教师基本信息：
姓名：张智
职称：副高级
职务：青年副研究员
电子邮箱：z_zhang@fudan.edu.cn
办公地点：复旦大学江湾校区生科楼C117
办公电话：021-31246768
研究方向：
课题组主要研究中枢对能量代谢的神经调控，尤其专注于雌激素在下丘脑对体温、饮食和能量代谢的调节机制研究。以基因编辑的实验动物为模型，综合利用光、化学遗传学，神经钙成像，单细胞测序和行为学等方法，揭示大脑调节能量稳态的神经原理和对肥胖等代谢疾病的致病机理。
Research Interests:
We are interested in understanding the central role of the peripheral hormones, e.g. estrogens， in the regulation of body temperature, energy intake and energy expenditure.These studies can help us better understand how the brain controls our body weight and maintains our metabolic health.
个人简介：
张智，复旦大学生命科学学院青年副研究员。荷兰阿姆斯特丹大学博士，美国加州大学洛杉矶分校（UCLA）博士后。在Nature Communications, Nature metabolism, eLife 等杂志发表 SCI论文19篇。曾获美国女性健康研究会青年科学家奖、美国心脏协会博士后奖、UCLA博士后校长奖提名等奖励。现主持国家自然科学基金项目1项，任中国生物物理协会会员，Frontiers in Physiology特邀审稿人。
授课情况：
《生理前沿课》研究生课程（参与）
招生专业：
生理学，神经生物学等
代表性论文和论著：
1. Zhang Z, DiVittorio R. J, Joseph M. A, Correa M. S. The effects of estrogens on neural circuits that control temperature. Endocrinology. 2021; 162(8):bqab087. (Selected for “2020 Thematic Special Issue”).
2. Zhang Z, Park J. W, Ahn I. S., Diamante G., Sivakumar N., Arneson D. V., Yang X., van Veen, J. E.# and Correa, S. M#. Estrogen receptor alpha in the brain mediates tamoxifen-induced changes in physiology in mice. eLife. 2021;10:e63333. (eLife Highlight)
3. Zhang Z, Reis FMCV, He Y, Park JW, DiVittorio JR, Sivakumar N, van Veen JE, Pereira S, Shum M, Anderson S, Nichols I, Paul K, Liesa M, Ajijola OA, Xu Y, Adhikari A, Correa SM. Estrogen-Sensitive Medial Preoptic Area Neurons Coordinate Torpor in Mice. Nature communications, 2020;11:6378
4. Zhang Z, Machado F, Zhao L, Heinen CA, Foppen E, Ackermans MT, Zhou J, Bisschop PH, Boelen A, Fliers E, Kalsbeek A. Administration of thyrotropin-releasing hormone (TRH) in the hypothalamic paraventricular nucleus (PVN) of male rats mimics the metabolic cold defence response, Neuroendocrinology, 2018;107:267–279
5. Zhang Z, Liu J, Veldhuis-Vlug AG, Su Y, Foppen E, van der Eerden BC, Koedam M, Bravenboer N, Kalsbeek A, Boelen A, Fliers E, Bisschop PH. Effects of chronic estrogen administration in the ventromedial nucleus of the hypothalamus (VMH) on fat and bone metabolism in ovariectomized rats, Endocrinology. 2016; 157(12): 4930-4942
6. Zhang Z, Foppen E, Su Y, Bisschop PH, Kalsbeek A, Fliers E, Boelen A. Metabolic effects of chronic T3 administration in the hypothalamic para-ventricular and ventromedial nucleus in male rats, Endocrinology. 2016; 157(10): 4076-4085
7. Zhang Z, Bisschop PH, Foppen E, van Beeren HC, Kalsbeek A, Boelen A, Fliers E. A model for chronic, intrahypothalamic thyroid hormone administration in rats, Journal of Endocrinology 2016; 229(1):37-45 (Cover story)