徐颖

基本信息

职称:副教授
电话:021-31246
587
邮箱:yingxu2520@fudan.edu.cn
地址:复旦大学生命科学学院C501

 

个人简介

女,1979年出生,博士,副教授。2002-2007年就读于复旦大学生命科学学院,获得理学博士学位。2007-2009年在复旦大学医学院从事博士后研究。2009年-至今在复旦大学生命科学学院任讲师、副教授。

 

主要研究方向 (Research Interests)

主要从事结核分枝杆菌感染与免疫机制的研究。利用分子生物学、细胞生物学、免疫学等技术手段, 研究结核分枝杆菌感染过程中与宿主的相互作用;研究新型抗结核病疫苗及其免疫机制。

 

 获奖情况 (Awards)

结核杆菌耐药性分析及结核病防控策略基础研究 获上海市科技进步三等奖(2015)

 

 代表性成果

1.Su H, Zhang Z, Liu Z, Peng B, Kong C, Wang H, Zhang Z, Xu Y*. Mycobacterium tuberculosis PPE60 antigen drives Th1/Th17 responses via Toll-like receptor 2-dependent maturation of dendritic cells. J Biol Chem. 2018. 293(26):10287-10302.

2. Liulin Luo, Lin Zhu, Jun Yue, Jianping Liu, Guoyuan Liu, Xuelian Zhang, Honghai Wang,and Ying Xu*. Antigens Rv0310c and Rv1255c are promising novel biomarkers for the diagnosis of Mycobacterium tuberculosis infection. Emerging Microbes & Infections 2017, 6, e64.

3. Haibo Su, Shengling Zhu, Lin Zhu, Cong Kong, Qi Huang, Zhi Zhang, Honghai Wang and Ying Xu*. Mycobacterium tuberculosis Latent Antigen Rv2029c from the Multistage DNA Vaccine A39 Drives TH1 Responses via TLR-mediated Macrophage Activation. Frontiers in Microbiology 2017. 8,2266.

4.Su H, Zhu S, Zhu L, Huang W, Wang H, Zhang Z, Xu Y*. Recombinant Lipoprotein Rv1016c Derived from Mycobacterium tuberculosis Is a TLR-2 Ligand that Induces Macrophages Apoptosis and Inhibits MHC II Antigen Processing. Front Cell Infect Microbiol.2016. 18;6:147.

5. Haibo Su, Cong Kong, Lin Zhu, Qi Huang, Liulin Luo, Honghai Wang and Ying Xu*. PPE26 induces TLR2-dependent activation of macrophages and drives Th1-type T-cell immunity by triggering the cross-talk of multiple pathways involved in the host response.Oncotarget.2015. 6(36):38517-37.

6. Li G, Liu G, Song N, Kong C, Huang Q, Su H, Bi A, Luo L, Zhu L, Xu Y*, Wang H.. A novel recombinant BCG-expressing pro-apoptotic protein BAX enhances Th1 protective immune responses in mice. Mol Immunol. 2015. 66(2):346-356.

7. Xu Y, Yang E, Huang Q, Ni W, Kong C, Liu G, Li G, Su H, Wang H. .PPE57 induces activation of macrophages and drives Th1-type immune responses through TLR2. J Mol Med (Berl). 2015. Jan 15.

8. Xu Y, Yang E, Wang J, Li R, Li G, Liu G, Song N, Huang Q, Kong C, Wang H.  Prime-boost bacillus Calmette-Guérin vaccination with lentivirus-vectored and DNA-based vaccines expressing antigens Ag85B and Rv3425 improves protective efficacy against Mycobacterium tuberculosis in mice. Immunology.2014. 143(2):277-86.

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