洪尚宇

基本信息

职称:青年研究员

电话:021-31246765

邮箱:shangyu_hong@fudan.edu.cn

地址:复旦大学生命科学学院楼C113

 

 
个人简介:

2001年本科毕业于武汉大学生科院,2007年博士毕业于中科院上海生科院生化细胞所,毕业后于哈佛大学医学院进行博士后研究,2017年受聘复旦大学生科院任研究员(青年),独立PI。

 

主要研究方向:

1. 研究饮食与营养代谢相关基因的交互作用;

2. 研究肝脏和脂肪组织糖脂代谢稳态与代谢性疾病发病机制。

 

获奖情况:

2018 上海市浦江人才

2014 波士顿营养与肥胖研究中心奖学金

2006 谈家桢九源奖学金

2004 中国科学院院长优秀奖

2004 上海-联合利华奖学金

1997 武汉大学校长特别奖

 

代表性成果:

1. Hong S#, Zhai B and Pissios P#, Nicotinamide N-Methyltransferase Interacts with Enzymes of the Methionine Cycle and Regulates Methyl Donor Metabolism. Biochemistry. 2018 Sep 18. doi: 10.1021/acs.biochem.8b00561. (#共同通讯作者)

2. Hong S, Song W, Zushin PH, Liu B, Jedrychowski MP, Mina AI, Deng Z, Cabarkapa D, Hall JA, Palmer CJ, Aliakbarian H, Szpyt J, Gygi SP, Tavakkoli A, Lynch L, Perrimon N, Banks AS. Phosphorylation of Beta-3 adrenergic receptor at serine 247 by ERK MAP kinase drives lipolysis in obese adipocytes. Mol Metab. 2018 Jun;12:25-38.

3. Hong S, Moreno-Navarrete JM, Wei X, Kikukawa Y, Tzameli I, Prasad D, Lee Y, Asara JM, Fernandez-Real JM, Maratos-Flier E, Pissios P. Nicotinamide N-methyltransferase regulates hepatic nutrient metabolism through Sirt1 protein stabilization. Nat Med. 2015 Aug;21(8):887-94.

4. Real AM*, Hong S* and Pissios P. Nicotinamide N-Oxidation by CYP2E1 in Human Liver Microsomes. Drug Metab Dispos. 2013 41 (3), 550-553 (*共同一作).

5. Hong S, Huo H, Xu J and Liao K. Insulin-Like Growth Factor-1 Receptor Signaling in 3T3-L1 Adipocyte Differentiation Requires Lipid Rafts But Not Caveolae. Cell Death Differ. 2004 Jul;11(7):714-23.

6. Song W, Cheng D, Hong S, Sappe B, Hu Y, Wei N, Zhu C, O’Connor MB, Pissios P and Perrimon N. Midgut-derived activin regulates glucagon-like action in the fat body and glycemic control. Cell Metab. 2017 25(2), 386-399.

7. Pissios P, Hong S, Kennedy AR, Prasad D, Liu FF, Maratos-Flier E. Methionine and choline regulate the metabolic phenotype of a ketogenic diet. Mol Metab. 2013 (2): 306-313.

8. Yao Y, Hong S, Zhou H, Yuan T, Zeng R and Liao K. The differential protein and lipid compositions of noncaveolar lipid microdomains and caveolae. Cell Res. 2009 Apr;19(4):497-506.

9. Yuan T, Hong S, Yao Y and Liao K. Glut-4 is translocated to both caveolae and non-caveolar lipid rafts, but is partially internalized through caveolae in insulin-stimulated adipocytes. Cell Res. 2007 Sep;17(9):772-82.

Copyright © 2014 School of Life Sciences Fudan University All Rights Reserved
联系地址:上海市淞沪路2005号