教师基本信息
姓名：邓恋
职称：青年研究员
电子邮箱：denglian@fudan.edu.cn
办公地点：复旦大学江湾校区生命科学楼D615
邓恋，女，青年研究员，博士生导师。2017年获中国科学院大学计算生物学专业博士学位；同年入职中国科学院上海生命科学研究院（后更名为中国科学院上海营养与健康研究所），历任助理研究员、副研究员；2021年9月进入复旦大学生命科学学院，任青年研究员。长期从事群体遗传学和基因组学研究，在Molecular Biology and Evolution, Nature Communications，National Science Review，Nucleic Acids Research，Genome Biology，American Journal of Human Genetics等国际知名期刊发表多篇研究论文，担任国家自然科学基金面上项目和青年项目负责人，并作为课题骨干参与多项国家重点研发计划课题；2019年入选上海市青年科技英才“扬帆计划”；2020年获法国赛诺菲安万特-中科院上海生科院青年科技人才奖；2021年入选中国科学院青年创新促进会会员；现任上海人类学学会“分子人类学”专业委员会常务委员、上海市遗传学会青年委员会委员。
研究方向
群体遗传学/基因组学/计算生物学
1.人群遗传多样性和适应性进化
2.人类表型和疾病的遗传基础和演化历程
代表性论文和论著
[1] Lian Deng, Bo Xie, Yimin Wang, Xiaoxi Zhang, and Shuhua Xu*. 2022. A protocol for applying a population-specific reference genome assembly to population genetics and medical studies. STAR Protocols. 3:101440
[2] Lian Deng#, Yuwen Pan#, Yinan Wang, Hao Chen, Kai Yuan, Sihan Chen, Dongsheng Lu, Siti Shuhada Mokhtar, Thuhairah Abdul Rahman, Boon-Peng Hoh, Shuhua Xu*. 2022. Genetic connections and convergent evolution of tropical indigenous peoples in Asia. Molecular Biology and Evolution. 39(2):msab361
[3] Kai Yuan#, Xumin Ni#, Chang Liu#, Yuwen Pan#, Lian Deng#, Rui Zhang#, Yang Gao, Xuiling Ge, Jiaojiao Liu, Xixian Ma, Haiyi Lou, Taoyang Wu, Shuhua Xu*. 2021. Refining models of archaic–modern human admixture in Eurasia with ArchaicSeeker 2.0. Nature Communications. 12:6232
[4] Lian Deng, Shuhua Xu*. 2021. ‘Chapter 3: Population Genomics of High-Altitude Adaptation’ in Naruya Saitou, Evolution of the Human Genome II: Modern Human Dispersal. Springer, Japan. 67-100
[5] Boon-Peng Hoh#, Xiaoxi Zhang#, Lian Deng#, Kai Yuan, Chee-Wei Yew, Woei-Yuh Saw, Mohammad Zahirul Hoque, Farhang Aghakhanian, Maude E Phipps, Yik-Ying Teo, Vijay Kumar Subbiah*, Shuhua Xu*. 2020. Shared signature of recent positive selection on the TSBP1–BTNL2–HLA-DRA genes in five native populations from North Borneo. Genome Biology and Evolution. doi: 10.1093/gbe/evaa207.
[6] Lian Deng#, Haiyi Lou#, Xiaoxi Zhang#, Thiruvahindrapuram Bhooma, Dongsheng Lu, Christian R Marshall, Chang Liu, Bo Xie, Wanxing Xu, Lai-Ping Wong, Chee-Wei Yew, Aghakhanian Farhang, Rick Twee-Hee Ong, Mohammad Zahirul Hoque, Abdul Rahman Thuhairah, Bhak Jong, Maude E Phipps, Stephen W Scherer, Yik-Ying Teo, Subbiah Vijay Kumar*, Boon-Peng Hoh*, Shuhua Xu*. 2019. Analysis of five deep-sequenced trio-genomes of the Peninsular Malaysia Orang Asli and North Borneo populations. BMC Genomics. 20:842.
[7] Ouzhuluobu#, Yaoxi He#, Haiyi Lou#, Chaoying Cui#, Lian Deng#, Yang Gao, Wangshan, Zheng, Yongbo Guo, Xiaoji Wang, Zhilin Ning, Jun Li, Bin Li, Caijuan Bai，Baimakangzhuo，Gonggalanzi, Dejiquzong, Bianba, Duojizhuoma, Shiming Liu, Tianyi Wu, Shuhua Xu*, Xuebin Qi*, Bing Su*. 2019. De novo assembly of a Tibetan genome and identification of novel structural variants associated with high altitude adaptation. National Science Review. 7(2):391-402.
[8] Lian Deng#, Chao Zhang#, Kai Yuan#, Yang Gao#, Yuwen Pan,Xueling Ge, Yaoxi He, Yuan Yuan, Yan Lu, Xiaoxi Zhang, Hao Chen, Haiyi Lou, Xiaoji Wang, Dongsheng Lu, Jiaojiao Liu, Lei Tian, Qidi Feng, Asifullah Khan, Yajun Yang, Zi-Bing Jin, Jian Yang, Fan Lu, Jia Qu, Longli Kang, Bing Su, Shuhua Xu*. 2019. Prioritizing natural selection signals from the deep-sequencing genomic data suggests multi-variant adaptation in Tibetan highlanders. National Science Review. 6(6):1201–1222.
[9] Chee-Wei Yew#, Dongsheng Lu#, Lian Deng#, Lai-Ping Wong#, Rick Twee-Hee Ong, Yan Lu, Xiaoji Wang, Yushimah Yunus, Farhang Aghakhanian, Siti Shuhada Mokhtar, Mohammad Zahirul Hoque, Christopher Lok-Yung Voo, Thuhairah Abdul Rahman, Jong Bhak, Maude E. Phipps, Shuhua Xu, Yik-Ying Teo, Subbiah Vijay Kumar*, Boon-Peng Hoh*. 2018. Genomic structure of the native inhabitants of Peninsular Malaysia and North Borneo suggests complex human population history in Southeast Asia. Human Genetics. 137(2):161-173.
[10] Lian Deng and Shuhua Xu*. 2018. Adaptation of human skin color in various populations. Hereditas. 155:1.
[11] Lian Deng, Andres Ruiz-Linares, Shuhua Xu* & Sijia Wang*. 2016. Ancestry variation and footprints of natural selection along the genome in Latin American populations. Scientific Reports. 6:21766.
[12] Lian Deng, Boon-Peng Hoh, Dongsheng Lu, Woei-Yuh Saw, Rick Twee-Hee Ong, Anuradhani Kasturiratne, H. Janaka de Silva, Bin Alwi Zilfalil, Norihiro Kato, Ananda R. Wickremasinghe, Yik-Ying Teo & Shuhua Xu*. 2015. Dissecting the genetic structure and admixture of four geographical Malay populations. Scientific Reports. 5:14375.
[13] Lian Deng, Boon Peng Hoh, Dongsheng Lu, Ruiqing Fu, Maude E. Phipps, Shilin Li, Ab Rajab Nur‑Shafawati, Wan Isa Hatin, Endom Ismail, Siti Shuhada Mokhtar, Li Jin, Bin Alwi Zilfalil, Christian R. Marshall, Stephen W. Scherer, Fahd Al‑Mulla, Shuhua Xu*. 2014. The population genomic landscape of human genetic structure, admixture history and local adaptation in Peninsular Malaysia. Human Genetics.133(9):1169-1185
[14] Wei Qian#, Lian Deng#, Dongsheng Lu, Shuhua Xu*. 2013. Genome-Wide Landscapes of Human Local Adaptation in Asia. PLoS One. 8(1):e54224.