Thomas A. Steitz

诺贝尔化学奖得主

耶鲁大学教授

霍华德·休斯医学研究所研究员

复旦大学名誉教授

个人简介(Personal Profile

托马斯·施泰茨 (Thomas A. Steitz)1940年出生于美国威斯康星州的密尔沃基,1962年本科毕业于劳伦斯大学化学系。1966年获得哈佛大学分子生物学和生物化学博士学位,1967年-1970年在剑桥大学MRC分子生物学实验室作博士后。1970年加入耶鲁大学至今,现为耶鲁大学分子生物物理学和生物化学系的斯特林教授,以及霍华德·休斯医学研究所的研究员。2009年,因对核糖体结构和功能的研究而与文卡特拉曼·拉马克里希南和阿达·约纳特共同获得2009年诺贝尔化学奖。

Dr. Steitz was born in Milwaukee, Wisconsin in 1940. He received a B.A. degree in chemistry in 1962 from Lawrence College in Appleton, Wisconsin, and a Ph.D. degree in molecular biology and biochemistry in 1966 from Harvard, with William Lipscomb. He did the postdoctoral research as a Jane Coffin Childs Postdoctoral Fellow at the MRC Laboratory of Molecular Biology at the University of Cambridge during 1967–1970. Dr. Steitz joined the Yale faculty in 1970, where he has remained. In 2009, he was awarded the Nobel Prize in Chemistry along with Venkatraman Ramakrishnan and Ada Yonath "for studies of the structure and function of the ribosome".

 

主要研究方向 (Research Interests)

使用结构生物学和生物化学研究参与分子生物学中心法则过程(DNA复制、转录和翻译)的蛋白质核酸复合物机器的结构和工作机理。

Using structural biology and biochemistry to determine the detailed molecular mechanisms by which the proteins and nucleic acids involved in the central dogma of molecular biology (DNA replication, transcription, and translation) achieve their biological functions.

 

获奖情况 (Awards)
  • Foreign Member, the Royal Society (2011)
  • Nobel Prize in Chemistry (2009)
  • Gairdner International Award (2007)
  • Keio Medical Science Prize (2006)
  • AAAS Newcomb Cleveland Prize (2001)
  • Rosenstiel Award for Distinguished Work in Basic Medical Research (2001)
  • Member, National Academy of Sciences (1990)
  • Pfizer Award in Enzyme Chemistry (1980)
代表性论文和专著 [Selected Publications; total 340+]

1. Gagnon, M. G., Lin, J. & Steitz, T. A. (2016). Elongation factor 4 remodels the A-site tRNA on the ribosome. PNAS 113, 4994–4999

2. Lin, J., Gagnon, M.G., Bulkley, D., Steitz, T.A. (2015). Conformational changes of elongation factor G on the ribosome during tRNA translocation. Cell 160, 219-227.

3. Gagnon, M.G., Lin, J., Bulkley, D., Steitz, T.A. (2014). Crystal structure of elongation factor 4 bound to a clockwise ratcheted ribosome. Science 345, 684-687.

4. Lomakin, I., Steitz, T.A. (2013). The initiation of mammalian protein synthesis and mRNA scanning mechanism. Nature 500, 307-311.

5. Zuo, Y., Wang, Y., Steitz, T.A. (2013). The mechanism of E. coli RNA polymerase regulation by ppGpp is suggested by the structure of their complex. Mol Cell 50(3), 430-436.

6. Polikanov, Y.I., Blaha, G.M. Steitz, T.A. (2012). How Hibernation Factors RMF, HPF, and YfiA Turn Off Protein Synthesis. Science 336, 915-918.

7. Itsathitphaisarn, O., Wing, R.A., Eliason, W.K., Wang, J., Steitz, T.A. (2012). The Hexameric Helicase DnaB Adopts a Nonplanar Conformation during Translocation. Cell 151, 267-277.

8. Gagnon, M.G., Seetharaman, S.V., Bulkley, D., Steitz, T.A. (2012). Structural basis for the rescue of stalled ribosomes: structure of YaeJ bound to the ribosome. Science 335, 1370-1372.

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