Motoyuki Hattori

Basic Information

Title:

Phone:021- 5163 0740

Email:hattorim@fudan.edu.cn

Address:复旦大学生命科学学院 A201-2室

Introduction

   Motoyuki HATTORI (服部素之),Professor and PhD. Tutor at School of Life Sciences, Fudan University. 2005: B. A., Department of Biophysics and Biochemistry, University of Tokyo, 2009: Ph. D., Department of Biological Information, Tokyo Institute of Technology, 2009-2012: Postdoctoral Fellow, Oregon Health & Science University, 2012-2015: Research Associate, JST Researcher, Department of Biological Sciences, University of Tokyo

 

Research Interests

   Membrane proteins such as ion channels and transporters play a crucial role in various cell signaling processes, and represent more than half of targets for commercially available drugs. Accordingly, high-resolution 3D structures of membrane proteins are of great interest at the level of both basic science and drug discovery research.

   The Hattori Lab is interested in atomic-level understanding of the molecular mechanism of membrane proteins, particularly of those associated with human diseases. To achieve these goals, we employ X-ray crystallography to obtain 3D structures of our target membrane proteins, and then conduct structure-guided mutational analysis by a combination of electrophysiological and biochemical approaches. Open postdoc and student positions are currently available.

 

Awards

2007年,日本学术振兴会特别研究研究员奖学金。

2008年,默克公司青年生物化学研究员奖。

2008年,日本蛋白质科学学会青年科学家奖。

2010年,日本学术振兴会海外特别研究员奖学金。

2012年,上原纪念生命科学基金会出国留学奖学金。

2014年,上海市 第四批 “上海千人计划” 。

2015年, 第十一批青年千人计划

 

Achievements

1. Wang J, Wang Y, Cui WW, Huang Y, Yang Y, Liu Y, Zhao WS, Cheng XY, Sun WS, Cao P, Zhu MX, Wang R*, Hattori M*, Yu Y*."Druggable negative allosteric site of P2X3 receptors." Proc Natl Acad Sci U S A. 2018, pii: 201800907. *Corresponding authors.
2. Kasuya G, Yamaura T, Ma XB, Nakamura R, Takemoto M, Nagumo H, Tanaka E, Dohmae N, Nakane T, Yu Y, Ishitani R, Matsuzaki O*, Hattori M*, Nureki O*.  "Structural insights into the competitive inhibition of the ATP-gated P2X receptor channel." Nat Commun. 2017, 8(1):876. *Corresponding authors.
3. Tomita A, Zhang M, Jin F, Zhuang W, Takeda H, Maruyama T, Osawa M, Hashimoto KI, Kawasaki H, Ito K, Dohmae N, Ishitani R, Shimada I, Yan Z*, Hattori M*, Nureki O*.  "ATP-dependent modulation of MgtE in Mg2+ homeostasis." Nat Commun. 2017, 8(1):148. *Corresponding authors.
4. Kasuya G, Hiraizumi M, Maturana AD, Kumazaki K, Fujiwara Y, Liu K, Nakada-Nakura Y, Iwata S, Tsukada K, Komori T, Uemura S, Goto Y, Nakane T, Takemoto M, Kato HE, Yamashita K, Wada M, Ito K, Ishitani R, Hattori M*, Nureki O*.   "Crystal structures of the TRIC trimeric intracellular cation channel orthologues." Cell Res. 2016, (12):1288-1301. *Corresponding authors.
5. Kasuya G, Fujiwara Y, Takemoto M, Dohmae N, Nakada-Nakura Y, Ishitani R, Hattori M*, Nureki O*.  "Structural Insights into Divalent Cation Modulations of ATP-Gated P2X Receptor Channels." Cell Rep. 2016, 14(4):932-944. *Corresponding authors.
6. Hattori M and Gouaux E., “Molecular mechanism of ATP binding and ion channel activation P2X receptors.” Nature 2012, 485(7397) 207-212.
7. Hattori M, Tanaka Y, Fukai S, Ishitani R, Nureki O., “Crystal structure of the MgtE Mg2+ transporter.” Nature 2007, 448(7157) 1072-1075.

 

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