桑庆

基本信息

职称:副研究员
电话:021-54237620
邮箱:sangqing@fudan.edu.cn
地址:复旦大学生命科学学院A601-5室

个人简介

男,1983年出生,博士,副研究员。2007-2010年获中山大学硕士学位。2010-2013获复旦大学博士学位,主修遗传学,2013-2015于复旦大学生物医学研究院从事博士后研究。2015年12月至今,任职于复旦大学生命科学学院,从事出生缺陷的遗传学研究。

 

主要研究方向 (Research Interests)

女性生殖疾病的遗传学基础:(1)多囊卵巢综合症(PCOS)的遗传机制研究;(2)卵子成熟障碍及受精障碍相关致病基因鉴定并利用细胞及动物模型对相关基因功能展开深入研究。

 

获奖情况 (Awards)

国家优秀青年基金(2018)

复星奖教金一等奖(2017)

全国妇幼健康科技奖自然科学一等奖(2017,排名第二)

中国动物学会生殖生物学分会第二届青年科技奖(2017)

全国妇幼健康科技奖自然科学二等奖(2015,排名第二)

 

代表性成果

1. Qing Sang#*, Bin Lin*, Xueqian Wang*, Zhihua Zhang*, Biaobang Chen*, Ling Wu,Qingfeng Lyu Zheng Yan, Xiaoyan Mao, Yao Xu, Jian Mu, Qiaoli Li, Li Jin, Lin He, Lei Wang#. Homozygous Mutations in WEE2 Cause Fertilization Failure and Female Infertility. Am J Hum Genet, 2018 Apr 5;102(4):649-657

2. Biaobang Chen*, Zhihua Zhang*, Xiaoxi Sun*, Yanping Kuang*, Xiaoyan Mao*, Xueqian Wang, Zheng Yan, Bin Li, Yao Xu, Min Yu, Jing Fu, Jian Mu, Zhou Zhou, Qiaoli Li, Li Jin, Lin He, Qing Sang# and Lei Wang#. Biallelic mutations in PATL2 cause female infertility characterized by oocyte maturation arrest. Am J Hum Genet, 2017,Oct 5;101(4):609-615

3. Chen B, Li B, Li D, Yan Z, Mao X, Xu Y, Mu J, Li Q, Jin L, He L, Kuang Y, Sang Q*, Wang L*. Novel mutations and structural deletions in TUBB8: expanding mutational and phenotypic spectrum of patients with arrest in oocyte maturation, fertilization or early embryonic development. Hum Reprod. 2017 Feb;32(2):457-464

4. Ruizhi Feng*, Qing Sang*, Yanping Kuang*, Xiaoxi Sun*,Zheng Yan*, Shaozhen Zhang*, Juanzi Shi, Guoling Tian, Anna Luchniak, Yusuke Fukuda, Bin Li, Min Yu, Junling Chen,Yao Xu, Luo Guo, Ronggui Qu, Xueqian Wang, Zhaogui Sun, Miao Liu, Huijuan Shi, Hongyan Wang, Yi Feng, Ruijin Shao, Renjie Chai, Qiaoli Li, Qinghe Xing, Rui Zhang, Eva Nogales, Li Jin, Lin He, Mohan L. Gupta, Jr., Nicholas J. Cowan# and Lei Wang#. Mutations in TUBB8 and Human oocyte meiotic arrest. N Engl J Med. 2016; 374:223-32.

5. Sang Q, Zhang J, Feng R, Wang X, Li Q, Zhao X, Xing Q, Chen W, Du J, Sun S, Chai R, Liu D, Jin L, He L, Li H*, Wang L*. Ildr1b is essential for semicircular canal development, migration of the posterior lateral line primordium and hearing ability in zebrafish: implications for a role in the recessive hearing impairment DFNB42. Hum Mol Genet. 2014 Dec 1;23(23):6201-11.

6. Sang Q*, Yao Z*, Wang H*, Feng R, Wang H, Zhao X, Xing Q, Jin L, He L, Wu L, Wang L*. Identification of microRNAs in human follicular fluid: characterization of microRNAs that govern steroidogenesis in vitro and are associated with polycystic ovary syndrome in vivo. J Clin Endocrinol Metab. 2013 Jul;98 (7):3068-3079.

7. Qing Sang*, Shaozhen Zhang*, Sien Zhou, Ruizhi Feng, Lei Wang*. Quantitative analysis of follistatin (FST) promoter methylation in peripheral blood of patients with polycystic ovary syndrome. Reprod Biomed Online.2013 Feb;26(2):157-63.

8. Sang Q*, Li W*, Xu Y, Qu R, Xu Z, Feng R, Jin L, He L, Li H, Wang L*. ILDR1 deficiency causes degeneration of cochlear outer hair cells and disrupts the structure of the organ of Corti: a mouse model for human DFNB42. Biol Open. 2015 Mar 27;4(4):411-8

9. Sang Q*, Mei H*, Kuermanhan A, Feng R, Guo L, Qu R, Xu Y, Li H, Jin L, He L, Wang L*. Identification of a novel compound heterozygous mutation in PTPRQ in a DFNB84 family with prelingual sensorineural hearing impairment. Mol Genet Genomics. 2015 Jun;290(3):1135-9.

10. Zou S*, Sang Q*, Wang H, Feng R, Li Q, Zhao X, Xing Q, Jin L, He L, Wang L*. Common genetic variation in CYP1B1 is associated with concentrations of T₄, FT₃ and FT₄ in the sera of polycystic ovary syndrome patients. Mol Biol Rep. 2013 Apr;40 (4):3315-20.

 

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