教师基本信息：
姓名：丁澦（Yu DING）
职称：教授（Professor）
职务：分党委副书记（Deputy Secretary of the Party Committee）
电子邮箱：yuding@fudan.edu.cn
办公地点：生命科学学院E301-7（E301-7, School of Life Sciences）
办公电话：021-31246726
研究方向：
基于自噬-溶酶体的致病生物大分子靶向降解技术（ATTEC），纳米抗体技术
Autophagy-Lysosome-Based Pathogenic Macromolecular Targeted Degradation Technology (ATTEC), Nanobody Technology
个人简介：
男，1978年4月出生，教授，博士生导师，入选上海市东方英才计划拔尖项目。1996-1999年就读于复旦大学生命科学学院理科基地班，获学士学位；1999年-2004年就读于复旦大学生命科学学院生物物理学专业（硕博连读），获理学博士学位。2004年认定为讲师，2007年晋升副教授，2020年晋升教授，其中2009年2月至2011年9月至香港大学化学系交流。现主持包括国家自然科学基金重点项目和国家重点研发计划（课题组长）在内的多项国家及省部级基金项目。
Male, born in April 1978, Professor, Ph.D. supervisor, selected for the Shanghai Eastern Scholar Program. Yu DING attended the Science Base Class at the School of Life Sciences, Fudan University, from 1996 to 1999, obtaining a bachelor's degree. From 1999 to 2004, he pursued Biophysics at the School of Life Sciences, Fudan University (integrated master's and doctoral program), earning a Ph.D. degree. He was appointed as a lecturer in 2004, promoted to associate professor in 2007, and to professor in 2020. From February 2009 to September 2011, he had an exchange program at the Department of Chemistry, the University of Hong Kong. He currently leads several national and provincial-level projects, including the National Natural Science Foundation Key Project and the National Key R&D Program (as project leader).
授课情况：
本科生《生理学》、《生物技术产业与大学生生涯发展》
研究生《细胞分子生物学》、《现代生物学研究技术》
Undergraduate courses: "Physiology", "Biotechnology Career Development"
Graduate courses: "Molecular Biology of the cell", "Modern Biological Research Techniques"
招生专业：生理与神经（Physiology and Neurology）
科研项目：
2021-2026，国家重点研发计划（课题组长），遗传性共济失调相关运动障碍疾病的遗传基础与发病机制研究，2021YFA0805200
2021-2025，国家自然科学基金，重点项目，自噬小体绑定化合物（ATTEC）与LC3及polyQ致病蛋白相互作用的分子机理，82030106
2021-2024，国家自然科学基金，面上项目，特异抑制G蛋白偶联受体GPR52的全合成人源化纳米抗体的鉴定及验证，32070939
2021-2026, National Key R&D Program (Project Leader), Study on the Genetic Basis and Pathogenic Mechanisms of Hereditary Ataxia-Related Movement Disorders, Project ID: 2021YFA0805200
2021-2025, National Natural Science Foundation of China, Key Project, Molecular Mechanism of Interaction between Autophagosome-Binding Compound (ATTEC) and LC3 as well as PolyQ Pathogenic Proteins, Project ID: 82030106
2021-2024, National Natural Science Foundation of China, General Project, Identification and Validation of Fully Synthetic Humanized Nanobodies Specific for Inhibiting G Protein-Coupled Receptor GPR52, Project ID: 32070939
获奖情况：
Sanofi-Cell Research年度杰出论文奖，“钟扬式”好老师（十佳教师）、本专科生“我心目中的好老师”、指导本科生陈闻涛，陆致晟和吴旭冬获第11届“挑战杯”全国特等奖并获优秀指导教师奖
Sanofi-Cell Research Outstanding Paper Award (2021)
"Zhong Yang-style" Excellent Teacher (Top 10 Teachers), Good Teacher in the Hearts of Undergraduate and Graduate Students
Mentored undergraduates Chen Wentao, Lu Zhisheng, and Wu Xudong, winners of the National Challenge Cup Special Prize at the 11th Challenge Cup, and received the Excellent Mentor Award
代表性论文和论著：
1. Allele-selective lowering of mutant HTT protein by HTT–LC3 linker compounds, Z Li, C Wang, Z Wang, C Zhu, J Li, T Sha, L Ma, C Gao…, Y Ding#, Y Fei#, B Lu#, Nature, 575(7781): 203, (2019) (入选Nature评选的2019年度十大杰出论文)
2. Emerging degrader technologies engaging lysosomal pathways, Y Ding#, D Xing#, Y Fei#, B Lu# - Chemical Society Reviews, 51:8832, (2022) (封面论文，长篇综述)
3. Degradation of lipid droplets by chimeric autophagy-tethering compounds, Y Fu, N Chen, Z Wang, S Luo, Y Ding#, B Lu#, Cell research, 31(9): 965, (2021) (封面论文，获Sanofi-Cell Research 2021年度杰出论文奖)
4. Structural Insights into the Binding of Red Fluorescent Protein mCherry-Specific Nanobodies, H Liang, Z Ma, Z Wang, P Zhong, R Li, H Jiang, X Zong…, R Liu#, Y Ding#, International Journal of Molecular Sciences, 24(8): 6952, (2023)
5. A highly stable human single-domain antibody-drug conjugate exhibits superior penetration and treatment of solid tumors, Y Wu#, Q Li, Y Kong, Z Wang, C Lei, J Li, L Ding…, Y Ding#, T Ying#, Molecular Therapy, 30(8): 2785, (2022)
6. Suppression of toxicity of the mutant huntingtin protein by its interacting compound, desonide, H Song, C Wang, C Zhu, Z Wang, H Yang, P Wu, X Cui…, Y Ding#, Y Fei#, B Lu#, Proceedings of the National Academy of Sciences, 119(10): e2114303119, (2022)
7. Structural insights into the binding of nanobodies LaM2 and LaM4 to the red fluorescent protein mCherry, Z Wang, L Li, R Hu, P Zhong, Y Zhang, S Cheng…, Y Ding#, Protein Science, 30(11): 2298, (2021)
8. Emerging new concepts of degrader technologies, Y Ding#, Y Fei#, B Lu#, Trends in Pharmacological Sciences, 41(7):464, (2020)
9. Targeting the N terminus of eIF4AI for inhibition of its catalytic recycling, C Jiang, Y Tang, L Ding, R Tan, X Li, J Lu, J Jiang…, Y Ding#, J Liu#, Y Dang#, Cell chemical biology, 26(10):1417, (2019)
10. Flotillin-1 downregulates K+ current by directly coupling with Kv2. 1 subunit, R Liu, G Yang, MH Zhou, Y He, YA Mei#, Y Ding#, Protein & Cell, 7(6): 455, (2016)