刘凌峰

基本信息

职称:青年研究员/博士生导师

邮箱:lingfengliu@fudan.edu.cn

地址:复旦大学生命科学学院

个人简介

1998.09~2003.06     复旦大学上海医学院/公共卫生学院 预防医学专业 医学学士

2003.09~2008.07     复旦大学生命科学学院/遗传学研究所/遗传工程国家重点实验室   哲学博士

2008.10~2011.12     美国弗莱德.哈钦森癌症研究中心 基础医学研究部 博士后

2012.01~2017.07     美国弗莱德.哈钦森癌症研究中心 临床医学研究部   助理研究员

2017.08~2018.08     美国华盛顿大学医学中心 访问学者/教授

2017.08~至今          福建医科大学附属协和医院  特聘教授

2018.09~至今          复旦大学生命科学学院/复旦大学人类表型组研究院  青年研究员/博士生导师

2018.09~至今          复旦大学附属中山医院 客座教授

 

主要研究方向 (Research Interests)

精准医学领域:免疫细胞治疗,细胞工程设计及免疫细胞表型研究

 

代表性成果(Recent representative publications)

1.  Liu L & Riddell SR; Tagged chimeric effector molecules and receptors thereof.  Publication number WO2015095895 A1; Application number PCT/US2014/072007

 

2. Liu L, Riddell SR & Hoffstrom BG Development of high-affinity Strep-tag II monoclonal antibodies for multiple functionalities and use with genetically modified cells. (Serial NO: 62/555,017/US Filing date: 9/6/2017)

 

3. Liu L, Riddell SR, Busch DH & Fräßle SP Development of chimeric receptors that are specific for strep-tag II and uses thereof (Serial NO: 62/555,012/US Filing date: 9/6/2017)

 

4. Liu L, Sommermeyer D, Cabanov A, Kosasih P, Hill T, Riddell SR Inclusion of Strep-tag II in design of antigen receptors for T-cell immunotherapy. Nature Biotechnology. 2016 Apr;34(4):430-4. F1000Prime » Article Recommendations

 

5. Liu L & Eisenman RN., Regulation of c-Myc Protein Abundance by a Protein Phosphatase 2A Glycogen Synthase Kinase 3 Negative Feedback Pathway, Genes & Cancer. 2012 Jan;3(1):23-36

 

6. Salter AI, Ivey RG, Kennedy JJ, Voillet V, Rajan A, Alderman EJ, Voytovich UJ, Lin C, Sommermeyer D, Liu L, Whiteaker JR, Gottardo R, Paulovich AG, Riddell SR Phosphoproteomic analysis of chimeric antigen receptor signaling reveals kinetic and quantitative differences that affect cell function. Science Signaling. 2018 Aug 21;11(544)

 

7. Paszkiewicz PJ, Fräßle SP, Srivastava S, Sommermeyer D, Hudecek M, Drexler I, Sadelain M, Liu L, Jensen MC, Riddell SR, Busch DH. Targeted antibody-mediated depletion of murine CD19 CAR T cells permanently reverses B cell aplasia. J Clin Invest. 2016 Nov 1; 126 (11):4262-4272.

 

8. Michael Hudecek‡, Daniel Sommermeyer‡, Paula L. Kosasih, Anne Silva, Lingfeng Liu, Christoph Rader, Michael C. Jensen, Stanley R. Riddell The non-signaling extracellular spacer domain of CD19- specific chimeric antigen receptors is decisive for in vivo antitumor activity. Cancer Immunol Res. 2015 Feb;3(2):125-35

 

9. Riddell SR, Sommermeyer D, Berger C, Liu Lingfeng, Balakrishnan A, Salter A, Hudecek M, Maloney DG, Turtle CJ, Adoptive therapy with chimeric antigen receptor-modified T cells of defined subset composition. Cancer J. 2014 Mar-Apr; 20(2):141-4

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