教师基本信息
姓名：邓恋
职称：青年研究员/博士生导师
电子邮箱：denglian@fudan.edu.cn
办公地点：复旦大学江湾校区生命科学楼D615
Google Scholar: https://scholar.google.com/citations?hl=en&user=1waLr_UAAAAJ
个人简介
邓恋，复旦大学生命科学学院青年研究员，博士生导师。2017年获中国科学院大学计算生物学专业博士学位；同年入职中国科学院上海生命科学研究院，历任助理研究员、副研究员；2021年9月进入复旦大学生命科学学院，任青年研究员。
长期从事群体遗传学和基因组学研究，关注人群遗传适应及疾病演化基础，以第一作者或通讯作者在Nature, Nature Communications，National Science Review，Cell Reports，Molecular Biology and Evolution等国际知名期刊发表多篇研究论文，研究成果入选中国十大医学科技新闻（2023），获国际权威科普期刊《科学美国人》（Scientific American）专题报道（2026）。
担任国家自然科学基金面上项目和青年项目负责人，并作为课题骨干参与两项国家重点研发计划课题；2019年入选上海市青年科技英才“扬帆计划”；2020年获法国赛诺菲安万特-中科院上海生科院青年科技人才奖；2021年入选中国科学院青年创新促进会会员；2023年获上海生物信息学会青年新星奖。现任中国遗传学会青年委员会委员，上海人类学学会“分子人类学”专业委员会常务委员、上海市遗传学会青年委员会委员。
研究方向
遗传学/基因组学/计算生物学/生物信息学
1. 解码人群遗传多样性与适应性演化，依托多民族泛基因组解析人类遗传变异新维度。
2. 融合泛基因组与演化基因组学，解析复杂表型与疾病易感性和临床差异的遗传基础，揭示人类健康的演化医学机制。
授课情况
《基因组学》（国家级一流本科课程）
《Human Evolutionary Genetics》（本科荣誉课程，英文）
《书报讨论（人类生物学）》
《生物医学英语写作》
代表性成果
[1] Yueyang Ma, Boon-Peng Hoh, Shuhua Xu*, Lian Deng*. 2026. Gene-culture coevolution shapes olfactory receptor gene diversity in Orang Asli populations. Cell Reports. 45:117181
[2] Qianqian Zhang#, Jialong Li#, Haoyang Huang, Xuan Shang, Yuhua Ye, Wei Zhang, Peng Lin, Yi Gong, Boon-Peng Hoh, Qingming Luo, Tizhen Yan, Xinghua Pan, Mark Stoneking, Shuhua Xu, Xiangmin Xu*, Lian Deng*. 2025. Multi-centric origins and gene flow shape the diversity of β-thalassemia mutations in southern East Asia. Nature Communications. 16:10220
[3] Yang Gao#, Xiaofei Yang#, Hao Chen#, Xinjiang Tan#, Zhaoqing Yang#, Lian Deng#, Baonan Wang, Shuang Kong, Songyang Li, Yuhang Cui, Chang Lei, Yimin Wang, Yuwen Pan, Sen Ma, Hao Sun, Xiaohan Xhao, Yingbing Shi, Ziyi Yang, Dongdong Wu, Shaoyuan Wu, Xingming Zhao, Binyin Shi, Li Jin, Zhibin Hu, Chinese Pangenome Consortium (CPC), Yan Lu*, Jiayou Chu*, Kai Ye*, and Shuhua Xu*. 2023. A pangenome reference of 36 Chinese populations. Nature. 619:112-121.
[4] Lian Deng#, Yuwen Pan#, Yinan Wang, Hao Chen, Kai Yuan, Sihan Chen, Dongsheng Lu, Siti Shuhada Mokhtar, Thuhairah Abdul Rahman, Boon-Peng Hoh, Shuhua Xu*. 2022. Genetic connections and convergent evolution of tropical indigenous peoples in Asia. Molecular Biology and Evolution. 39(2):msab361
[5] Lian Deng#, Chao Zhang#, Kai Yuan#, Yang Gao#, Yuwen Pan,Xueling Ge, Yaoxi He, Yuan Yuan, Yan Lu, Xiaoxi Zhang, Hao Chen, Haiyi Lou, Xiaoji Wang, Dongsheng Lu, Jiaojiao Liu, Lei Tian, Qidi Feng, Asifullah Khan, Yajun Yang, Zi-Bing Jin, Jian Yang, Fan Lu, Jia Qu, Longli Kang, Bing Su, Shuhua Xu*. 2019. Prioritizing natural selection signals from the deep-sequencing genomic data suggests multi-variant adaptation in Tibetan highlanders. National Science Review. 6(6):1201–1222.
其他论文和论著
[1] Sihan Chen#, Die Tang#, Lian Deng*, and Shuhua Xu*. 2023. Asian-European differentiation of schizophrenia-associated genes driven by admixture and natural selection. iScience. 27(5):109560.
[2] Lian Deng, Bo Xie, Yimin Wang, Xiaoxi Zhang, and Shuhua Xu*. 2022. A protocol for applying a population-specific reference genome assembly to population genetics and medical studies. STAR Protocols. 3:101440
[3] Kai Yuan#, Xumin Ni#, Chang Liu#, Yuwen Pan#, Lian Deng#, Rui Zhang#, Yang Gao, Xuiling Ge, Jiaojiao Liu, Xixian Ma, Haiyi Lou, Taoyang Wu, Shuhua Xu*. 2021. Refining models of archaic–modern human admixture in Eurasia with ArchaicSeeker 2.0. Nature Communications. 12:6232
[4] Lian Deng, Shuhua Xu*. 2021. ‘Chapter 3: Population Genomics of High-Altitude Adaptation’ in Naruya Saitou, Evolution of the Human Genome II: Modern Human Dispersal. Springer, Japan. 67-100
[5] Boon-Peng Hoh#, Xiaoxi Zhang#, Lian Deng#, Kai Yuan, Chee-Wei Yew, Woei-Yuh Saw, Mohammad Zahirul Hoque, Farhang Aghakhanian, Maude E Phipps, Yik-Ying Teo, Vijay Kumar Subbiah*, Shuhua Xu*. 2020. Shared signature of recent positive selection on the TSBP1–BTNL2–HLA-DRA genes in five native populations from North Borneo. Genome Biology and Evolution. doi: 10.1093/gbe/evaa207.
[6] Lian Deng#, Haiyi Lou#, Xiaoxi Zhang#, Thiruvahindrapuram Bhooma, Dongsheng Lu, Christian R Marshall, Chang Liu, Bo Xie, Wanxing Xu, Lai-Ping Wong, Chee-Wei Yew, Aghakhanian Farhang, Rick Twee-Hee Ong, Mohammad Zahirul Hoque, Abdul Rahman Thuhairah, Bhak Jong, Maude E Phipps, Stephen W Scherer, Yik-Ying Teo, Subbiah Vijay Kumar*, Boon-Peng Hoh*, Shuhua Xu*. 2019. Analysis of five deep-sequenced trio-genomes of the Peninsular Malaysia Orang Asli and North Borneo populations. BMC Genomics. 20:842.
[7] Ouzhuluobu#, Yaoxi He#, Haiyi Lou#, Chaoying Cui#, Lian Deng#, Yang Gao, Wangshan, Zheng, Yongbo Guo, Xiaoji Wang, Zhilin Ning, Jun Li, Bin Li, Caijuan Bai，Baimakangzhuo，Gonggalanzi, Dejiquzong, Bianba, Duojizhuoma, Shiming Liu, Tianyi Wu, Shuhua Xu*, Xuebin Qi*, Bing Su*. 2019. De novo assembly of a Tibetan genome and identification of novel structural variants associated with high altitude adaptation. National Science Review. 7(2):391-402.
[8] Chee-Wei Yew#, Dongsheng Lu#, Lian Deng#, Lai-Ping Wong#, Rick Twee-Hee Ong, Yan Lu, Xiaoji Wang, Yushimah Yunus, Farhang Aghakhanian, Siti Shuhada Mokhtar, Mohammad Zahirul Hoque, Christopher Lok-Yung Voo, Thuhairah Abdul Rahman, Jong Bhak, Maude E. Phipps, Shuhua Xu, Yik-Ying Teo, Subbiah Vijay Kumar*, Boon-Peng Hoh*. 2018. Genomic structure of the native inhabitants of Peninsular Malaysia and North Borneo suggests complex human population history in Southeast Asia. Human Genetics. 137(2):161-173.
[9] Lian Deng and Shuhua Xu*. 2018. Adaptation of human skin color in various populations. Hereditas. 155:1.
[10] Lian Deng, Andres Ruiz-Linares, Shuhua Xu* & Sijia Wang*. 2016. Ancestry variation and footprints of natural selection along the genome in Latin American populations. Scientific Reports. 6:21766.
[11] Lian Deng, Boon-Peng Hoh, Dongsheng Lu, Woei-Yuh Saw, Rick Twee-Hee Ong, Anuradhani Kasturiratne, H. Janaka de Silva, Bin Alwi Zilfalil, Norihiro Kato, Ananda R. Wickremasinghe, Yik-Ying Teo & Shuhua Xu*. 2015. Dissecting the genetic structure and admixture of four geographical Malay populations. Scientific Reports. 5:14375.
[12] Lian Deng, Boon Peng Hoh, Dongsheng Lu, Ruiqing Fu, Maude E. Phipps, Shilin Li, Ab Rajab Nur‑Shafawati, Wan Isa Hatin, Endom Ismail, Siti Shuhada Mokhtar, Li Jin, Bin Alwi Zilfalil, Christian R. Marshall, Stephen W. Scherer, Fahd Al‑Mulla, Shuhua Xu*. 2014. The population genomic landscape of human genetic structure, admixture history and local adaptation in Peninsular Malaysia. Human Genetics. 133(9):1169-1185
[13] Wei Qian#, Lian Deng#, Dongsheng Lu, Shuhua Xu*. 2013. Genome-Wide Landscapes of Human Local Adaptation in Asia. PLoS One. 8(1):e54224.