Jeremy Kirk Nicholson

帝国理工学院医学部外科学与肿瘤系教授

复旦大学名誉教授

个人简介(Personal Profile

Jeremy Kirk Nicholson (杰里米·柯克·尼科尔森)教授,男,1956年出生,博士,教授。1977年毕业于英国利物浦大学海洋生物学专业,获学士学位;1980年获伦敦大学省托马斯医院生物化学博士学位。1980-1981年在伦敦大学伯贝克学院化学系从事博士后研究,后升任讲师;1992-1998年任伯贝克学院化学系生物化学教授;1998年起到帝国理工学院医学部工作,历任生物化学系主任(1998-2007)、生物分子医学系主任(2007-2009),现为帝国理工学院医学部外科学与肿瘤系教授。2016年11月任复旦大学生命科学学院名誉教授。

Prof Jeremy Nicholson finished his Bachelor’s degree in marine biology at the University of Liverpool, UK in 1977 and obtained PhD in biochemistry at St Thomas’ Hospital Medical School, University of London in 1980. He was an RTZ post-doctoral research fellow during 1980-1981 at Department of Chemistry, Birkbeck College, University of London, where his career as Lecturer began and became Professor in Biological Chemistry in 1992. He joined Faculty of Medicine, Imperial College London as Professor of Biological Chemistry in 1998 and worked as Head of Biological Chemistry (1998-2007) and Head of Department of Biomolecular Medicine (2007-2009). He is currently Professor in Department of Surgery and Cancer, Faculty of Medicine, Imperial College London. He earned Honorary Professorship in the School of Life Sciences, Fudan University in November, 2016.

 

BSc Honours Marine Biology, University of Liverpool, UK (1977)

PhD, Biochemistry, St Thomas' Hospital Med School, University of London (1980)

RTZ Post-doctoral Research Fellow, Department of Chemistry, Birkbeck College, University of London (1980)

Lecturer in Chemistry, Dept. of Chemistry, Birkbeck College, University of London (1981)

Professor in Biological Chemistry, Dept of Chemistry, Birkbeck College, University of London (1992)

Head of Biological Chemistry, Biomedical Sciences Division, Faculty of Medicine, Imperial College London (1998 – 2007)

Head of Department of Biomolecular Medicine, Division of Surgery, Oncology, Reproductive Biology and Anaesthetics, Faculty of Medicine, Imperial College London (2007 – 2009)

Chair in Biological Chemistry, Head of Department of Surgery & Cancer, Faculty of Medicine, Imperial College London (2009 –  )

 

主要研究方向 Research Interests

在分子层面上研究与代谢和医学相关的物理、化学过程;利用波谱学和化学计量学手段,为人类疾病和毒理过程研究开发新型方法;基于代谢的自上而下的系统生物学及复杂系统衰竭的建模;代谢表型与系统医学指导的个性化医疗;外科代谢组学,实时诊断及病患综合建模;

 

Molecular physico-chemical processes in metabolism and medicine

Development of novel spectroscopic and chemometric tools for investigating human disease and toxicological mechanisms

Metabolism-driven top-down systems biology and modelling of complex system failure

Personalised healthcare through metabolic phenotyping and systems medicine

Surgical metabonomics, real-time diagnostics and integrative patient modeling

 

获奖情况 Awards

曾获皇家化学会分析科学银奖、分析化学统计与计量金奖、辉瑞全球化学领域奖等。

The Royal Society of Chemistry: 21st Silver Medal for Analytical Science (1992)

The Chromatographic Society: Jubilee Silver Medal (1994)

The Royal Society of Chemistry: 21st SAC Gold Medal for Analytical Chemistry (1997)

Pfizer Academic Innovation Award for Chemical and Medicinal Technology (2002)

The Royal Society of Chemistry: Silver Medal for Chemical Biology (2003)

Pfizer Global Chemistry Discipline Prize (2006)

The Royal Society of Chemistry Interdisciplinary Award (2008)

NIH: Stars in Cancer and Nutrition Distinguished Lecturer (2010)

Semmelweis - Budapest Prize (2010)

Robert Zhong Award in Surgery (Canada) (2013)

 

代表性论文和专著 Selected Publications

 

1. Nicholson, J. K.*, Kendall, M. D., Osborn, D.* 1983. Cadmium and Mercury Nephrotoxicity. Nature 304:633-635.

2. Brindle, J. T., Antti, H., Holmes, E., Tranter, G., Nicholson, J. K., Bethell, H. W. L., Clarke, S., Schofield, P. M., McKilligin, E., Mosedale, D. E., Grainger, D. J.* 2002. Rapid and Noninvasive Diagnosis of the Presence and Severity of Coronary Heart Disease Using 1H-NMR-Based Metabonomics. Nature Medicine 8:1439-1444.

3. Nicholson, J. K.*, Connelly, J., Lindon, J. C., Holmes, E. 2002. Metabonomics: A Platform for Studying Drug Toxicity and Gene Function. Nature Reviews Drug Discovery 1:153-161.

4. Nicholson, J. K.*, Wilson, I. D. 2003. Understanding 'Global' Systems Biology: Metabonomics and the Continuum of Metabolism. Nature Reviews Drug Discovery 2:668-676.

5. Nicholson, J. K.*, Holmes, E., Lindon, J. C., Wilson, I. D. 2004. The Challenges of Modeling Mammalian Biocomplexity. Nature Biotechnology 22:1268-1274.

6. Wang, Y. L., Holmes, E., Nicholson, J. K., Cloarec, O., Chollet, J., Tanner, M., Singer, B. H., Utzinger, J*. 2004. Metabonomic Investigations in Mice Infected with Schistosoma Mansoni: An Approach for Biomarker Identification. Proc. Natl. Acad. Sci. USA 101:12676-12681.

7. Lindon, J. C.*, Nicholson, J. K., Holmes, E., Keun, H. C., Craig, A., Pearce, J. T. M., Bruce, S. J., Hardy, N., Sansone, S. A., Antti, H., Jonsson, P., Daykin, C., Navarange, M., Beger, R. D., Verheij, E. R., Amberg, A., Baunsgaard, D., Cantor, G. H., Lehman-McKeeman, L., Earll, M., Wold, S., Johansson, E., Haselden, J. N., Kramer, K., Thomas, C., Lindberg, J., Schuppe-Koistinen, I., Wilson, I. D., Reily, M. D., Robertson, D. G., Senn, H., Krotzky, A., Kochhar, S., Powell, J., van der Ouderaa, F., Plumb, R., Schaefer, H., Spraul, M. 2005. Summary Recommendations for Standardization and Reporting of Metabolic Analyses. Nature Biotechnology 23:833-838.

8. Nicholson, J. K.*, Holmes, E., Wilson, I. D. 2005. Gut Microorganisms, Mammalian Metabolism and Personalized Health Care. Nature Reviews Microbiology 3:431-438.

9. Clayton, T. A., Lindon, J. C., Cloarec, O., Antti, H., Charuel, C., Hanton, G., Provost, J. P., Le Net, J. L., Baker, D., Walley, R. J., Everett, J. R., Nicholson, J. K.* 2006. Pharmaco-Metabonomic Phenotyping and Personalized Drug Treatment. Nature 440:1073-1077.

10. Dumas, M. E.*, Barton, R. H., Toye, A., Cloarec, O., Blancher, C., Rothwell, A., Fearnside, J., Tatoud, R., Blanc, V., Lindon, J. C., Mitchell, S. C., Holmes, E., McCarthy, M. I., Scott, J., Gauguier, D., Nicholson, J. K.* 2006. Metabolic Profiling Reveals a Contribution of Gut Microbiota to Fatty Liver Phenotype in Insulin-Resistant Mice. Proc. Natl. Acad. Sci. USA 103:12511-12516.

11. Beckonert, O., Keun, H. C., Ebbels, T. M. D., Bundy, J. G., Holmes, E., Lindon, J. C., Nicholson, J. K.* 2007. Metabolic Profiling, Metabolomic and Metabonomic Procedures for NMR Spectroscopy of Urine, Plasma, Serum and Tissue Extracts. Nature Protocols 2:2692-2703.

12. Dumas, M. E., Wilder, S. P., Bihoreau, M. T., Barton, R. H., Fearnside, J. F., Argoud, K., D'Amato, L., Wallis, R. H., Blancher, C., Keun, H. C., Baunsgaard, D., Scott, J., Sidelmann, U. G., Nicholson, J. K.*, Gauguier, D.* 2007. Direct Quantitative Trait Locus Mapping of Mammalian Metabolic Phenotypes in Diabetic and Normoglycemic Rat Models. Nature Genetics 39:666-672.

13. Holmes, E., Loo, R. L., Stamler, J., Bictash, M., Yap, I. K. S., Chan, Q., Ebbels, T., De Iorio, M., Brown, I. J., Veselkov, K. A., Daviglus, M. L., Kesteloot, H., Ueshima, H., Zhao, L., Nicholson, J. K.*, Elliott, P*. 2008. Human Metabolic Phenotype Diversity and Its Association with Diet and Blood Pressure. Nature 453:396-U50 .

14. Holmes, E., Wilson, I. D., Nicholson, J. K.* 2008. Metabolic Phenotyping in Health and Disease. Cell 134:714-717.

15. Jia, W.*, Li, H., Zhao, L., Nicholson, J. K. 2008. Gut Microbiota: A Potential New Territory for Drug Targeting. Nature Reviews Drug Discovery 7:123-129.

16. Li, M., Wang, B., Zhang, M., Rantalainen, M., Wang, S., Zhou, H., Zhang, Y., Shen, J., Pang, X., Zhang, M., Wei, H., Chen, Y., Lu, H., Zuo, J., Su, M., Qiu, Y., Jia, W., Xiao, C., Smith, L. M., Yang, S., Holmes, E., Tang, H.*, Zhao, G.*, Nicholson, J. K.*, Li, L.*, Zhao, L.* 2008. Symbiotic Gut Microbes Modulate Human Metabolic Phenotypes. Proc. Natl. Acad. Sci. USA 105:2117-2122.

17. Nicholson, J. K.*, Lindon, J. C.* 2008. Systems Biology - Metabonomics. Nature 455:1054-1056.

18. Wang, Y., Utzinger, J., Saric, J., Li, J. V., Burckhardt, J., Dirnhofer, S., Nicholson, J. K., Singer, B. H., Brun, R., Holmes, E.* 2008. Global Metabolic Responses of Mice to Trypanosoma Brucei Brucei Infection. Proc. Natl. Acad. Sci. USA 105:6127-6132.

19. Clayton, T. A., Baker, D., Lindon, J. C., Everett, J. R., Nicholson, J. K.* 2009. Pharmacometabonomic Identification of a Significant Host-Microbiome Metabolic Interaction Affecting Human Drug Metabolism. Proc. Natl. Acad. Sci. USA 106:14728-14733.

20. Beckonert, O., Coen, M., Keun, H. C., Wang, Y., Ebbels, T. M. D., Holmes, E., Lindon, J. C., Nicholson, J. K.* 2010. High-Resolution Magic-Angle-Spinning NMR Spectroscopy for Metabolic Profiling of Intact Tissues. Nature Protocols 5:1019-1032.

21. Want, E. J.*, Wilson, I. D., Gika, H., Theodoridis, G., Plumb, R. S., Shockcor, J., Holmes, E., Nicholson, J. K. 2011. Global Metabolic Profiling Procedures for Urine Using UPLC-MS. Nature Protocols 5:1005-1018.

22. Chan, E. C. Y.*, Pasikanti, K. K., Nicholson, J. K. 2011. Global Urinary Metabolic Profiling Procedures Using Gas Chromatography-Mass Spectrometry. Nature Protocols 6:1483-1499.

23. Swann, J. R., Want, E. J., Geier, F. M., Spagou, K., Wilson, I. D., Sidaway, J. E., Nicholson, J. K.*, Holmes, E.* 2011. Systemic Gut Microbial Modulation of Bile Acid Metabolism in Host Tissue Compartments. Proc. Natl. Acad. Sci. USA 108:4523-4530.

24. Holmes, E., Kinross, J., Gibson, G. R., Burcelin, R., Jia, W., Pettersson, S., Nicholson, J. K.* 2012. Therapeutic Modulation of Microbiota-Host Metabolic Interactions. Science Translational Medicine 4:137rv6.

25. Kinross, J.*, Nicholson, J. K. 2012. Gut Microbiota Dietary and Social Modulation of Gut Microbiota in the Elderly. Nature Reviews Gastroenterology & Hepatology 9:563-564.

26. Nicholson, J. K.*, Holmes, E., Kinross, J., Burcelin, R., Gibson, G., Jia, W., Pettersson, S.* 2012. Host-Gut Microbiota Metabolic Interactions. Science 336:1262-1267.

27. Nicholson, J. K.*, Holmes, E., Kinross, J. M., Darzi, A. W., Takats, Z., Lindon, J. C. 2012. Metabolic Phenotyping in Clinical and Surgical Environments. Nature 491:384-392.

28. Balog, J., Sasi-Szabo, L., Kinross, J., Lewis, M. R., Muirhead, L. J., Veselkov, K., Mirnezami, R., Dezso, B., Damjanovich, L., Darzi, A., Nicholson, J. K.*, Takats, Z.* 2013. Intraoperative Tissue Identification Using Rapid Evaporative Ionization Mass Spectrometry. Science Translational Medicine 5:194ra93.

29. Smith, M. I., Yatsunenko, T., Manary, M. J., Trehan, I., Mkakosya, R., Cheng, J., Kau, A. L., Rich, S. S., Concannon, P., Mychaleckyj, J. C., Liu, J., Houpt, E., Li, J. V., Holmes, E., Nicholson, J., Knights, D., Ursell, L. K., Knight, R., Gordon, J. I.* 2013. Gut Microbiomes of Malawian Twin Pairs Discordant for Kwashiorkor. Science 339:548-554 .

30. Swann, J. R., Spagou, K., Lewis, M., Nicholson, J. K., Glei, D. A., Seeman, T. E., Coe, C. L., Goldman, N., Ryff, C. D., Weinstein, M., Holmes, E.* 2013. Microbial-Mammalian Cometabolites Dominate the Age-Associated Urinary Metabolic Phenotype in Taiwanese and American Populations. Journal of Proteome Research 12:3166-3180 .

31. Zheng, X., Zhao, A.*, Xie, G., Chi, Y., Zhao, L., Li, H., Wang, C., Bao, Y., Jia, W., Luther, M., Su, M., Nicholson, J. K., Jia, W.* 2013. Melamine-Induced Renal Toxicity Is Mediated by the Gut Microbiota. 2013. Science Translational Medicine 5:172ra22.

32. Veselkov, K. A.*, Mirnezami, R., Strittmatter, N., Goldin, R. D., Kinross, J., Speller, A. V. M., Abramov, T., Jones, E. A., Darzi, A., Holmes, E., Nicholson, J. K., Takats, Z. 2014. Chemo-Informatic Strategy for Imaging Mass Spectrometry-Based Hyperspectral Profiling of Lipid Signatures in Colorectal Cancer. Proc. Natl. Acad. Sci. USA 111:1216-1221.

33. Elliott, P.*, Posma, J. M., Chan, Q., Garcia-Perez, I., Wijeyesekera, A., Bictash, M., Ebbels, T. M. D., Ueshima, H., Zhao, L., van Horn, L., Daviglus, M., Stamler, J., Holmes, E., Nicholson, J. K.* 2015. Urinary Metabolic Signatures of Human Adiposity. Science Translational Medicine 7:285ra62.

34. O'Keefe, S. J. D.*, Li, J. V., Lahti, L., Ou, J., Carbonero, F., Mohammed, K., Posma, J. M., Kinross, J., Wahl, E., Ruder, E., Vipperla, K., Naidoo, V., Mtshali, L., Tims, S., Puylaert, P. G. B., DeLany, J., Krasinskas, A., Benefiel, A. C., Kaseb, H. O., Newton, K., Nicholson, J. K., de Vos, W. M., Gaskins, H. R., Zoetendal,  Fat, E. G. 2015. Fat, Fibre and Cancer Risk in African Americans and Rural Africans. Nature Communications 6:6342.

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