洪尚宇

发布时间：2021-06-27浏览次数：5237

教师基本信息：

姓名：洪尚宇（Shangyu Hong）

职称：研究员（Principal Investigator）

电子邮箱：shangyu_hong@fudan.edu.cn

办公地点：复旦大学江湾校区生科院楼D215（Room D215, School of Life Science, Fudan Univeristy）

办公电话：021-31246658


研究方向：

1、研究饮食与营养代谢相关基因的交互作用；

2、研究肝脏和脂肪组织糖脂代谢稳态与代谢性疾病发病机制。

1. The function of critical genes related to nutrients metabolism;

2. The balance of sugar-lipid metabolism and related metabolic diseases.


个人简介：

2001年本科毕业于武汉大学生科院，2007年博士毕业于中科院上海生科院生化细胞所，毕业后于哈佛大学医学院进行博士后研究和工作，2017年进入复旦大学生科院任教。主持多项国家级科研项目。获2018年上海市“浦江人才”，2020年湖北省科技进步三等奖。

In 2001, B.S. from Wuhan University. In 2007, Ph.D. from Shanghai Institute of Biochemistry and Cell Biology. Postdoctoral training in Harvard Medical School. Since 2017, Principal Investigator in Fudan University. In 2018, recruited in “Pujiang Talent Program”. In 2020, awarded the third prize of scientific and technological progress in Hubei Province.


授课情况：

《生物化学》、《科研伦理与规范》

《Biochemistry》、《Bioethics》。


招生专业：生理学与神经生物学系（Physiology and Neurobiology）


科研项目：

  1. 国家自然科学基金委面上项目“肠道菌群在生酮饮食糖脂代谢中的调控作用与分子机制”，2023.01-2026.12，负责人；

  2. 上海市自然科学基金面上项目“生酮饮食通过肠道菌群及特异性胆汁酸改变宿主代谢”，2023.04-2026.03，项目负责人；

  3. 国家科技部重点研发计划“发育编程及其代谢调控”重点专项项目“分泌蛋白对能量稳态的调控和机制”， 2022.01-2026.12，项目骨干；

  4. 国家科技部重点研发计划“发育编程及其代谢调控”重点专项项目“不同发育阶段肠道菌群特征及其对发育的影响”， 2020.01-2024.12，项目骨干；

  5. 国家自然科学基金委面上项目“烟酰胺N-甲基转移酶（Nnmt）在肝脏代谢中的功能和分子机制研究”，2020.01-2023.12，项目负责人；

  6. 国家自然科学基金委重大研究计划-培育项目“Vgll4在糖脂代谢调控中的功能和分子机制研究”，2020.01-2022.12，项目负责人；

  7. 上海市“浦江人才”项目“烟酰胺N-甲基转移酶（Nnmt）在甲硫氨酸循环中的功能与机制研究”，2018.07-2020.06，项目负责人；


代表性论文和论著：

  1. Yilian Liu*, Wanglei Zhong*, Xiao Li*, Feng Shen*, Xiaonan Ma, Qi Yang, Shangyu Hong#, Yan Sun#. Diets, Gut Microbiota and Metabolites. Phenomics2023 Mar 2;3(3):268-284.

  2. Kang Yao*, Yuxiang Dai*, Juan Shen*, Yi Wang*, Huanjie Yang, Runda Wu,Qijun Liao, Hongyi Wu, Xiaodong Fang, Shalaimaiti Shali, Lili Xu, Meng Hao, Chenhao Lin, Zhonghan Sun, Yilian Liu, MengxinLi, Zhen Wang, Qiang Gao, Shuning Zhang, Chenguang Li, Wei Gao, Lei Ge, Yunzeng Zou, Aijun Sun, Juying Qian, Li Jin, Shangyu Hong#, Yan Zheng#, and Junbo Ge#. Exome sequencing identifies rare mutations of LDLR and QTRT1 conferring risk for early-onset coronary artery disease in Chinese. Natl Sci Rev 2022 May 31;9(8).

  3. Chuanyou Yi*, Dandan Li*, Xiao Guo*, Jinhui Wang, Cenxi Liu, Guangxing Lu, He Huang#, Shangyu Hong#, Jin Li#. The storage conditions of high fat diet are the key factors for diet induced obesity and liver damage. Nutrients.2022May 26; 14(11), 2222.

  4. Dandan Li*, Chuanyou Yi*, He Huang, Jin Li# and Shangyu Hong#. Hepatocyte specific depletion of Nnmt protects the mice from non-alcoholic steatohepatitis. J Hepatol. 2022 Mar 30;S0168-8278(22)00191-X.

  5. Zhuang Wei, Jigang Lei, Feng Shen, Yuxiang Dai, Yan Sun, Yilian Liu, Yan Dai, Shilong Wang, Zhengjun Chen#, Kan Liao# and Shangyu Hong#.Cavin1 deficiency causes disorder of hepatic glycogen metabolism and neonatal death by impacting fenestrations in liver sinusoidal endothelial cells. Adv. Sci. 2020 Aug 21;7(19):2000963.

  6. Shanshan Guo, Yiru Huang, Yan Zhang, He Huang, Shangyu Hong# and Tiemin Liu#. Impacts of exercise interventions on different diseases and organ functions in mice. J. Sport Health Sci. 2020 Jan; 9(1): 53-73.

  7. Shangyu Hong#, Bo Zhai, Pavlos Pissios#. Nicotinamide N-Methyltransferase Interacts with Enzymes of the Methionine Cycle and Regulates Methyl Donor Metabolism. Biochemistry. 2018 Oct 9;57(40):5775-5779.

  8. Shangyu Hong, Wei Song, Peter-James H. Zushin, Bingyang Liu, Mark P. Jedrychowski, Amir I. Mina, Zhaoming Deng , Dimitrije Cabarkapa, Jessica A. Hall , Colin J. Palmer, Hassan Aliakbarian,John Szpyt, Steven P. Gygi, Ali Tavakkoli, Lydia Lynch, Norbert Perrimon, Alexander S. Banks. Phosphorylation of Beta-3 adrenergic receptor at serine 247 by ERK MAP kinase drives lipolysis in obese adipocytes. Mol Metab.2018 Jun;12:25-38.

  9. Shangyu Hong, Jose M Moreno-Navarrete, Xiaojing Wei, Yusuke Kikukawa, Iphigenia Tzameli, Deepthi Prasad, Yoonjin Lee, John M Asara, Jose Manuel Fernandez- Real, Eleftheria Maratos-Flier and Pavlos Pissios. Nicotinamide N-methyltransferase regulates hepatic nutrient metabolism through Sirt1 protein stabilization. Nat Med. 2015 Aug;21(8):887-94. Highlight in Cell Metab 2015 Aug 4;22(2):200-1.

  10. Alexander M. Real*, Shangyu Hong* and Pavlos Pissios. Nicotinamide N-Oxidation by CYP2E1 in Human Liver Microsomes. Drug Metab Dispos. 2013 41 (3), 550-553.

  11. Shangyu Hong, Hairong Huo, Jinfei Xu and Kan Liao. Insulin-Like Growth Factor-1 Receptor Signaling in 3T3-L1 Adipocyte Differentiation Requires Lipid Rafts But Not Caveolae. Cell Death Differ. 2004 Jul;11(7):714-23.