王纲

发布者:王诗铭发布时间:2021-06-27浏览次数:444

教师基本信息

职称:正高级

职务:特聘教授,副院长

电子邮箱:gwang_fd@fudan.edu.cn

办公地点:复旦大学生命科学学院E201

办公电话:021-31246766

个人网页/课题组主页:


个人简介

王纲,复旦大学生命科学学院特聘教授,长期研究发育与疾病的转录及表观遗传调控;作为通讯作者在Mol CellDev CellGenes DevEMBO JPNASNature CommPloS Biol等杂志发表论文。多项工作作为Mol CellEMBO J等重要学术期刊的封面文章发表,获同期专评,以及Faculty1000, Nature Asia-AIMBN, BioArt,“知识分子”的亮点评论。现任JBC等学术期刊编委,获“国务院特殊津贴”、“百人计划”及“上海浦江人才计划”,先后担任国家重大科学研究计划及重点研发计划首席科学家


研究方向

本实验室长期专注于转录中介体的分子调控机理及其在发育(成体干细胞分化等)和疾病(代谢疾病、神经相关疾病、癌症等)中的功能研究。发现MediatormRNA剪切加工、转录延伸、以及DNA损伤修复过程中的非经典功能;首次提出平滑肌与脂肪细胞的“双向调控”及其共同起源;发现Mediator不同亚基在胚胎干细胞干性维持及多谱系细胞分化中的不同功能;发现转录中介体亚基MED23参与调控间充质干细胞向成骨细胞分化过程并影响成骨的发育;揭示Mediator作为表观遗传调控因子,调控癌症与肌肉细胞分化之间的拮抗作用;


授课情况

《现代生物学基础与前沿ll-遗传与发育生物学》(研究生);《干细胞与发育》(本科)


招生专业

生物化学;细胞与发育生物学


代表性论文:

  1. Yenan Yang, Xiaoli Zhu, Xiang Jia, Wanwan Hou, Guoqiang Zhou, Zhangjing Ma, Bin Yu, Yan Pi, Xumin Zhang, Jingqiang Wang, and Gang Wang*. Phosphorylation of Msx1 promotes cell proliferation through the Fgf9/18-MAPK signaling pathway during embryonic limb development. Nucleic Acids Research 2020; Online

  2. Zhichao Wang#, Dan Cao#, Chonghui Li, Lihua Min, Gang Wang* Mediator MED23 regulates inflammatory responses and liver fibrosis. PLoS Biology 2019;17(12): e3000563.

  3. Min Xia, Kun Chen,Xiao Yao, Yichi Xu,Jiaying Yao, Jun Yan, ZhenShao, andGang Wang*. Mediator subunit MED23 links pigmentation and DNA repair through the transcription factor MITF. Cell Reports2017; 20(8):1794-1804.Highlighted in Intellectuals, & BioART.

  4. Zhen Liu, Xiao Yao, Guang Yan, Yichi Xu, Jun Yan, Weiguo Zou*, Gang Wang*. Mediator MED23 cooperates with RUNX2 to drive osteoblast differentiation and bone development. Nat Commun. 2016; 7:11149.

  5. Xiao Yao, Zhanyun Tang, Jingwen Yin, Yan Liang, Xing Fu, Robert G. Roeder,Gang Wang*. The Mediator subunit MED23 couples H2B mono-ubiquitination to transcriptional control and cell fate determination. EMBO J. 2015; 34(23):2885-902. (Cover story with commentary)

  6. Jingwen Yin, and Gang Wang*. The Mediator complex: a master coordinator of transcription and cell lineage development. Development 2014; 141:977-987. (Invited review)

  7. Yajing Chu, Leonardo Gomez Rosso, Ping Huang, Zhichao Wang, Yichi Xu, Xiao Yao, Menghan Bao, Jun Yan, Haiyun Song, Gang Wang*. Liver Med23 ablation improves glucose and lipid metabolism through modulating FOXO1 activity. Cell Res. 2014; 24:1250-1265.

  8. Jingwen Yin, Yan Liang, JiYeon Park, Dongrui Chen, Xiao Yao, Qi Xiao, Zhen Liu, Bo Jiang, Yu Fu, Menghan Bao, Yan Huang, Yuting Liu, Jun Yan, Minsheng Zhu, Zhongzhou Yang, Pingjin Gao, Bin Tian, Dangsheng Li, GangWang*. The Mediator MED23 plays opposing roles in directing smooth muscle cell and adipocyte differentiation. Genes & Dev. 2012; 26(19):2192-2205. (Highlighted by Nature Asia – AIMBN)

  9. Xu Yang, Meng Zhao, Min Xia, Yuting Liu, Jun Yan, HongbinJi, and Gang Wang*. Selective Requirement for Mediator MED23 in Ras-active Lung Cancer. PNAS 2012; 109(41):E2813-22. (Highlighted by Nature Asia – AIMBN)

  10. Yan Huang, Wencheng Li, Xiao Yao, Qijiang Lin, Jingwen Yin, Yan Liang, Monika Heiner, Bin Tian, Jingyi Hui, and Gang Wang*. Mediator Complex Regulates Alternative mRNA Processing via the MED23 Subunit. Mol Cell 2012; 45:459-469. (Cover story with commentary; Highlighted in Faculty 1000)

  11. Wei Wang, Lu Huang, Yan Huang, Jingwen Yin, Arnold J. Berk, Jeffrey Friedman, Gang Wang*. Mediator MED23 links insulin signaling to the adipogenesis transcription cascade. Dev Cell 2009; 16:764-771.