闫致强

基本信息

职称:教授
电话:021-516
30753
邮箱:zqyan@fudan.edu.cn
地址:复旦大学生命科学学院 D207室

Address: 2005 Songhu Road, School of life Sciences, Fudan University, Shanghai, China, 200438

Lab Website: http://www.neuron.fudan.edu.cn/

 

 

个人简介

男,博士生导师,研究员,2004年获复旦大学学士学位,  2004-2009年分别于中国科学院神经科学研究所,北京生命科学研究所以及中科院生物物理研究所进行博士研究并获得博士学位,2009-2014于加州大学旧金山分校及霍华德.休斯医学研究所的詹裕农(Yuh-Nung  Jan,美国科学院院士)实验室进行博士后研究。博士后期间获得人类前沿科学项目奖金(Human  Frontier Science program long term fellowship)。2014年初任复旦大学生命科学学院研究员、博士生导师。获得上海高校特聘教授(东方学者),  上海市青年科技启明星等奖项。BMC Neuroscience  (IF:2.67) 编委,上海市神经学会理事,中国神经学会离子通道专业委员会委员。

 

Education and research experience:

09/2000-06/2004: B.S. in Biology, Fudan University, Shanghai, China

09/2004-12/2005: Graduate student, Institute of Neuroscience, Chinese Academy of Sciences, Shanghai, China

12/2005-06/2009: Ph.D. in Neurobiology, National Institute of Biology Sciences, Beijing & Institute of Biophysics, Chinese Academy of Sciences, Beijing, China

06/2009-2013/11: Postdoctoral researcher with Yuh Nung Jan, Howard Hughes Medical Institute, Department of Physiology, University of California at San Francisco, San Francisco, USA

2013/11-Present:  Professor, School of life Science, Fudan University, Shanghai, China

Appointment in Academic Journal:

BMC Neuroscience (IF:2.67) : Associate Editor,  2015/05 –now

 

主要研究方向 (Research Interests)

我们的基本的感觉中,嗅觉,视觉,味觉等的分子转导机制都很清楚,例如,嗅觉感觉的分子生物学转导机制的研究获得了2004年的诺贝尔奖。听觉,触觉的转导机制可以说比嗅觉的转导机制更加重要,但是其分子转导机制还是不清楚的。我们实验室把听觉,触觉作为我们研究的主要方向,力争在这个领域做出基础的,重要的,新颖的发现。据中国卫生部2012年报告,我国的新生儿的听力遗传缺陷达到千分之二左右,我国在2012年出生听力遗传缺陷儿童就有3.5万人。在进行基础科研的同时,我们也会在新生儿听力遗传缺陷的机理研究,以及其预防,诊断和治疗方向做出努力。

实验室欢迎学生,博士后和科研助理加盟。本实验室欢迎于学生博士后以及研究助理的讨论他们的职业理想和目标,并且与实验室的总体目标找到共通,帮助学生,博士后以及研究助理实现他们的职业理想和目标,实现一个共赢的,长期发展的目标。

 

MOLECULAR TRANSDUCION MECHANISM OF HEARING AND TOUCH

Mechanotransduction is the process by which mechanical force is transformed into neuronal signals, and is essential forhuman senses of touch, hearing and gravity rely on mechanosensation.Notwithstanding the importance of mechanosensation, its cellular and molecular mechanisms are the least well understood among the different sensory modalities. By combining Drosophila genetics, behavioral assays,electrophysiological recording and calcium imaging, we have demonstrated thatthe Drosophila NompC protein is apore-forming subunit of a mechanotransduction channel functioning in class IIIdendritic arborization (da) neurons to sense gentle touch (Yan et al, Nature, Jan 10, 2013). We will continue to use Drosophila  to study hearing and touch, and will extend our our wotk to mamalin system.

 

获奖情况 (Awards)

2015年,第六批青年千人计划

  2014年,上海高校特聘教授(东方学者)(上海市教委)

  2014年,上海市青年科技启明星(上海市科委)

 

Young 1000 Talent Program, (2015)

The Program for Professor of Special Appointment (Eastern Scholar of Shanghai), 2014

The Shanghai Rising-Star Program, 2014

Human Frontier Science Program (HFSP) Long-term Fellowship, 2010-2013

Graduate Student Excellence Award, National Institute of Biological Sciences, Beijing, 2008

 

代表性成果 (selected publications; total 27; * corresponding author)

1. Zhiqiang Yan, Wei Zhang, Ye He, David Gorczyca, Yang Xiang, Li E. Cheng, Shan Meltzer, Lily Yeh Jan, and Yuh Nung Jan* (2013). Drosophila NompC is a mechanotransduction channel subunit for gentle touch sensation. Nature, 493: 221–5.

2. Zhiqiang Yan, Jie Tan, Chang Qin, Yao Lu, Cheng Ding, Minmin Luo*(2008). Precise Circuitry Links Bilaterally Symmetric Olfactory Maps. Neuron,58: 613–24.

3. Wei Zhang, Zhiqiang Yan, Lily Yeh Jan, and Yuh Nung Jan*(2013). Sound response mediated by the TRP channels NOMPC, NANCHUNG, and INACTIVE in chordotonal organs of Drosophila larvae. Proc Natl Acad Sci U S A., 110:13612-7.

4. Wei Zhang#, Zhiqiang Yan#, Bingxue Li, Lily Yeh Jan, and Yuh Nung Jan*(2014).Identification of motor neurons and a mechanosensitive sensory neuron in the defecation circuitry of Drosophila larvae. eLife, 2014;3:e03293 (# equal contribution).

5. Joshua A. Bagley, Zhiqiang Yan, Wei Zhang, Jill Wildonger, Lily Yeh Jan, Yuh Nung Jan*(2014). Double-bromo and extraterminal (BET) domain proteins regulate dendrite morphology and mechanosensory function. Genes Dev. 28(17): 1940-56.

6. Quan Yuan, Yang Xiang, Zhiqiang Yan, Chun Han, Lily Yeh Jan & Yuh Nung Jan* (2011). Light induced Structural and Functional Plasticity in Drosophila Larval Visual System. Science, 333(6048): 1458-62.

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