焦石

发布时间:2021-10-11浏览次数:5101

教师基本信息

姓名:焦石

职称:青年研究员

电子邮箱:jiaoshi@fudan.edu.cn

办公地点:发育楼333


研究方向

肿瘤免疫的细胞信号机制

本团队以胃癌为切入点,重点围绕肿瘤免疫的细胞网络、细胞互作及信号机制展开研究。研究内容包括:1)揭示胃癌免疫应答的关键细胞类型和细胞互作网络,筛选发现新的免疫检查点分子;2)探索器官交流(如脑胃轴)过程中胃癌免疫应答的功能模式,并在此基础上探寻胃癌分子分型,揭示胃癌免疫微环境的时空异质性。


个人简介

国家优青/中科院青促会会员(优秀)

2002年在东南大学获医学学士学位。2005年在东南大学获硕士学位。2008年在中国疾病预防与控制中心获医学博士学位。2008-2012年在中科院上海生科院营养科学研究所进行博士后研究。2012-2020年在中科院上海生科院生化与细胞研究所(现分子细胞科学卓越中心)任职,先后任助理研究员 (2012年)、副研究员 (2014年)。2021年至今,在复旦大学生命科学学院任青年研究员。

迄今以第一或共同第一作者(14 篇,其中8 篇排名第一)、共同通讯作者(8 篇)以及其它作者身份在Cancer Cell 2篇)、Nature ImmunologyNature CommunicationsJournal of Experimental Medicine2篇)、Advance ScienceEMBO JournalCell ResearchOncogene等国际知名学术期刊上发表研究论文34 篇,累计影响因子近200,他引近900次,单篇最高他引超460次。主持国家基金委青年、面上、优青、重大研究计划(培育)以及中科院“先导”专项(子课题)等多个项目。入选中科院“青年创新促进会”(2014年),获得赛诺菲‐上海生科院优秀青年人才奖励(2014年),入选国家“优青”(2018年)及“青促会优秀会员”(2019年),并获得上海医学科技奖二等奖(2020年)等。


授课情况

癌生物学



科研项目

主持国家自然科学基金面上项目,重大研究计划培育等项目


代表性论著#Co-first authors; *Corresponding authors

1. Meng, Y. #, Ye, F. #, Nie, P. #, Zhao, Q. #, An, L., Wang, W., Qu, S., Shen, Z., Cao, Z., Zhang, X., Zhang, X., Jiao, S*., Wu, D*., Zhou, Z*., Wei, L*. Immunosuppressive CD10+ALPL+ neutrophils promote resistance to anti-PD-1 therapy in HCC by mediating irreversible exhaustion of T cells. J Hepatol. (2023). 79(6):1435-1449.

2. Jiao, S.#*, Li, C., Guo, F., Zhang, J., Zhang, H., Cao, Z., Wang, W., Bu, W., Lin, M. *, Lü, J. *, Zhou, Z*. SUN1/2 controls macrophage polarization via modulating nuclear size and stiffness. Nature Communications. (2023).14:6416.

3. Nie, P. #, Zhang, W#., Meng, Y. #, Lin, M., Guo, F., Zhang, H., Tong, Z., Wang, M., Chen, F., An, L., Tang, Y., Han, Y., Yu, R., Wang, W., Xu, Y., Wei, Li., Zhou, Z*.and Jiao, S. * A YAP/TAZ-CD54 axis is required for CXCR2-CD44- tumor-specific neutrophils to suppress gastric cancer. (2023). Protein & cell 14(7):513-31

4. An, L. #, Cao, Z. #, Nie, P., Zhang, H., Tong, Z., Chen, F., Tang, Y., Han, Y., Wang, W., Zhao, Z., Zhao, Q., Yang Y., Xu Y., Fang, G., Shi, L., Xu, H., Ma H., Jiao, S*. and Zhou, Z*. Combinatorial targeting of Hippo-STRIPAK and PARP elicits synthetic lethality in gastrointestinal cancers.J Clin Invest (2022). 132(9)

5. Zhang, H. #, Lin, M. #, Dong, C. #, Tang, Y., An, L., Ju, J., Wen, F., Chen, F., Wang, M., Wang, W.,Chen, M., Zhao, Y., Li, J., Hou, S. X., Lin, X., Hu, L., Bu, W., Wu, D., Li, L., Jiao, S.* and Zhou, Z*. (2021). An MST4-pbeta-Catenin(Thr40) Signaling Axis Controls Intestinal Stem Cell and Tumorigenesis. Adv Sci (Weinh) 8, 17 e2004850

6. Tang, Y. #, Fang, G. #, Guo, F. #, Zhang, H. #, Chen, X., An, L., Chen, M., Zhou, L., Wang, W., Ye, T., Zhou, L., Nie, P., Yu, H., Lin, M., Zhao, Y., Lin, X., Yuan, Z., Jiao, S.* and Zhou, Z*. (2020) Selective Inhibition of STRN3-Containing PP2A Phosphatase Restores Hippo Tumor-Suppressor Activity in Gastric Cancer. Cancer Cell 38, 115-128 e9

7. An, L. #, Nie, P. #, Chen, M. #, Tang, Y., Zhang, H., Guan, J., Cao, Z., Hou, C., Wang, W., Zhao, Y., Xu, H. *, Jiao, S.* and Zhou, Z*. (2020) MST4 kinase suppresses gastric tumorigenesis by limiting YAP activation via a non-canonical pathway. J Exp Med 217, 6 e20191817

8. Tang, Y.#, Chen, M. #, Zhou, L. #, Ma, J. #, Li, Y., Zhang, H., Shi, Z., Xu, Q., Zhang, X., Gao, Z., Zhao, Y., Cheng, Y., Jiao, S.* and Zhou, Z*. (2019) Architecture, substructures, and dynamic assembly of STRIPAK complexes in Hippo signaling. Cell Discov5, 3

9. Li, Y., Guan, J., Wang, W., Hou, C., Zhou, L., Ma, J., Cheng, Y., Jiao, S.* and Zhou, Z.* (2019) TRAF3-interacting JNK-activating modulator promotes inflammation by stimulating translocation of Toll-like receptor 4 to lipid rafts. J Biol Chem294, 2744-2756

10. Wang, T., Wang, D., Yu, H.*, Feng, B., Zhou, F., Zhang, H., Zhou, L., Jiao, S. and Li, Y.* (2018) A cancer vaccine-mediated postoperative immunotherapy for recurrent and metastatic tumors. Nat commun9, 1532

11. Sun, W. W., Jiao, S., Sun, L., Zhou, Z., Jin, X. and Wang, J. H. * (2018) SUN2 Modulates HIV-1 Infection and Latency through Association with Lamin A/C To Maintain the Repressive Chromatin. mBio9, 3 e02408-17

12. Jiao, S.#*, Guan, J.#, Chen, M., Wang, W., Li, C., Wang, Y., Cheng, Y. and Zhou, Z.* (2018) Targeting IRF3 as a YAP agonist therapy against gastric cancer. J Exp Med215, 699-718

13. Jiao, S., Li, C., Hao, Q., Miao, H., Zhang, L., Li, L. and Zhou, Z.* (2017) VGLL4 targets a TCF4-TEAD4 complex to coregulate Wnt and Hippo signalling in colorectal cancer. Nat Commun8, 14058 (Highlighted by F1000prime)

14. Wang, D., Wang, T., Liu, J., Yu, H.*, Jiao, S., Feng, B., Zhou, F., Fu, Y., Yin, Q., Zhang, P., Zhang, Z., Zhou, Z. and Li, Y. * (2016) Acid-Activatable Versatile Micelleplexes for PD-L1 Blockade-Enhanced Cancer Photodynamic Immunotherapy. Nano letters16, 5503-5513