赵冰

职称:青年研究员

电话:021-31246582

邮箱:bingzhao@fudan.edu.cn

地址:复旦大学生命科学学院A501-4室

个人简介

男,1987年出生,博士、青年研究员、博士生导师。2005-2008年就读于中国农业大学生命科学试验班并获得学士学位;2008-2013年就读于清华大学生命科学学院并获得博士学位;2013-2015年于清华-北大生命科学联合中心进行博士后研究;2015-2017于美国辛辛那提儿童医院医学中心从事博士后研究;2017年起任复旦大学生命科学学院青年研究员。

 

主要研究方向

利用小鼠遗传、类器官模型,研究关键细胞信号与染色质重塑交互决定成体干细胞命运的功能机制,并发展类器官构建新策略。现作为首席科学家承担国家重点研发计划“干细胞及转化研究”重点专项(青年项目)。

 

获奖情况

国家优秀青年基金(2020)

“东方学者”特聘教授(2019)

上海市青年拔尖人才(2018)

上海市青年科技启明星(A类)(2018)

生命科学学院院长奖(2018)

AMGEN Postdoctoral Award(2015)

北京市优秀博士毕业生(2013)

 

代表性成果

1. Sun S, Jiang N, Jiang Y, He Q, He H, Wang X, Yang L, Li R, Liu F, Lin X* and Zhao B*. (2020) Chromatin remodeler Znhit1 preserves hematopoietic stem cell quiescence by determining the accessibility of distal enhancers. Leukemia, doi: 10.1038/s41375-020-0988-5. (* co-corresponding author)

2. Zhao B*, Ni C, Gao R, Wang Y, Yang L, Wei J, Lv T, Liang J, Zhang Q, Xu W, Xie Y, Wang X, Yuan Z, Liang J*, Zhang R* and Lin X*. (2020) Recapitulation of SARS-CoV-2 infection and cholangiocyte damage with human liver ductal organoids. Protein & Cell, doi: 10.1007/s13238-020-00718-6

3. Wang X, Ni C, Jiang N, Wei J, Liang J, Zhao B* and Lin X*. (2020) Generation of liver bipotential organoids with a small-molecule cocktail. Journal of Molecular Cell Biology, mjaa010.

4. Wei J, Ran G, Wang X, Jiang N, Liang J, Lin X*, Ling C* and Zhao B*. (2019) Gene manipulation in liver ductal organoids by optimized recombinant adeno-associated virus vectors. Journal of Biological Chemistry, 294(38):14096-14104.

5. Zhao B*, Chen Ying, Jiang N, Yang L, Sun S, Zhang Y, Wen Z, Ray L, Liu H, Hou G and Lin X*. (2019) Znhit1 controls intestinal stem cell maintenance by regulating H2A.Z incorporation. Nature Communications, 10:1071.

6. Qi Z, Li Y, Zhao B, Xu C, Liu Y, Li H, Zhang B, Wang X, Yang X, Xie W, Li B, Han JJ and Chen YG*. (2017) BMP restricts intestinal Lgr5+ stem cell self-renewal by directly suppressing its signature genes. Nature Communications, 8:13824.

7. Zhao B, Qi Z, Li Y, Wang C, Fu W and Chen YG*. (2015) The non-muscle-myosin-II heavy chain Myh9 mediates colitis-induced epithelium injury by restricting Lgr5+ stem cells. Nature Communications, 6:7166.

8. Lin L, Liu L, Zhao B, Xie R, Lin W, Li H, Li Y, Shi M, Chen YG, Springer TA and Chen X*. (2015) Carbon nanotube-assisted optical activation of TGF-β signalling by near-infrared light. Nature Nanotechnology, 10(5):465-71.       

9. Cui HK#, Zhao B#, Li Y, Guo Y, Hu H, Liu L* and Chen YG*. (2013) Design of stapled α-helical peptides to specifically activate Wnt/β-catenin signaling. Cell Research, 23:581-584. (# co-first author)

10. Zhao B, Wang Q, Du J, Luo S, Xia J and Chen YG*. (2012) PICK1 promotes caveolin-dependent degradation of TGF-β type I receptor. Cell Research, 22:1467-1478.

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