教师基本信息：
姓名：丁澦
职称：教授
职务：副院长
电子邮箱：yuding@fudan.edu.cn
办公地点：复旦大学生命科学学院E301-7室
办公电话：+86-21-31246726
Title: Professor
Position: Associate Dean
Email: yuding@fudan.edu.cn
Office Location: Room E301-7, School of Life Sciences, Fudan University
Office Phone: +86-21-31246726
个人简介
男，1978年出生，博士，教授，博士生导师。1996-1999年就读于复旦大学生命科学学院理科基地班，获学士学位；1999年-2004年就读于复旦大学生命科学学院生理学和生物物理学系生物物理学专业（硕博连读），获理学博士学位。2004年认定为讲师，2007年晋升副教授，2020年晋升教授，其中2009年2月至2011年9月交流至香港大学化学系。现主持包括国家自然科学基金重点项目和国家重点研发计划（课题组长）在内的多项国家及省部级基金项目。
Male, born in 1978, Ph.D., Professor, and Doctoral Supervisor.
From 1996 to 1999, Yu Ding studied in the National Science Base Class at the School of Life Sciences, Fudan University, where he obtained his Bachelor's degree. From 1999 to 2004, he completed a continuous Master's-Doctoral program in Biophysics within the Department of Physiology and Biophysics at the School of Life Sciences, Fudan University, earning a Ph.D. in Science.
Yu Ding was appointed as a Lecturer in 2004, promoted to Associate Professor in 2007, and promoted to Professor in 2020. During this time, he was a visiting scholar at the Department of Chemistry, The University of Hong Kong from February 2009 to September 2011.
He is currently leading several national, provincial, and ministerial research funds, including a Key Program of the National Natural Science Foundation of China (NSFC) and a National Key R&D Program of China (as a Research Group Leader).
授课情况：
本科生《生理学》、《生物技术产业与大学生生涯发展》
研究生《细胞分子生物学》、《现代生物学研究技术》
Undergraduate courses: Physiology, Biotechnology Career Development
Graduate courses: Molecular Biology of the Cell, Modern Biological Research Techniques
招生专业：生理与神经
Admissions Major: Physiology and Neurology
研究方向
靶向降解技术的分子机制
纳米抗体的高通量筛选、验证和应用
Research Interests
Molecular Mechanisms of Targeted Protein Degradation Technologies
High-Throughput Screening, Validation, and Application of Nanobodies
获奖情况
Sanofi-Cell Research年度杰出论文奖，“钟扬式”好老师（十佳教师）、本专科生“我心目中的好老师”、指导本科生陈闻涛，陆致晟和吴旭冬获第11届“挑战杯”全国特等奖并获优秀指导教师奖
Awards and Honors
Sanofi-Cell Research Outstanding Paper of the Year Award
Zhong Yang-style Good Teacher Award (Top 10 Faculty Members)
My Favorite Teacher Award (voted by undergraduate and junior college students)
Excellent Advisor Award (for guiding undergraduates Wentao Chen, Zhisheng Lu, and Xudong Wu to the National Special Prize at the 11th Challenge Cup)
主持的主要科研项目
2025-2028，国家自然科学基金，面上项目
2021-2025，国家自然科学基金，重点项目
2021-2024，国家自然科学基金，面上项目
2021-2026，国家重点研发计划（课题组长）
Major Research Projects (As Principal Investigator)
2025–2028: General Program, National Natural Science Foundation of China (NSFC)
2021–2025: Key Program, National Natural Science Foundation of China (NSFC)
2021–2024: General Program, National Natural Science Foundation of China (NSFC)
2021–2026: National Key R&D Program of China (as Research Group Leader)
代表性论文和论著
Representative Publications
Z Li, C Wang, Z Wang, C Zhu, J Li, T Sha, L Ma, C Gao, ..., Y Ding#, Y Fei#, B Lu#, Allele-selective lowering of mutant HTT protein by HTT–LC3 linker compounds, Nature, 575(7781): 203, (2019) (入选Nature评选的年度十大杰出论文)
Y Ding, B Lu#, SnapShot: targeted protein degradation, Cell, 187(23): 6784-6784.e1, (2024)
Y Ding#, D Xing#, Y Fei#, B Lu#, Emerging degrader technologies engaging lysosomal pathways, Chemical Society Reviews, 51: 8832, (2022) (封面论文，长篇综述)
Y Fu, N Chen, Z Wang, S Luo, Y Ding#, B Lu#, Degradation of lipid droplets by chimeric autophagy-tethering compounds, Cell Research, 31(9): 965, (2021) (封面论文，获Sanofi-Cell Research年度杰出论文奖)
Y Luo, J Zhang, Z Dong, Y Ding#, Anticalins: A viable alternative to nanobodies? –from discovery to AI-driven development: A review, International Journal of Biological Macromolecules, 151623, (2026)
P Zhong, B Chu, Z Yu, Y Qiao, Y Ding#, Y Zhang#, X Wu#, Molecular basis of antagonism of the dimeric human arginine vasopressin receptor 1A, Nature Communications, 17(1): 1622, (2026)
S Cheng, C Zhong, H Zhu, K Mu, H Jiang, P Zhong, Z Ma, X Liu, Z Wang, R Liu#, Y Ding#, Structural mechanisms and insights on multiple nanobodies binding diverse SOD1 epitopes, Communications Biology, 9(1): 30, (2025)
C Zhong, X Gao, Q Chen, B Guan, W Wu, Z Ma, M Tao, X Liu, Y Ding#, Y Fei#, Y Liu#, B Lu#, Z Li#, R406 and its structural analogs reduce SNCA/α-synuclein levels via autophagic degradation, Autophagy, 21(9): 1945-1961, (2025)
H Zhu, Y Ding#, Nanobodies: from discovery to AI-driven design, Biology, 14(5): 547, (2025)
C Gao, L Yao, X Liu, Z Wang, R Hu, J Ding, Y Ding#, G Chen#, Hydrogel-to-Nanoparticle Transition with Immune Cell Activation Controlled by Dual Supramolecular Interactions, ACS Applied Materials & Interfaces, 16(49): 67458-67467, (2024)
M Zhu, L Ma, P Zhong, J Huang, J Gai, G Li, Y Li, P Qiao, H Gu, X Li, Y Yin, L Zhang, Z Deng, B Sun, Z Chen#, Y Ding#, Y Wan#, A novel inhalable nanobody targeting IL-4Rα for the treatment of asthma, Journal of Allergy and Clinical Immunology, 154(4): 1008-1021, (2024)
X Zong, P Liu, Z Wang, H Zhu, C Zhong, P Zhong, H Jiang, J Liu, Z Ma, R Liu#, Y Ding#, Structural insights into the binding of nanobodies to the Staphylococcal enterotoxin B, International Journal of Biological Macromolecules, 276: 133957, (2024)
Z Li#, Z Wang, C Zhong, H Zhang, R Liu, P An, Z Ma, J Lu, C Pan, Z Zhang, Y Fei#, Y Ding#, B Lu#, P53 upregulation by USP7-engaging molecular glues, Science Bulletin, 69(12): 1936-1953, (2024)
Y Ding#, D Xing#, Y Fei#, S Luo, B Lu#, Perspectives of autophagy-tethering compounds (ATTECs) in drug discovery, Medicine Plus, 1(1): 100004, (2024)
H Liang, Z Ma, Z Wang, P Zhong, R Li, H Jiang, X Zong, C Zhong, X Liu, P Liu, J Liu, H Zhu, R Liu#, Y Ding#, Structural insights into the binding of red fluorescent protein mCherry-specific nanobodies, International Journal of Molecular Sciences, 24(8): 6952, (2023)
H Song, C Wang, C Zhu, Z Wang, H Yang, P Wu, X Cui, J Botas, Y Dang, Y Ding#, Y Fei#, B Lu#, Suppression of toxicity of the mutant huntingtin protein by its interacting compound, desonide, Proceedings of the National Academy of Sciences, 119(10): e2114303119, (2022)
Y Wu#, Q Li, Y Kong, Z Wang, C Lei, J Li, L Ding, C Wang, Y Cheng, Y Wei, Y Song, Z Yang, C Tu, Y Ding#, T Ying#, A highly stable human single-domain antibody-drug conjugate exhibits superior penetration and treatment of solid tumors, Molecular Therapy, 30(8): 2785-2799, (2022)
Z Wang, L Li, R Hu, P Zhong, Y Zhang, S Cheng, H Jiang, R Liu, Y Ding#, Structural insights into the binding of nanobodies LaM2 and LaM4 to the red fluorescent protein mCherry, Protein Science, 30(11): 2298-2309, (2021)
Y Ding#, Y Fei#, B Lu#, Emerging new concepts of degrader technologies, Trends in Pharmacological Sciences, 41(7): 464-474, (2020)
C Jiang, Y Tang, L Ding, R Tan, X Li, J Lu, J Jiang, Z Cui, Z Tang, W Li, Z Cao, T Schneider-Poetsch, W Jiang, C Luo, Y Ding#, J Liu#, Y Dang#, Targeting the N terminus of eIF4AI for inhibition of its catalytic recycling, Cell Chemical Biology, 26(10): 1417-1426.e5, (2019)