in biotechnology.

 

获奖情况 (Awards)

第五届中国技术市场协会金桥奖(2011年度;第二完成人),上海市科技发明奖二等奖 (2012年度;第三完成人) , 教育部技术发明奖二等奖 (2012年度;第三完成人)

 

代表性论文与成果 [Representative Papers and Achievements; *Corresponding author(s)]

1. H. Zhu#; W. Du#, M. Song; Q. Liu, A. Herrmann, Q. Huang*. Spontaneous binding of potential COVID-19 drugs (Camostat and Nafamostat) to human serine protease TMPRSS2, Computational and Structural Biotechnology Journal. 19:467-476 (2021). (#Co-first authors)

2. R. Yao, J. Qian, Q. Huang*. Deep-learning with synthetic data enables automated picking of cryo-EM particle images of biological macromolecules. Bioinformatics. 36:1252-1259 (2020).

3. M. Song#, G. Li#; Q. Zhang#, J. Liu*, Q. Huang*. De novo post-SELEX optimization of a G-quadruplex DNA aptamer binding to marine toxin gonyautoxin 1/4, Computational and Structural Biotechnology Journal. 18:3425-3433 (2020). (#Co-first authors)

4. Q. Liu, A. Herrmann, Q. Huang*. Surface binding energy landscapes affect phosphodiesterase isoform-specific inhibitor selectivity. Computational and Structural Biotechnology Journal. 17:101-109 (2019).

5. C. Huai, G. Li, R. Yao, Y. Zhang, M. Cao, L. Kong, C. Jia, H. Yuan, H. Chen, D. Lu*, Q. Huang*. Structural insights into DNA cleavage activation of CRISPR-Cas9 system. Nature Communications. 8:1375 (2017).

6. J. Zhu, Q. Yang, D. Dai, Q. Huang*. X-ray crystal structure of phosphodiesterase 2 in complex with a highly selective, nanomolar inhibitor reveals a binding-induced pocket important for selectivity. Journal of the American Chemical Society. 135: 11708-11711 (2013).

7. Q. Huang*, A. Herrmann. Calculating pH-dependent free energy of proteins by using Monte Carlo protonation probabilities of ionizable residues. Protein & Cell. 3:230-238(2012).

8. C. You#, Q. Huang#, H. Xue, Y. Xu, H. Lu. Hydrophobic interaction between two cysteines in interior hydrophobic region of protein improves thermostability of a family 11 xylanase from Neocallimastix patriciarum. Biotechnology and Bioengineering. 105: 861-870 (2010). (#Co-first authors)

9. Q. Huang, C.- L. Chen, A. Herrmann. Bilayer conformation of fusion peptide of influenza virus hemagglutinin: a molecular dynamics simulation study. Biophysical Journal. 87:14-22 (2004).

10. Q. Huang, R. Opitz, E.-W. Knapp, A. Herrmann. Protonation and stability of the globular domain of influenza virus hemagglutinin. Biophysical Journal. 82:1050-1058 (2002).

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