Motoyuki Hattori

Basic Information

Title:

Phone:021- 5163 0740

Email:hattorim@fudan.edu.cn

Address:复旦大学生命科学学院 A201-2室

Introduction

   Motoyuki HATTORI (服部素之),Professor and PhD. Tutor at School of Life Sciences, Fudan University. 2005: B. A., Department of Biophysics and Biochemistry, University of Tokyo, 2009: Ph. D., Department of Biological Information, Tokyo Institute of Technology, 2009-2012: Postdoctoral Fellow, Oregon Health & Science University, 2012-2015: Research Associate, JST Researcher, Department of Biological Sciences, University of Tokyo

 

Research Interests

   Membrane proteins such as ion channels and transporters play a crucial role in various cell signaling processes, and represent more than half of targets for commercially available drugs. Accordingly, high-resolution 3D structures of membrane proteins are of great interest at the level of both basic science and drug discovery research.

   The Hattori Lab is interested in atomic-level understanding of the molecular mechanism of membrane proteins, particularly of those associated with human diseases. To achieve these goals, we employ X-ray crystallography to obtain 3D structures of our target membrane proteins, and then conduct structure-guided mutational analysis by a combination of electrophysiological and biochemical approaches. Open postdoc and student positions are currently available.

 

Awards

2007年,日本学术振兴会特别研究研究员奖学金。

2008年,默克公司青年生物化学研究员奖。

2008年,日本蛋白质科学学会青年科学家奖。

2010年,日本学术振兴会海外特别研究员奖学金。

2012年,上原纪念生命科学基金会出国留学奖学金。

2014年,上海市 第四批 “上海千人计划” 。

2015年, 第十一批青年千人计划

 

Achievements

1. Hattori M and Gouaux E., “Molecular mechanism of ATP binding and ion channel activation P2X receptors.” Nature 2012, 485(7397) 207-212.

2. Hattori M*, Hibbs RE*, Gouaux E., “A fluorescence-detection size-exclusion chromatography-based thermostability assay for membrane protein precrystallization screening. “ Structure 2012, 20(8) 1293-1299 *Equally contribution

3. Hattori M*, Iwase N*, Furuya N*, Tanaka Y, Tsukazaki T, Ishitani R, Maguire ME, Ito K, Maturana A, Nureki O., “Mg2+-dependent gating of bacterial MgtE channel underlies Mg2+ homeostasis.” EMBO J 2009, 28(22) 3602-3612. *Equally contribution

4. Hattori M, Jin Y, Nishimasu H, Tanaka Y, Mochizuki M, Uchiumi T, Ishitani R, Ito K, Nureki O., “Structural basis of novel interactions between the small-GTPase and GDI-like domains in prokaryotic FeoB iron transporter.” Structure 2009, 17(10) (2009) 1345-1355.

5. Hattori M, Tanaka Y, Fukai S, Ishitani R, Nureki O., “Crystal structure of the MgtE Mg2+ transporter.” Nature 2007, 448(7157) 1072-1075.

6. Tanaka Y, Hipolito CJ, Maturana AD, Ito K, Kuroda T, Higuchi T, Katoh T, Kato HE, Hattori M, Kumazaki K, Tsukazaki T, Ishitani R, Suga H, Nureki O., “Structural basis for the drug extrusion mechanism by a MATE multidrug transporter.” Nature. 2013, 496(7444) 247-251.

 

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