凌晨

基本信息
职称:青年研究员
电话:021-31246574
邮箱:lingchenchina@fudan.edu.cn
地址:复旦大学生命科学学院 C125室
个人简介
男,1986年出生,博士,青年研究员。2003-2007年就读复旦大学生命科学学院生物科学专业,2007-2011年在美国佛罗里达大学医学院小儿科作研究生,2011年获理学博士学位。2011-2016年在美国佛罗里达大学医学院小儿科任教,先后任助博士后、研究助理教授(2012)。2016-现在,在复旦大学生命科学学院遗传学任青年研究员,从事遗传疾病与肿瘤基因治疗、病毒学等研究工作。
主要研究方向 (Research Interests)
血友病、地中海贫血症等遗传疾病的基因治疗。肝癌的基因治疗。腺相关病毒基础生物学研究。
获奖情况 (Awards)
2016年上海市东方学者特聘教授;2011年美国霍华德休斯研究院-佛罗里达大学优秀博士生奖;
课题组骨干
钟晨 邮箱:zhongchen@fudan.edu.cn。
代表性成果(*共同第一作者,#通讯作者)
- Li M#*, Tang Y*, Wu L*, Mo F, Wang X, Li H, Qi R, Zhang H, Srivastava A, and Ling C#. (2017) Hepatocyte-specific HNF4α/miR-122 pathway contributes to the iron-overload mediated hepatic inflammation. Blood. 130(8):1041-1051. PMID: 28655781.
- Lu JM, Liu DD, Li ZY, Ling C#, and Mei YA#. (2017) Neuritin Enhances Synaptic Transmission in Medial Prefrontal Cortex in Mice by Increasing CaV3.3 Surface Expression. Cerebral Cortex. 4:1-14. PMID: 28475719.
- Ling C*, Bhukhai K*, Yin Z*, Tan M, Yoder M, Leboulch P#, Payen E# and Srivastava A#. (2016) High-Efficiency Transduction of Primary Human Hematopoietic Stem/Progenitor Cells by AAV6 Vectors: Strategies for Overcoming Donor-Variation and Implications in Genome Editing. Scientific Reports. Accepted.
- Ling C#, Li B, Ma W, Srivastava A. (2016) Development of Optimized AAV Serotype Vectors for High-Efficiency Transduction at Further Reduced Doses. Human Gene Therapy Methods. 27(4):143-9.
- Sayroo R, Nolasco D, Yin Z, Cortes C. Y, Pandya M, Ling C# & Aslanidi G#. (2015) Development of novel AAV serotype 6 based vectors with selective tropism for human cancer cells. Gene Therapy. 23(1):18-25. PMID: 26270885.
- Li S*, Ling C*, Zhong L*, Li M, Su Q, He R, Tang Q, Greiner L. D, Shultz D. L, Brehm A. M, Flotte R. T, Mueller C, Srivastava A#, & GaoG#. (2015) Efficient and targeted transduction of nonhuman primate liver with systemically delivered optimized AAV3B vectors. Molecular Therapy. 23(12):1867-76. PMID: 26403887; PMCID: PMC4700112. *Co-first author.
- Li B*, Ma W*, Ling C*, Vliet V. K, Huang L, Agbandje-McKenna M, Srivastava A#, and Aslanidi V. G#. (2015) Site-directed mutagenesis of surface-exposed lysine residues leads to improved transduction by AAV2, but not AAV8 vectors in murine hepatocytes in vivo. Human Gene Therapy Methods. 26(6):211-220. PMID: 26421998; PMCID: PMC4677520. *Co-first author.
- Ling C, Wang Y, Lu Y, Wang L, Jayandharan G, Aslanidi V. G, Li B, Cheng B, Ma W, Lentz T, Ling CQ, Xiao X, Samulski R. J, Muzyczka N & Srivastava A#. (2015) The Adeno-Associated Virus Genome Packaging Puzzle. Journal of Molecular and Genetic Medicine. 9:175. doi:10.4172/1747-0862.1000175.
- Ling C*, Wang Y*, Feng YL, Zhang YN, Li J, Hu XR, Wang LN, Zhong MF, Zhai XF, Zolotukhin I, Srivastava A# & Ling CQ#. (2015) Prevalence of neutralizing antibodies against liver-tropic adeno-associated virus serotype vectors in 100 healthy Chinese and its potential relation to body constitutions. Journal of Integrative Medicine, 13(5):341-6. PMID: 26343106. PMID: 26343106. *Co-first author.
- Pandya M, Britt K, Hoffman B, Ling C# & Aslanidi G#. (2015) Reprogramming immune response with capsid-optimized AAV6 vectors for immunotherapy of cancer. Journal of Immunotherapy, 38(7):292-8. PMID: 26261893; PMCID: PMC4535186.
- Wang L, Yin Z, Wang Y, Lu Y, Zhang D, Srivastava A, Ling CQ, Aslanidi GV# & Ling C#. (2015) Productive life cycle of the adeno-associated virus 2 in the complete absence of a conventional polyadenylation signal. Journal of General Virology, 96(9):2780-7. PMID: 26297494; PMCID: PMC4635500.
- Ling C#*, Wang Y*, Lu Y, Wang LN, Jayandharan G, Aslanidi V. G, Li B, Cheng B, Ma W, Lentz T, Ling CQ, Xiao X, Samulski R. J, Muzyczka N & Srivastava A#. (2015) Enhanced transgene expression from recombinant single-stranded AAV vectors in human cell lines in vitro and in murine hepatocytes in vivo. Journal of Virology, 89(2):952-61. PMID: 25355884; PMCID: PMC4300666. *Co-first author.
- Ling C#*, Wang Y*, Zhang YH, Ejjigani A, Yin Zifei, Lu Y, Wang LN, Wang M, Li Jun, Hu Z, Aslanidi GV, Zhong Li, Gao G, Srivastava A# & Ling CQ#. (2014) Selective in vivo targeting of human liver tumors by optimized AAV3 vectors in a murine xenograft model. Human Gene Therapy, 25(12):1023-34. PMID: 25296041; PMCID: PMC4270149. *Co-first author.
- Zhang YH, Wang Y, Yusufali A, Ashby F, Zhang D, Yin ZF, Aslanidi V. G, Srivastava A, Ling CQ# & Ling C#. (2014) Cytotoxic Genes from Traditional Chinese Medicine Inhibit Tumor Growth both in vitro and in vivo. Journal of Integrative Medicine, 12(6):483-94. PMID: 25412666.
- Wang L, Wang Y, Yin Z, Zhang Y, Aslanidi G, Srivastava A, Ling CQ# and Ling C#. (2014) Pristimerin enhances recombinant adeno-associated virus vector-mediated transgene expression in human cell lines in vitro and murine hepatocytes in vivo. Journal of Integrative Medicine, 12(1):20-34. PMID: 24461592.
- Cheng B*, Ling C*, Dai Y, Lu Y, Glushakova L.G, Gee S.W.Y., McGoogan K.E., Aslanidi G.V., Park M, Stacpoole P.W., Siemann D, Liu C, Srivastava A# & Ling CQ# (2012). Development of optimized AAV3 serotype vectors: Mechanism of high-efficiency transduction of human liver cancer cells. Gene Therapy, 19(4): 375-84. PMID: 21776025; PMCID: PMC3519243. *Co-first author.
- Wang Y*, Ling C*, Song L, Wang L, Aslanidi G, Tan M, Ling CQ# & Srivastava A#. (2012). Limitations of encapsidation of recombinant scAAV2 genomes in different serotype capsids and their quantitation. Human Gene Therapy Methods, 23(4):225-33. PMID: 22966785; PMCID: PMC4015078. *Co-first author.
- Ling C, Lu Y, Cheng B, McGoogan KE, Gee SW, Ma W, Li B, Aslanidi GV & Srivastava A#. (2011). High-efficiency transduction of liver cancer cells by recombinant adeno-associated virus serotype 3 vectors. Journal of Visualized Experiments, 22(49). PMID: 21445055; PMCID: PMC3197307.
- Ling C, Lu Y, Kelsi JK, Jayandharan GR, Li B, Ma W, Cheng B, Gee SW, McGoogan KE, Govindasamy L, Zhong L, Agbandje-McKenna M & Srivastava A#. (2010). Human Hepatocyte Growth Factor Receptor is a Cellular Co-Receptor for AAV3. Hum Gene Therapy, 21(12), 1741-1747. PMID: 20545554; PMCID: PMC2999576.
- Ling C#. (2004) Effects of Purslane Herb on Stress Ability of Aging Mice Induced by D-galactose. Zhong Xi Yi Jie He Xue Bao. 2(5), 361-363. PMID: 15383260.