赵健元

基本信息

职称:副研究员
电话:021-516
30422
邮箱:zhaojy@fudan.edu.cn
地址:复旦大学生命科学学院C321

个人简介

男,1980年出生,博士,副研究员。1999-2006年就读安徽大学生命科学学院,2003、2006分别获得生物技术专业学士学位和生化分子生物学专业硕士学位,2008-2011年就读复旦大学遗传学专业并获博士学位,2011-2013在美国约翰霍普金斯大学从事博士后研究,2013年9月作为人才引进回复旦大学工作,进行疾病的遗传和代谢生物学研究。

Bachelor degree in Biology technology in 2003, and Master degree in Biochemistry and Molecular Biology in 2006 from Anhui University. Ph.D. in Genetics from the Fudan University in 2011. Post-doctoral fellow at Johns Hopkins University from 2011 to 2013. Associate Professor at Fudan University since 2013.

 

主要研究方向 (Research Interests)

从遗传和代谢的角度研究人类重大出生缺陷(先天性心脏病、神经管畸形)和肿瘤的发病机制,发展新型的干预策略。目前主持863青年科学家专题、国家自然基金面上项目、上海市自然基金等项目,作为骨干参与国家973项目。

Using molecular genetics, biochemistry, metabonomics approaches to study the genetic and metabolic basis of human birth defects and cancers.

 

获奖情况 (Awards)

教育部自然科学一等奖(2014,排名第三)、上海市优秀博士论文(2014)、罗氏诊断研究奖(2013)。

 

代表性论文和专著 [Selected Publications; total 20]

  1. Jian-Yuan Zhao, Bin Qiao, Wen-Yuan Duan, Xiao-Hong Gong, Qian-Qian Peng, Song-Shan Jiang, Chen-Qi Lu, Yi-Jiang Chen, Hong-Bing Shen, Guo-Ying Huang, Li Jin, Hong-Yan Wang. Genetic variants reducing MTR gene expression increase risk of congenital heart disease in Han Chinese population. European Heart Journal 2014, 35: 733-742. (2013 IF=14.7)

  2. Ji-Tian Xu*, Jian-Yuan Zhao*(Co-first author), Xiuli Zhao*, Davinna Ligons, Vinod Tiwari, Fidelis E. Atianjoh, Chun-Yi Lee, Lingli Liang, Weidong Zang, Dolores Njoku, Srinivasa N. Raja, Myron Yaster, Yuan-Xiang Tao. Morphine tolerance and hyperalgesia mediated through μ opioid receptor-triggered mTORC1 activation in dorsal horn neurons. The Journal of Clinical Investigation 2014, 124(2): 592-603. (2013 IF=13.8)

  3. Xiuli Zhao*, Zongxiang Tang*, Hongkang Zhang*, Fidelis E. Atianjoh*, Jian-Yuan Zhao* (Co-first author), Lingli Liang, Wei Wang, Xiaowei Guan, Sheng-Chin Kao, Vinod Tiwari, Yong-Jing Gao, Paul N. Hoffman, Hengmi Cui, Min Li, Xinzhong Dong, Yuan-Xiang Tao. A native long noncoding RNA contributes to neuropathic pain by specifically silencing Kv1.2 in primary afferent neurons. Nature Neuroscience 2013, 16(8): 1024-31. (2013 IF=15.0)

  4. Jian-Yuan Zhao, Xue-Yan Yang, Kai-Hu Shi, Shu-Na Sun, Jia Hou, Zhi-Zhou Ye, Jue Wang, Wen-Yuan Duan, Yi-Jiang Chen, Hong-Bing Shen, Guo-Ying Huang, Li Jin, Hong-Yan Wang. A functional variant in the cystathionine β-synthase gene promoter significantly reduces congenital heart disease susceptibility in a Han Chinese population. Cell Research 2013, 23: 242-253. (2013 IF=12.0)

  5. Jian-Yuan Zhao, Xue-Yan Yang, Xiao-Hong Gong, Zhuo-Ya Gu, Wen-Yuan Duan, Jue Wang, Zhi-Zhou Ye, Hong-Bin Shen, Kai-Hu Shi, Jia Hou, Guo-Ying Huang, Li Jin, Bin Qiao, Hong-Yan Wang. A functional variant in MTRR intron-1 significantly increases risk of congenital heart disease in Han Chinese population. Circulation 2012, 125(3): 482-90. (2013 IF=15.0)

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