王磊

基本信息

 职称: 教授

 电话:021-54237860

 邮箱:wangleiwanglei@fudan.edu.cn

 地址:复旦大学生命科学学院

个人简介:

男,1982年生,复旦大学生命科学学院教授,博导。

 

主要研究方向:

人类生殖疾病的遗传学基础。利用分子遗传学手段寻找相关疾病致病基因,并利用细胞,动物模型对相关基因功能展开深入研究。迄今为止,发表SCI论文总计55篇,影响因子累计约292,累计被引用约498次。自2011年以来,以通讯作者在NEJMAm J Hum Genet, HMG,JMG等国际期刊上发表SCI论文20篇,影响因子总计约148。发现了首个基因突变导致人类卵子成熟障碍并揭示了其致病的分子机制,研究发表于国际顶级杂志NEJM上(NEJM,2016),NEJM杂志同期配发了专题评论,认为这是认识卵子成熟障碍机理迈出的第一步。

 

获奖情况:

全国妇幼健康科技奖自然科学二等奖,2015

教育部长江学者奖励计划-青年长江学者,2016

 

代表性成果:

  1. Ruizhi Feng*, Qing Sang*, Yanping Kuang*, Xiaoxi Sun*,Zheng Yan*, Shaozhen Zhang*, Juanzi Shi, Guoling Tian, Anna Luchniak, Yusuke Fukuda, Bin Li, Min Yu, Junling Chen,Yao Xu, Luo Guo, Ronggui Qu, Xueqian Wang, Zhaogui Sun, Miao Liu, Huijuan Shi, Hongyan Wang, Yi Feng, Ruijin Shao, Renjie Chai, Qiaoli Li, Qinghe Xing, Rui Zhang, Eva Nogales, Li Jin, Lin He, Mohan L. Gupta, Jr., Nicholas J. Cowan# and Lei Wang#. Mutations in TUBB8 and Human oocyte meiotic arrest. NEJM. 2016; 374:223-32. (#Corresponding author) (IF=59) (#Corresponding author)
  2. Yao Xu*, Yingli Shi*, Min Yu*, Jing Fu*, Ruizhi Feng, Qing Sang, Bo Liang, Biaobang Chen, Ronggui Qu, Bin Li, Zheng Yan, Xiaoyan Mao, Yanping Kuang, Li Jin, Lin He, Xiaoxi Sun# and Lei Wang#. Mutations in PADI6 causes female infertility characterized by early embryonic arrest. Am J Hum Genet. 2016, Sep 1;99(3):744-52. (#Corresponding author) (IF=10.8)
  3. Ruizhi Feng, Zheng Yan, Bin Li, Min Yu, Qing Sang, Guoling Tian,Yao Xu , Biaobang Chen, Ronggui Qu, Zhaogui Sun, Xiaoxi Sun, Li Jin, Lin He, Yanping Kuang, Nicholas J. Cowan and Lei Wang*. Mutations in TUBB8 cause a multiplicity of phenotype in human oocytes and early embryos. J Med Genet 2016, Oct;53(10):662-71. (*Corresponding author)  (IF=5.7) (Cover Story) (*Corresponding author)
  4. Sang Q, Zhang J, Feng R, Wang X, Li Q, Zhao X, Xing Q, Chen W, Du J, Sun S, Chai R, Liu D, Jin L, He L, Li H*, Wang L*. Ildr1b is essential for semicircular canal development, migration of the posterior lateral line primordium and hearing ability in zebrafish: implications for a role in the recessive hearing impairment DFNB42. Hum Mol Genet. 2014 Dec 1;23(23):6201-11. (IF=6.39(*Corresponding author)
  5. Sang Q, Yao Z, Wang H, Feng R, Wang H, Zhao X, Xing Q, Jin L, He L, Wu L, Wang L*. Identification of microRNAs in human follicular fluid: characterization of microRNAs that govern steroidogenesis in vitro and are associated with polycystic ovary syndrome in vivo.   J Clin Endocrinol Metab (IF=6.2. 2013 Jul;98 (7):3068-3079 (*Corresponding author) (This paper is awarded as International Award for publishing Excellence in JCEM in 2013
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