教师基本信息：
姓名：焦娜
职称：青年研究员
电子邮箱：najiao@fudan.edu.cn
办公地点：江湾校区生命科学学院
研究方向：
微生物与宿主互作；
微生物资源挖掘；
微生物组学分析方法及平台开发
个人简介：
焦娜，青年研究员，博士生导师。2014年毕业于吉林大学获得工学学士学位，2019年在同济大学获得生物学博士（生物信息学方向），2019-2021年在中山大学附属第六医院进行博士后研究。2021-2023年在浙江大学医学院附属儿童医院国家儿童健康与疾病临床医学研究中心任特聘研究员，2024年1月入职复旦大学生科院微生物学与免疫学系，任青年研究员。研究聚焦于微生物与宿主互作、微生物资源挖掘和微生物组学分析方法及平台开发。近年来围绕微生物与慢病防治、微生物-宿主互作在Nature Microbiology、Nature Communications、Cell Reports Medicine、Gut和Gut Microbes等期刊上发表了多篇研究论文。入选博士后创新人才支持计划和获得国家自然科学基金青年科学基金项目资助。
招生专业：微生物学、生物信息学
科研项目：
• 国家自然科学基金青年科学基金项目，82000536，肠道菌群介导的胆汁酸代谢通过肠肝轴诱导NAFLD的病理机制探究，2021.01-2023.12，主持
• 高校基本科研业务费青年教师培育项目，20ykpy07，FUT基因突变型炎症性肠病中肠道菌群的改变及其介导的病理机制研究，2020.01-2021.01，主持
• 博士后科学基金面上资助，2019M663252，肠道菌群胆碱代谢在NAFLD发病机制中的作用研究，2020.01-2021.08，主持
• 博士后创新人才支持计划，BX20190393，非酒精性脂肪肝病发病机制中胆酸代谢菌种确定及个性化干预研究，2019.09-2021.08，主持
代表性论文和论著：
1. Xinyue Zhu#, Pingping Xu#, Ruixin Zhu*, Wenxing Gao, Wenjing Yin, Ping Lan, Lixin Zhu*, Na Jiao*, Multi-kingdom microbial signatures in excess body weight colorectal cancer based on global metagenomic analysis, Communications Biology, 2024, 10.1038/s42003-023-05714-0
2. Wenxing Gao#, Xiang Gao#, Lixin Zhu*, Sheng Gao, Ruicong Sun, Zhongsheng Feng, Dingfeng Wu, Zhanju Liu*, Ruixin Zhu*, Na Jiao*, Multimodal metagenomic analysis reveals microbial single nucleotide variants as superior biomarkers for early detection of colorectal cancer. Gut Microbes, 2023, 15(2):2245562.
3. Xiang Gao#, Ruicong Sun#, Na Jiao#, Xiao Liang, Gengfeng Li, Han Gao, Xiaohan Wu, Muqing Yang, Chunqiu Chen, Liang Chen, Wei Wu, Zhong Li, Yingzi Cong, Ruixin Zhu*, Tiannan Guo*, Zhanju Liu*, Integrative multi-omics deciphers the spatial characteristics of host-gut microbiota interactions in Crohn’s disease. Cell Reports Medicine. 2023;4, 101050.
4. Ningning Liu#, Na Jiao#, Jing-Cong Tan#, Ziliang Wang#, Dingfeng Wu, An-Jun Wang, Jie Chen, Liwen Tao, Chenfen Zhou, Wenjie Fang, Io Hong Cheong, Weihua Pan, Wanqing Liao, Zisis Kozlakidis, Christopher Heeschen, Geromy G. Moore, Lixin Zhu*, Xingdong Chen*, Guoqing Zhang*, Ruixin Zhu*, Hui Wang*. Multi-kingdom microbiota analyses identify bacterial-fungal interactions and biomarkers of colorectal cancer across cohorts. Nature Microbiology, 2022; 7(2):238-250. (ESI)
5. Dingfeng Wu#, Lei Liu#, Na Jiao#, Yida Zhang, Li Yang, Chuan Tian, Ping Lan, Lixin Zhu*, Rohit Loomba*, and Ruixin Zhu*. Targeting Keystone Species Helps Restore the Dysbiosis of Butyrate‐Producing Bacteria in Nonalcoholic Fatty Liver Disease. iMeta. 2022 1(4): e61
6. Yuqi Wu#, Na Jiao#, Ruixin Zhu*, Yida Zhang, Dingfeng Wu, An-Jun Wang, Sa Fang, Liwen Tao, Yichen Li, Sijing Cheng, Ping Lan, Chuan Tian*, Ning-Ning Liu*, Lixin Zhu*. Identification of microbial markers across populations in early detection of colorectal cancer. Nature Communications, 2021; 12(1):3063. (ESI)
7. Na Jiao, Susan S Baker*, Adrian Chapa-Rodriguez, Wensheng Liu, Colleen A Nugent, Maria Tsompana, Lucy Mastrandrea, Michael J Buck, Robert D Baker, Robert J Genco, Ruixin Zhu*, Lixin Zhu*. Suppressed hepatic bile acid signalling despite elevated production of primary and secondary bile acids in NAFLD. Gut. 2018; 67(10):1881-1891 (ESI)
8. Na Jiao#, Susan S. Baker, Colleen A. Nugent, Maria Tsompana, Liting Cai, Yong Wang, Michael J. Buck, Robert J. Genco, Robert D. Baker, Ruixin Zhu*, Lixin Zhu*. Gut microbiome may contribute to insulin resistance and systemic inflammation in obese rodents: a meta-analysis. Physiological Genomics. 2018; 50(4):244-254. (APSselectaward)
Research Focus:
Interactions Between Microbiota and Hosts;
Exploration and Mining of Microbiome;
Advancement and Development of Metagenomic Analysis Techniques and Platforms.
Personal Introduction:
Na Jiao, PI of Microbiome Systems Biology research group, doctoral supervisor. She graduated from Jilin University in 2014 with a Bachelor of Engineering degree and earned a Ph.D. in Biology (Bioinformatics) from Tongji University in 2019. She conducted postdoctoral research at the Sixth Affiliated Hospital of Sun Yat-sen University from 2019 to 2021. From 2021 to 2023, she served as a distinguished researcher at the National Clinical Research Center for Child Health and Diseases, Children's Hospital, Zhejiang University School of Medicine. In January 2024, she joined the Department of Microbiology and Immunology at Fudan University as a young researcher. Her research focuses on interactions between microbiota and hosts, exploration and mining of microbiome, and advancement and development of metagenomic analysis techniques and platforms. In recent years, she has published numerous research papers in prestigious journals such as Nature Microbiology, Nature Communications, Cell Reports Medicine, Gut, and Gut Microbes, primarily revolving around the prevention and treatment of chronic diseases through microbiome and host-microbiota interactions. She has been recognized in the Postdoctoral Innovative Talent Support Program and has received funding from the National Natural Science Foundation of China's Young Scientists Fund.
Admission Specialties: Microbiology, Bioinformatics.
Research Project:
• National Natural Science Foundation of China, Young Scientists Fund, 82000536, Mechanism for the gut microbiota-mediated bile acid metabolism promoting NAFLD pathogenesis via gut-liver axis, 2021-01 to 2023-12, PI
• Higher Education Institutions Fundamental Research Project, Young Teachers Training Programs, 20ykpy07, Altered gut microbiome and mechanism in FUT2 loss-of-function mutants in inflammatory bowel disease, 2020-01to 2021-01, PI
• China Postdoctoral Science Foundation, General Program, 2019M663252, Role of the choline metabolizing microbiota in the pathogenesis of non-alcoholic fatty liver disease, 2020-01to 2021-08，PI
• China Postdoctoral Science Foundation, Postdoctoral Innovative Talent Support Program, BX20190393, Identification of bile acid metabolizing bacteria and individualized intervention in the pathogenesis of nonalcoholic fatty liver disease, 2019-09 to 2021-08, PI
Representative Publications and Works:
• Xinyue Zhu#, Pingping Xu#, Ruixin Zhu*, Wenxing Gao, Wenjing Yin, Ping Lan, Lixin Zhu*, Na Jiao*, Multi-kingdom microbial signatures in excess body weight colorectal cancer based on global metagenomic analysis, Communications Biology, 2024, 10.1038/s42003-023-05714-0
• Wenxing Gao#, Xiang Gao#, Lixin Zhu*, Sheng Gao, Ruicong Sun, Zhongsheng Feng, Dingfeng Wu, Zhanju Liu*, Ruixin Zhu*, Na Jiao*, Multimodal metagenomic analysis reveals microbial single nucleotide variants as superior biomarkers for early detection of colorectal cancer. Gut Microbes, 2023, 15(2):2245562.
• Xiang Gao#, Ruicong Sun#, Na Jiao#, Xiao Liang, Gengfeng Li, Han Gao, Xiaohan Wu, Muqing Yang, Chunqiu Chen, Liang Chen, Wei Wu, Zhong Li, Yingzi Cong, Ruixin Zhu*, Tiannan Guo*, Zhanju Liu*, Integrative multi-omics deciphers the spatial characteristics of host-gut microbiota interactions in Crohn’s disease. Cell Reports Medicine. 2023;4, 101050.
• Ningning Liu#, Na Jiao#, Jing-Cong Tan#, Ziliang Wang#, Dingfeng Wu, An-Jun Wang, Jie Chen, Liwen Tao, Chenfen Zhou, Wenjie Fang, Io Hong Cheong, Weihua Pan, Wanqing Liao, Zisis Kozlakidis, Christopher Heeschen, Geromy G. Moore, Lixin Zhu*, Xingdong Chen*, Guoqing Zhang*, Ruixin Zhu*, Hui Wang*. Multi-kingdom microbiota analyses identify bacterial-fungal interactions and biomarkers of colorectal cancer across cohorts. Nature Microbiology, 2022; 7(2):238-250. (ESI)
• Dingfeng Wu#, Lei Liu#, Na Jiao#, Yida Zhang, Li Yang, Chuan Tian, Ping Lan, Lixin Zhu*, Rohit Loomba*, and Ruixin Zhu*. Targeting Keystone Species Helps Restore the Dysbiosis of Butyrate‐Producing Bacteria in Nonalcoholic Fatty Liver Disease. iMeta. 2022 1(4): e61
• Yuqi Wu#, Na Jiao#, Ruixin Zhu*, Yida Zhang, Dingfeng Wu, An-Jun Wang, Sa Fang, Liwen Tao, Yichen Li, Sijing Cheng, Ping Lan, Chuan Tian*, Ning-Ning Liu*, Lixin Zhu*. Identification of microbial markers across populations in early detection of colorectal cancer. Nature Communications, 2021; 12(1):3063. (ESI)
• Na Jiao, Susan S Baker*, Adrian Chapa-Rodriguez, Wensheng Liu, Colleen A Nugent, Maria Tsompana, Lucy Mastrandrea, Michael J Buck, Robert D Baker, Robert J Genco, Ruixin Zhu*, Lixin Zhu*. Suppressed hepatic bile acid signalling despite elevated production of primary and secondary bile acids in NAFLD. Gut. 2018; 67(10):1881-1891 (ESI)
• Na Jiao#, Susan S. Baker, Colleen A. Nugent, Maria Tsompana, Liting Cai, Yong Wang, Michael J. Buck, Robert J. Genco, Robert D. Baker, Ruixin Zhu*, Lixin Zhu*. Gut microbiome may contribute to insulin resistance and systemic inflammation in obese rodents: a meta-analysis. Physiological Genomics. 2018; 50(4):244-254. (APSselectaward)