洪尚宇

基本信息

职称:青年研究员
电话:
shangyu_hong@fudan.edu.cn
邮箱:Mhan@colorado.edu
地址:复旦大学生命科学学院

 

 
个人简介:

1997-2001 武汉大学生科院 学士;

2001-2006 中科院上海生科院生化细胞所 博士;

2006-2010 哈佛医学院神经生物学系 博士后;

2010-2015 哈佛医学院Beth Israel Deaconess Medical Center Research Fellow;

2015-2017 哈佛医学院 Brigham and Women’s Hospital Research Fellow;

2017-至今 复旦大学生科院 青年研究员。

 

主要研究方向:
  1. 研究饮食与营养代谢相关基因的交互作用;
  2. 研究肝脏和脂肪组织糖脂代谢平衡与代谢性疾病发病机制。

 

代表性成果:
  1. Shangyu Hong, Jose M Moreno-Navarrete, Xiaojing Wei, Yusuke Kikukawa, Iphigenia Tzameli, Deepthi Prasad, Yoonjin Lee, John M Asara, Jose Manuel Fernandez- Real, Eleftheria Maratos-Flier and Pavlos Pissios. Nicotinamide N-methyltransferase regulates hepatic nutrient metabolism through Sirt1 protein stabilization. Nat Med. 2015 Aug;21(8):887-94. Selected for preview in Cell Metab 2015 Aug 4;22(2):200-1.
  2. Alexander M. Real*, Shangyu Hong* and Pavlos Pissios. Nicotinamide N-Oxidation by CYP2E1 in Human Liver Microsomes. Drug Metab Dispos. 2013 41 (3), 550-553 (*authors contributed equally to this work).
  3. Shangyu Hong, HairongHuo, Jinfei Xu and Kan Liao. Insulin-Like Growth Factor-1 Receptor Signaling in 3T3-L1 Adipocyte Differentiation Requires Lipid Rafts But Not Caveolae. Cell Death Differ 2004 Jul;11(7):714-23.
  4. Wei Song, Daojun Cheng, Shangyu Hong, Benoit Sappe, Yanhui Hu, Neil Wei, Changqi Zhu, Michael B. O’Connor, Pavlos Pissios and Norbert Perrimon. Midgut-derived activin regulates glucagon-like action in the fat body and glycemic control. Cell Metab. 2017 25(2), 386-399.
  5. Pavlos Pissios, Shangyu Hong, Adam Richard Kennedy, Deepthi Prasad, Fen-Fen Liu, Eleftheria Maratos-Flier. Methionine and choline regulate the metabolic phenotype of a ketogenic diet. Mol Metab. 2013 (2): 306-313.
  6. Maria V. Gelfand, Shangyu Hong and Chenghua Gu. Guidance from above: common cues direct distinct signaling outcomes in vascular and neural patterning. Trends Cell Biol. 2009 Mar;19(3):99-110.
  7. Yao Yao, Shangyu Hong, Hu Zhou, Taichang Yuan, Rong Zeng and Kan Liao. The differential protein and lipid compositions of noncaveolar lipid microdomains and caveolae. Cell Res. 2009 Apr;19(4):497-506.
  8. Taichang Yuan, Shangyu Hong, Yao Yao and Kan Liao. Glut-4 is translocated to both caveolae and non-caveolar lipid rafts, but is partially internalized through caveolae in insulin-stimulated adipocytes. Cell Res. 2007 Sep;17(9):772-82.
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