付玉华

发布者:彭筱葳发布时间:2021-06-27浏览次数:585

教师基本信息

姓名:付玉华

职称:青年副研究员

电子邮箱:fuyuhua@fudan.edu.cn

办公地点:复旦大学江湾校区生科楼C221

办公电话:15721283660


个人简介

男,博士,青年副研究员,硕士生导师。2015年博士毕业于复旦大学生物医学研究院(导师:文波),同年于复旦大学脑科学研究院进行博士后训练(合作导师:鲁伯埙),201712月起任复旦大学生命科学院青年副研究员。


研究方向

从事自噬与聚谷氨酰胺(PolyQ)疾病的研究:

1)细胞自噬机制和功能研究;

2)聚谷氨酰胺(PolyQ)疾病致病机制与治疗研究。


科研项目

主持国家自然科学基金面上项目(2019),做为骨干参与国家重大研究计划集成项目(2020)、国家重点研发计划(2021)和上海市科委重大项目(2020)。


获奖情况

长三角神经科学青年科学家奖,2020



招生专业

神经科学

表性论文和论著

(1) Yuhua Fu, Ningxie Chen , Ziying Wang , Shouqing Luo , Yu Ding , Boxun Lu. Degradation of lipid droplets by chimeric autophagy-tethering compounds. Cell Research, 2021 Sep;31(9): 965 -979.(封面论文.

(2) Xiaodan Zhang, Xue Wen, Ismael Al-Ramahi, Juan Botas, Boxun Lu. Yuhua Fu *. Inhibition of HIPK3 by AST487 ameliorates mutant HTT induced neurotoxicity and apoptosis via enhanced autophagy. Neuroscience Bulletin,2021 Nov 5.

(3) Xiao-jing Li#; Yuan-yuan Zhang#; Yu-hua Fu#; Hao Zhang; He-xuan Li;Quan-fu Li; Hai-ling Li; Ren-ke Tan; Chen-xiao Jiang; Wei Jiang; Zeng-xia Li;Cheng Luo; Bo-xun Lu; Yong-jun Dang; Gossypol, a novel modulator of VCP, induces autophagic degradation of mutant huntingtin by promoting the formation of VCP/p97-LC3-mHTT complex, Acta Pharmacologica Sinica, 2021, 42(1): 1-11. #co-first author.

(4) Yuhua Fu#; Peng Wu#; Yuyin Pan#; Xiaoli Sun#; Huiya Yang; Marian Difiglia; Boxun Lu; A toxic mutant huntingtin species is resistant to selective autophagy, Nature Chemical Biology, 2017, 13(11): 1152-1154. #co-first author.

(5) Meng Yu#; Yuhua Fu#; Yijiang Liang#; Haikun Song; Yao Yao; Peng Wu;Yuwei Yao; Yuyin Pan; Lixiang Ma; Saiyin Hexige; Yu Ding; Shouqing Luo; Boxun Lu; Suppression of MAPK11 or HIPK3 reduces mutant Huntingtin levels in Huntington's disease models, Cell Research, 2017, 27(12): 1441-1665.#co-first author.

(6) Yuhua Fu; Pin Lv; Guoquan Yan; Hui Fan; Lu Cheng; Feng Zhang; Yongjun Dang; Hao Wu; Bo Wen; MacroH2A1 associates with nuclear lamina and maintains chromatin architecture in mouse liver cells, Scientific Reports, 2015, 15(5):1-12.




Personal Information

NameYuhua FU

PositionYoung associated professor

Mailfuyuhua@fudan.edu.cn

Office locationC221 of Life Science Building, Jiangwan Campus, Fudan University

Phone15721283660

  

Personal profile: (education work experience, academic part-time job, research projects, awards, etc.)

Male, Doctor, Young associated professor, Master mentor. Dr FU received Ph.D. degrees from the Biomedical Institute of Fudan University in 2015Training mentor: Bo Wen. In the same year, he received postdoctoral training in the Institute of brain science of Fudan UniversityTraining mentor: Boxun Lu, and he has joined the school of life sciences of Fudan University as a young associated professor in since December 2017.

Research interest:

Autophagy and polyglutamine (polyQ) diseases

(1) The mechanism and function of autophagy;

(2) Polyglutamine (polyQ) disease pathogenesis and treatment.

Research projects: Preside over NSFC and participate in the national major research plan integration projects2020)、national key R & D plan (2021) and major projects of Shanghai Science and Technology Commission (2020).

  

Honors & Awards:

Yangtze River Delta neuroscience Young Scientist Award, 2020

  

Major: Neuroscience

  

Representative papers and works:

(1) Yuhua Fu, Ningxie Chen , Ziying Wang , Shouqing Luo , Yu Ding , Boxun Lu. Degradation of lipid droplets by chimeric autophagy-tethering compounds. Cell Research, 2021 Sep;31(9): 965 -979.(封面论文.

(2) Xiaodan Zhang, Xue Wen, Ismael Al-Ramahi, Juan Botas, Boxun Lu. Yuhua Fu *. Inhibition of HIPK3 by AST487 ameliorates mutant HTT induced neurotoxicity and apoptosis via enhanced autophagy. Neuroscience Bulletin,2021 Nov 5.

(3) Xiao-jing Li#; Yuan-yuan Zhang#; Yu-hua Fu#; Hao Zhang; He-xuan Li;Quan-fu Li; Hai-ling Li; Ren-ke Tan; Chen-xiao Jiang; Wei Jiang; Zeng-xia Li;Cheng Luo; Bo-xun Lu; Yong-jun Dang; Gossypol, a novel modulator of VCP, induces autophagic degradation of mutant huntingtin by promoting the formation of VCP/p97-LC3-mHTT complex, Acta Pharmacologica Sinica, 2021, 42(1): 1-11. #co-first author.

(4) Yuhua Fu#; Peng Wu#; Yuyin Pan#; Xiaoli Sun#; Huiya Yang; Marian Difiglia; Boxun Lu; A toxic mutant huntingtin species is resistant to selective autophagy, Nature Chemical Biology, 2017, 13(11): 1152-1154. #co-first author.

(5) Meng Yu#; Yuhua Fu#; Yijiang Liang#; Haikun Song; Yao Yao; Peng Wu;Yuwei Yao; Yuyin Pan; Lixiang Ma; Saiyin Hexige; Yu Ding; Shouqing Luo; Boxun Lu; Suppression of MAPK11 or HIPK3 reduces mutant Huntingtin levels in Huntington's disease models, Cell Research, 2017, 27(12): 1441-1665.#co-first author.

(6) Yuhua Fu; Pin Lv; Guoquan Yan; Hui Fan; Lu Cheng; Feng Zhang; Yongjun Dang; Hao Wu; Bo Wen; MacroH2A1 associates with nuclear lamina and maintains chromatin architecture in mouse liver cells, Scientific Reports, 2015, 15(5):1-12.