洪尚宇

发布者:王诗铭发布时间:2021-06-27浏览次数:338

教师基本信息

姓名:洪尚宇

职称:青年研究员

职务:

电子邮箱:shangyu_hong@fudan.edu.cn

办公地点:复旦大学生命科学学院D215

办公电话:021-51630658


研究方向

1. 研究饮食与营养代谢相关基因的交互作用;

2. 研究肝脏和脂肪组织糖脂代谢稳态与代谢性疾病发病机制。


个人简介

2001年本科毕业于武汉大学生科院,2007年博士毕业于中科院上海生科院生化细胞所,毕业后于哈佛大学医学院进行博士后研究和工作,2017年受聘复旦大学生科院任青年研究员。主持多项国家级科研项目。获2018年上海市“浦江人才”,2020年湖北省科技进步三等奖(本人排名第四)。


授课情况

《生物化学》、《科研伦理与规范》、《书报讨论》。


招生专业

生理学与神经生物学系


代表性论文和论著

  1. Zhuang Wei, Jigang Lei, Feng Shen, Yuxiang Dai, Yan Sun, Yilian Liu, Yan Dai, Shilong Wang, Zhengjun Chen#, Kan Liao# and Shangyu Hong#. Cavin1 deficiency causes disorder of hepatic glycogen metabolism and neonatal death by impacting fenestrations in liver sinusoidal endothelial cells. Adv. Sci. 2020 Aug 21;7(19):2000963. (#通讯作者).

  1. Shanshan Guo, Yiru Huang, Yan Zhang, He Huang, Shangyu Hong# and Tiemin Liu#. Impacts of exercise interventions on different diseases and organ functions in mice. J. Sport Health Sci. 2020 Jan; 9(1): 53-73. (#通讯作者).

  2. Shangyu Hong#, Bo Zhai, Pavlos Pissios#. Nicotinamide N-Methyltransferase Interacts with Enzymes of the Methionine Cycle and Regulates Methyl Donor Metabolism. Biochemistry. 2018 Oct 9;57(40):5775-5779. (#通讯作者).

  3. Shangyu Hong, Wei Song, Peter-James H. Zushin, Bingyang Liu, Mark P. Jedrychowski, Amir I. Mina, Zhaoming Deng , Dimitrije Cabarkapa, Jessica A. Hall , Colin J. Palmer, Hassan Aliakbarian,John Szpyt, Steven P. Gygi, Ali Tavakkoli, Lydia Lynch, Norbert Perrimon, Alexander S. Banks. Phosphorylation of Beta-3 adrenergic receptor at serine 247 by ERK MAP kinase drives lipolysis in obese adipocytes. Mol Metab. 2018 Jun;12:25-38.

  4. Shangyu Hong, Jose M Moreno-Navarrete, Xiaojing Wei, Yusuke Kikukawa, Iphigenia Tzameli, Deepthi Prasad, Yoonjin Lee, John M Asara, Jose Manuel Fernandez- Real, Eleftheria Maratos-Flier and Pavlos Pissios. Nicotinamide N-methyltransferase regulates hepatic nutrient metabolism through Sirt1 protein stabilization. Nat Med. 2015 Aug;21(8):887-94.

  5. Alexander M. Real*, Shangyu Hong* and Pavlos Pissios. Nicotinamide N-Oxidation by CYP2E1 in Human Liver Microsomes. Drug Metab Dispos. 2013 41 (3), 550-553 (*第一作者).

  1. Shangyu Hong, Hairong Huo, Jinfei Xu and Kan Liao. Insulin-Like Growth Factor-1 Receptor Signaling in 3T3-L1 Adipocyte Differentiation Requires Lipid Rafts But Not Caveolae. Cell Death Differ. 2004 Jul;11(7):714-23.