教师基本信息：
姓名：王久存
职称：教授
职务：人类遗传学与人类学系系主任
电子邮箱：jcwang@fudan.edu.cn
办公地点：生科楼六楼
研究方向：
硬皮病、强直性脊柱炎等风湿免疫性疾病的遗传学及分子致病机理研究、皮肤表型组学研究及人类高原习服表型组学研究。
建立了多中心研究队列；发现成纤维细胞生长因子6（FGF6）是新的铁代谢调控基因（Blood 2019）；发现低密度脂蛋白受体LDLR缺失可诱发LDL累积并促进肺纤维化发生，LDLR在保护肺组织免受损伤及抗纤维化中发挥重要作用（；发现中国人群存在两种微生物皮肤型，初步解析了中国汉族人群皮肤微生物组特征（Microbiome 2021）；发现高海拔暴露各阶段多器官系统间的纵向协同反应变化规律和个体生理异质性（。
个人简介：
1988及1991年分获复旦大学生物系学士及硕士学位，1999年获日本福井大学生物应用化学专业博士学位。2007-2008年于美国德克萨斯大学休斯顿健康科学中心访问研究。1991-1994年任复旦大学生命科学学院助教、讲师。2000起任复旦大学生命科学学院讲师、副教授、教授。
现任生命科学学院人类遗传学与人类学系系主任，附属华山医院双聘教授，皮肤表型组学研究联合实验室共同主任，复旦大学风湿免疫过敏性疾病研究中心副主任；中国医学科学院皮肤及皮肤病群体遗传学和防控新技术研究创新单元共同主任；上海人类学学会会长，中国遗传学会理事；联合发起硬皮病临床与研究国际协作网（InSCAR）并任副理事长。任Laboratory Investigation、Journal of Scleroderma and Related Disorders等杂志编委。
正在承担国家重点研发计划“发育编程及其代谢调节”重点专项项目（首席科学家）、国家自然科学基金重点项目及区域创新发展联合基金重点项目、上海市市级重大专项子项目、中国医学科学院创新基金等项目。曾作为Site-PI（地区PI）承担NIH-U01项目，主持中国地区硬皮病及强直性脊柱炎HLA区域精细结构分析。发表论文200余篇，近五年来以通讯作者在包括National Science Review、Blood、Annals of The Rheumatic Diseases、Microbiome等在内的高影响力杂志发表论文五十余篇。获教育部科技进步奖一等奖（2022年度，第二完成人）及首届复旦大学刘祖洞人类遗传学奖教金一等奖（2023）等奖励。
授课情况：
生物科学导论、人类表型组学、疾病中的生命科学
招生专业：遗传学、生物信息学、人类生物学
科研项目：
国家重点研发计划“发育编程及其代谢调节”重点专项项目（首席）
国家自然科学基金重点项目
国家自然科学基金区域创新发展联合基金重点项目
上海市市级重大专项子项目
中国医学科学院创新基金
获奖情况：
首届复旦大学刘祖洞人类遗传学奖教金一等奖（2023）
教育部科技进步奖一等奖（2022年度，第二完成人）
2021年度上海市教育系统巾帼文明岗
2019-2020年度复旦大学三八红旗集体
遗传与发育协同创新中心2019年度“十大科技进展”
复旦大学风湿免疫过敏性疾病研究中心首届年度“精英奖”（2012）
代表性论文和论著：
1) Huang Y#, Zhao H#, Zhang Y, Tang Y, Shi X, Jiang S, Pu W, Liu J, Ma Y, Lin J, Lin J, Wu W, Gong Y*, *, Liu Q*. Enhancement of zyxin promotes skin fibrosis by regulating FAK/PI3K/AKT and TGF-β signaling pathways via integrins. . 2023 Apr 29;19(8):2394-2408.
2) Ma Y#, Tan Yimei, Hu Y, Pu W, Xu J, Jin L*, *. Quantitative assessment of ultraviolet-induced erythema and tanning responses in the Han Chinese population, , 2023.
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4) Liu J#, Huang Y#, Gong Y#, Liu Q#, Lin J#, Liu J#, Liu M, Huang J, Pu W, Ma Y, Zhang Y, Li H, Shi X, Zhang Y, Wang J, Zhu Y, Wang Q, Wei K, Wang J, Sha Y, *, Wu W*. CTHRC1+ fibroblasts are stimulated by macrophage-secreted SPP1 to induce excessive collagen deposition in keloids. . 2022 Dec;12(12):e1115.
5) Shi X, Chen Y, Liu Q, Mei X, Liu J, …, Zou H, Zhao S, Distler JHW, Jin L, Wang J*. LDLR dysfunction induces LDL accumulation and promotes pulmonary fibrosis. Clinical and Translational Medicine. 2022 Jan;12(1):e711. doi: 10.1002/ctm2.711. PMID: 35083881.
6) Pu W#, Zhang R#, Ma Y, Liu Q, Jiang S, Liu J, Zhao Y, Tu W, Guo G, Zuo X, Wang Q, Chen Y, Wu W, Zhou X, Distler JHW, Reveille JD, Zou H, Jin L, Mayes MD, Wang J*. Genetic associations of non-major histocompatibility complex susceptibility loci with systemic sclerosis in a Han Chinese population. Journal of Investigative Dermatology2022 Jul;142(7):2039-2042.e7.
7) Pu W#, Wu W#, Liu Q#, Ma Y#, Tu W#, Zuo X#, Guo G#, Jiang S, Zhao Y, Zuo X, Wang Q, Yang L, Xiao R, …, Qi Q, Bai P, Zhao L, Reveille JD, Mayes MD, Jin L, Lee EB, Zhang X, Xu J*, Zhang Z*, Zhou X*, Zou H*, Wang J*. Exome-wide association analysis suggests LRP2BP as a susceptibility gene for endothelial injury in systemic sclerosis in Han Chinese population. Journal of Investigative Dermatology. 2021 May;141(5):1254-1263.e6.
8) Liu J#, Tang Y#, Huang Y#, Gao J, Jiang S, Liu Q, Ma Y, Qian X, Qian F, Reveille JD, He D, Zou H, Jin L, Zhu Q*, Pu W*, Wang J*. Single-cell RNA sequencing deciphers innate immunity in pathogenesis and treatment response of ankylosing spondylitis. Clinical and Translational Medicine. 2021 Mar;11(3):e369.
9) Li Z#, Xia J#, Jiang L#, Tan Y#, An Y, Zhu X, Ruan J, Chen Z, Zhen H, Ma Y, Jie Z, Xiao L, Yang H, Wang J, Kristiansen K, Xu X, Jin L, Nie C*, Krutmann J*, Liu X*, Wang J*. Characterization of the human skin resistome and identification of two microbiota cutotypes. Microbiome. 2021 Feb 17;9(1):47. (Video Byte: https://www.researchsquare.com/article/rs-276355/v1)
10) Sun D#, Niu Z#, Zheng H#, Wu F, Jiang L, Han TQ, Wei Y, Wang J*, Jin L*. A mitochondrial DNA variant elevates the risk of gallstone disease by altering mitochondrial function. Cellular and Molecular Gastroenterology and Hepatology. 2020 Dec 4:S2352-345X(20)30199-5.
11) Liu J#, Pu W#, Li Y, Ma Y, Zhu Q, Wan W, Yang C, Wang X, Chen X, Zhou X, Reveille JD, Jin L, Zou H*, Wang J*. Genetic association of non-MHC region with ankylosing spondylitis in a Chinese population. Annals of the Rheumatic Diseases. 2019 Jun;78(6):852-853.
12) Guo S#, Jiang S#, Epperla N, Ma Y, Maadooliat M, Ye Z, Olson B, Wang M, Kitchner T, Joyce J, An P, Wang F, Strenn R, Mazza JJ, Meece JK, Wu W, Jin L, Smith JA, Wang J* and Schrodi SJ*. A gene-based recessive diplotype exome scan discovers FGF6, a novel hepcidin-regulating iron metabolism gene. Blood. 2019Apr 25;133(17):1888-1898.
13) Ding W#, Pu W#, Jiang S, Ma Y, Liu Q, Wu W, Chu H, Zou H, Jin L, Wang J*, Zhou X*. Evaluation of the antifibrotic potency by knocking down SPARC, CCR2 and SMAD3. EBioMedicine. 2018 Dec;38:238-247.
14) Ding W#, Pu W#, Wang L#, Jiang S, Zhou X, Tu W, Yu L, Zhang J, Guo S, Liu Q, Ma Y, Chen S, Wu W, Reveille J, Zou H, Jin L, Wang J*. Genome-wide DNA methylation analysis in systemic sclerosis reveals hypomethylation of interferon-associated genes in CD4+ and CD8+ T cells. Journal of Investigative Dermatology. 2018 May;138(5):1069-1077.
15) Chu H#, Jiang S#, Liu Q, Ma Y, Zhu X, Liang M, Shi X, Ding W, Zhou X, Zou H, Qian F, Shaul PW, Jin L*, Wang J*. Sirtuin1 protects against systemic sclerosis-related pulmonary fibrosis by decreasing proinflammatory and profibrotic processes. American Journal of Respiratory Cell and Molecular Biology. 2018 Jan;58(1):28-39.
16) Dong Z#, Li Y#, Zhou J, Jiang S, Wang Y, Chen Y, Zhao D, Yang C, Qian Q, Ma Y, He H, Ji H, Yang Y, Wang X, Xu X, Pang Y, Zou H, Jin L, Zhang F*, Wang J*. Copy number variants of ABCF1, IL17REL, and FCGR3A are associated with the risk of gout. Protein & Cell. 2017 Jun;8(6):467-470.
Dr. Jiucun Wang is a professor at the School of Life Sciences and Human Phenome Institute, and adjunct Professor of Huashan Hospital, Fudan University, Shanghai, China. She works on the genetics and molecular mechanism of systemic sclerosis, as well as the skin phenome including skin microbiome. As a Site PI, she led the Chinese effort in one NIH-U01 project entitled “Studies of HLA Region Genomics in Systemic Sclerosis and Ankylosing Spondylitis”. She is leading one National Key R&D Project of the MOST, two major NSFC Projects, and one CAMS Innovation Fund for Medical Science. She has published more than 200 peer-reviewed papers in Blood, Ann Rheum Dis, Natl Sci Rev, Microbiome and other journals. Dr. Wang is currently the Director of Department of Anthropology and Human Genetics, School of Life Sciences, Fudan University, Co-Director of one Innovation Research Unit of CAMS, and Co-Director of the Joint Laboratory of Skin Phenome. She serves as the President of Shanghai Society of Anthropology, and Associate Board Director and Executive Committee Member of the International Network of Scleroderma Clinical Care and Research (InSCAR).