赵健元

基本信息

职称:研究员
电话:021-
31246422
邮箱:zhaojy@fudan.edu.cn
地址:复旦大学生命科学学院C321

个人简介

男,1980年出生,博士,研究员,博士生导师。1999-2006年就读安徽大学生命科学学院,2003、2006分别获得生物技术专业学士学位和生化分子生物学专业硕士学位,2008-2011年就读复旦大学遗传学专业并获博士学位,2011-2013在美国约翰霍普金斯大学从事博士后研究,2013年9月作为人才引进回复旦大学工作,先后被聘为青年副研究员、副研究员、研究员。

Bachelor degree in Biology technology in 2003, and Master degree in Biochemistry and Molecular Biology in 2006 from Anhui University. Ph.D. in Genetics from the Fudan University in 2011. Post-doctoral fellow at Johns Hopkins University from 2011 to 2013. Then work at Fudan University since 2013.

 

主要研究方向 (Research Interests)

从遗传和代谢的角度研究人类重大出生缺陷(先天性心脏病、神经管畸形)和肿瘤的发病机制,发展新型的干预策略。目前主持863青年科学家专题和多项国家自然基金面上项目,作为骨干参与基金委创新群体基金和国家973项目。

Using molecular genetics, biochemistry, metabonomics approaches to study the genetic and metabolic basis of human birth defects and cancers.

 

获奖情况 (Awards)

国家优秀青年基金(2017)、教育部自然科学一等奖(2015,排名第三)、国家妇幼健康科学技术一等奖(2015,排名第四)、上海市优秀博士论文(2014)、复星奖教金特等奖(2018)、罗氏诊断研究奖(2013)。

 

代表性论文和专著 [Selected Publications; total 20]

1.  Wang D#, Wang F#, Shi KH#, Tao H, Li Y, Zhao R, Lu H, Duan W, Qiao B, Zhao SM*, Wang H*, Zhao JY*. Lower Circulating Folate Induced by a Fidgetin Intronic Variant Is Associated With Reduced Congenital Heart Disease Susceptibility. Circulation. 2017 May 2; 135(18): 1733-1748.

2.  Xu S#, Liu CX#, Xu W, Huang L, Zhao JY*, Zhao SM*. Butyrate induces apoptosis by activating PDC and inhibiting complex I through SIRT3 inactivation. Signal Transduction & Target Therapy. 2017 Feb 10; 2, e16035. doi: 10.1038/sigtrans.2016.35.

3.  Zhao JY#, Liang L#, Gu X#, Li Z, Wu S, Sun L, Atianjoh FE, Feng J, Mo K, Jia S, Lutz BM, Bekker A, Nestler EJ, Tao YX*. DNA methyltransferase DNMT3a contributes to neuropathic pain by repressing Kcna2 in primary afferent neurons. Nature Communications. 2017 Mar 8; 8:14712.

4.  Zhao JY#, Qiao B#, Duan WY#, Gong XH, Peng QQ, Jiang SS, Lu CQ, Chen YJ, Shen HB, Huang GY*, Jin L*, Wang HY*. Genetic variants reducing MTR gene expression increase the risk of congenital heart disease in Han Chinese populations. European Heart Journal. 2014 Mar; 35(11): 733-42.

5.  Xu JT#, Zhao JY#, Zhao X#, Ligons D, Tiwari V, Atianjoh FE, Lee CY, Liang L, Zang W, Njoku D, Raja SN, Yaster M, Tao YX. Opioid receptor-triggered spinal mTORC1 activation contributes to morphine tolerance and hyperalgesia. The Journal of Clinical Investigation. 2014 Feb; 124(2): 592-603.

6.  Zhao X#, Tang Z#, Zhang H#, Atianjoh FE#, Zhao JY#, Liang L, Wang W, Guan X, Kao SC, Tiwari V, Gao YJ, Hoffman PN, Cui H, Li M, Dong X, Tao YX*. A long noncoding RNA contributes to neuropathic pain by silencing Kcna2 in primary afferent neurons. Nature Neuroscience. 2013 Aug; 16(8): 1024-31.

7.  Zhao JY#, Yang XY#, Shi KH#, Sun SN, Hou J, Ye ZZ, Wang J, Duan WY, Qiao B, Chen YJ, Shen HB, Huang GY, Jin L, Wang HY*. A functional variant in the cystathionine β-synthase gene promoter significantly reduces congenital heart disease susceptibility in a Han Chinese population. Cell Research. 2013, 23:242-53.

8.  Zhao JY#, Yang XY#, Gong XH#, Gu ZY, Duan WY, Wang J, Ye ZZ, Shen HB, Shi KH, Hou J, Huang GY, Jin L, Qiao B*, Wang HY*. Functional variant in methionine synthase reductase intron-1 significantly increases the risk of congenital heart disease in the Han Chinese population. Circulation. 2012 Jan 24; 125(3): 482-90.

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