董爱武

发布者:王诗铭发布时间:2021-06-27浏览次数:604

教师基本信息

姓名:董爱武

职称:教授

职务:

电子邮箱aiwudong@fudan.edu.cn

办公地点:淞沪路2005号,复旦大学江湾校区,生命科学学院A401,上海,200438

办公电话:021-31246633


研究方向

植物表观遗传学

利用生物化学、遗传学、结构生物学、生物信息学等方法研究植物生长发育和环境适应过程中的表观遗传调控机制。主要包括(1)染色质组装与重塑调控植物细胞命运和生长发育的分子机制,(2)组蛋白甲基化修饰及其识别调节植物生长发育及环境适应的分子机制。


个人简介

1989-1993,吉林大学,获得生物化学学士学位;1993-1996,北京大学,获得生物化学硕士学位;2000-2003,复旦大学,获得生物化学博士学位。1996年起,复旦大学生命科学学院任教,历任助教、讲师、副教授、教授,现任复旦大学生物化学系主任。工作以来,主持多项国家自然科学基金面上、重点、重大研究计划等科研项目。2013年起担任法国国家科学研究中心植物表观遗传学国际联合实验室中方主任。曾获教育部优秀青年教师(2003年)、上海市科技启明星(2003年)、上海市曙光学者(2008年)等称号,2007年获得中国青年女科学家奖。


授课情况

生物化学-荣誉课程,表观遗传学-荣誉课程


招生专业

生物化学(表观遗传方向)


代表性论文和论著(*通讯作者)

1. Chen K, Du K, Shi Y, Yin L, Shen WH, Yu Y, Liu B*, Dong A*. (2021) H3K36 methyltransferase SDG708 enhances drought tolerance by promoting abscisic acid biosynthesis in rice.  New Phytol. doi: 10.1111/nph.17290

2. Luo Q, Wang B, Wu Z, Jiang W, Wang Y, Du K, Zhou N, Zheng L, Gan J, Shen WH, Ma J*, Dong A*. (2020) NAP1-Related Protein 1 (NRP1) has multiple interaction modes for chaperoning histones H2A-H2B. Proc Natl Acad Sci U S A. 117(48):30391-30399. doi: 10.1073/pnas.2011089117

3. Du K, Luo Q, Yin L, Wu J, Liu Y, Gan J, Dong A*, Shen WH*. (2020) OsChz1 acts as a histone chaperone in modulating chromatin organization and genome function in rice. Nat Commun. 11(1):5717. doi: 10.1038/s41467-020-19586-z

  4. An Z, Yin L, Liu Y, Peng M, Shen WH*, Dong A*. (2020) The histone methylation readers MRG1/MRG2 and the histone chaperones NRP1/NRP2 associate in fine-tuning Arabidopsis flowering time. Plant J. 103(3):1010-1024. doi: 10.1111/tpj.14780

5. Wang B, Luo Q, Li Y, Yin L, Zhou N, Li X, Gan J*, Dong A*. (2020) Structural insights into target DNA recognition by R2R3-MYB transcription factors. Nucleic Acids Res. 48(1):460-471. doi: 10.1093/nar/gkz1081 

6. Liu B, Liu Y, Wang B, Luo Q, Shi J, Gan J, Shen W-H, Yu Y*, Dong A*. (2019) The transcription factor OsSUF4 interacts with SDG725 in promoting H3K36me3 establishment. Nat Commun. 10(1):2999. doi: 10.1038/s41467-019-10850-5 

7. Liu Y, Liu K, Yin L, Yu Y, Qi J, Shen WH, Zhu J, Zhang Y*, Dong A*. (2019) H3K4me2 functions as a repressive epigenetic mark in plants. Epigenetics Chromatin. 12(1):40. doi: 10.1186/s13072-019-0285-6 

8. Jiang W, Li Z, Yao X, Zheng B, Shen WH, Dong A*. (2018) jaw-1D: a gain-of-function mutation responsive to paramutation-like induction of epigenetic silencing. J Exp Bot. 70(2):459-468. doi: 10.1093/jxb/ery365 

9. Wei G, Liu K, Shen T, Shi J, Liu B, Han M, Peng M, Fu H, Song Y, Zhu J*, Dong A*, Ni T*. (2018) Position-specific intron retention is mediated by the histone methyltransferase SDG725. BMC Biol. 16(1):44. doi: 10.1186/s12915-018-0513-8 

10. Li C, Liu Y, Shen WH, Yu Y*, Dong A*. (2018) Chromatin-remodeling factor OsINO80 is involved in regulation of gibberellin biosynthesis and is crucial for rice plant growth and development. J Integr Plant Biol. 60(2):144-159. doi: 10.1111/jipb.12603

11. Liu K, Yu Y, Dong A*, Shen WH*. (2017) SET DOMAIN GROUP701 encodes a H3K4-methytransferase and regulates multiple key processes of rice plant development. New Phytol. 215(2):609-623. doi: 10.1111/nph.14596 

12. Zhu Y*, Rong L, Luo Q, Wang B, Zhou N, Yang Y, Zhang C, Feng H, Zheng L, Shen WH, Ma J*, Dong A*. (2017) The Histone Chaperone NRP1 Interacts With WEREWOLF to Activate GLABRA2 in Arabidopsis Root Hair Development. Plant Cell. 29(2):260-276. doi: 10.1105/tpc.16.00719

13. Zhou W, Gao J, Ma J, Cao L, Zhang C, Zhu Y, Dong A*, Shen WH*. (2016) Distinct roles of the histone chaperones NAP1 and NRP and the chromatin-remodeling factor INO80 in somatic homologous recombination in Arabidopsis thaliana. Plant J. 88(3):397-410. doi: 10.1111/tpj.13256 

14. Liu B, Wei G, Shi J, Jin J, Shen T, Ni T, Shen WH, Yu Y*, Dong A*. (2016) SET DOMAIN GROUP 708, a histone H3 lysine 36-specific methyltransferase, controls flowering time in rice. New Phytol. 210(2):577-88. doi: 10.1111/nph.13768 

15. Jin J, Shi J, Liu B, Liu Y, Huang Y, Yu Y*, Dong A*. (2015) MRG702, a reader protein of H3K4me3 and H3K36me3, is involved in brassinosteroid-regulated growth and flowering time control in rice. Plant Physiol. 168(4):1275-85. doi: 10.1104/pp.114.255737 

16. Zhang C, Cao L, Rong L, An Z, Zhou W, Ma J, Shen WH, Zhu Y*, Dong A*. (2015) The chromatin-remodeling factor AtINO80 plays crucial roles in genome stability maintenance and in plant development. Plant J. 82(4):655-68. doi: 10.1111/tpj.12840

17. Bu Z, Yu Y, Li Z, Liu Y, Jiang W, Huang Y, Dong A*. (2014) Regulation of Arabidopsis flowering by the histone mark readers MRG1/2 via interaction with CONSTANS to modulate FT expression. PLoS Genet. 10(9):e1004617. doi: 10.1371/journal.pgen.1004617 

18. Weng M, Yang Y, Feng H, Pan Z, Shen WH, Zhu Y*, Dong A*. (2014) Histone chaperone ASF1 is involved in gene transcription activation in response to heat stress in Arabidopsis thaliana. Plant Cell Environ. 37(9):2128-38. doi: 10.1111/pce.12299 

19. Sui P, Shi J, Gao X, Shen WH, Dong A*. (2013) H3K36 methylation is involved in promoting rice flowering.Mol Plant. 6(3):975-7. doi: 10.1093/mp/sss152 

20. Li Z, Li B, Shen WH, Huang H, Dong A*. (2012) TCP transcription factors interact with AS2 in the repression of class-I KNOX genes in Arabidopsis thaliana.Plant J. 71(1):99-107. doi: 10.1111/j.1365-313X.2012.04973.x 

21. Sui P, Jin J, Ye S, Mu C, Gao J, Feng H, Shen WH, Yu Y*, Dong A*. (2012) H3K36 methylation is critical for brassinosteroid-regulated plant growth and development in rice.Plant J. 70(2):340-7. doi: 10.1111/j.1365-313X.2011.04873.x 

22. Li Z, Li B, Dong A*. (2012) The Arabidopsis transcription factor AtTCP15 regulates endoreduplication by modulating expression of key cell-cycle genes.Mol Plant. 5(1):270-80. doi: 10.1093/mp/ssr086 

23. Zhu Y, Weng M, Yang Y, Zhang C, Li Z, Shen WH*, Dong A*. (2011) Arabidopsis homologues of the histone chaperone ASF1 are crucial for chromatin replication and cell proliferation in plant development.Plant J. 66(3):443-55. doi: 10.1111/j.1365-313X.2011.04504.x 

24. Liu Z, Gao J, Dong A*, Shen WH*. (2009) A truncated Arabidopsis NUCLEOSOME ASSEMBLY PROTEIN 1, AtNAP1;3T, alters plant growth responses to abscisic acid and salt in the Atnap1;3-2 mutant.Mol Plant. 2(4):688-99. doi: 10.1093/mp/ssp026 

25. Liu Z, Zhu Y, Gao J, Yu F, Dong A*, Shen WH*. (2009) Molecular and reverse genetic characterization of NUCLEOSOME ASSEMBLY PROTEIN1 (NAP1) genes unravels their function in transcription and nucleotide excision repair in Arabidopsis thaliana.Plant J. 59(1):27-38. doi: 10.1111/j.1365-313X.2009.03844.x

26. Zhu Y, Dong A*, Meyer D, Pichon O, Renou JP, Cao K, Shen WH*. (2006) Arabidopsis NRP1 and NRP2 encode histone chaperones and are required for maintaining postembryonic root growth.Plant Cell. 18(11):2879-92

27. Yang L, Liu Z, Lu F, Dong A*, Huang H*. (2006) SERRATE is a novel nuclear regulator in primary microRNA processing in Arabidopsis.Plant J. 47(6):841-50

28. Dong A*, Liu Z, Zhu Y, Yu F, Li Z, Cao K, Shen WH. (2005) Interacting proteins and differences in nuclear transport reveal specific functions for the NAP1 family proteins in plants.Plant Physiol. 138(3):1446-56