教师基本信息：
职称：副教授Associate Professor
电子邮箱：xhhu@fudan.edu.cn
办公地点：生科院大楼G623 Life Science Building G623
研究方向：
利用分子遗传学、细胞生物学、小鼠动物模型、生物信息学等手段，研究肺癌及脑肿瘤发生发展的分子机制。主要研究方向:（1）基于新一代测序的组学数据，寻找和发掘导致肺癌和脑肿瘤的驱动基因，并致力于揭示其分子机理；（2）解析变异蛋白异常相分离驱动肿瘤发生的机制及筛选相关抗肿瘤小分子药。
We use molecular genetics, cell biology, mouse animal models, bioinformatics and other methods to uncover the molecular mechanics of the occurrence and development of lung cancer and brain tumors. Main research directions: (1) Identify the driver genes that induce lung cancer and brain tumors, and reveal their molecular mechanisms underlying tumorigenesis based on next-generation sequencing omics data; (2) Dissect the mechanism of abnormal phase separation of mutant proteins to drive tumorigenesis and screen related anti-tumor small molecule drugs.
个人简介：
博士，副教授。2006年获复旦大学遗传学博士。2006年-2010年，复旦大学生物医学研究院助理研究员。2011-至今，复旦大学生命学院副教授。2018年-2020年，美国辛辛那提儿童医院医学中心访问科学家。连续多年担任国家基金委青年基金、面上项目的通讯评审专家；教育部研究生论文抽查评审专家、研究生论文校际评审专家。
Ph.D. in Genetics from Fudan University in 2006. Research assistant at the Institutes of Biomedical Sciences, Fudan University from 2006-2010. Associate professor at the School of Life Sciences, Fudan University since 2011. Visiting scientist at Cincinnati Children’s Hospital Medical Center from 2018 to 2020. Communication review expert for the Youth Fund and General Projects of the National Foundation of China; an expert of the Ministry of Education for spot check review of postgraduate thesis and an expert for inter-school review of postgraduate thesis.
通识核心课程“身边的基因科学”和通识课程“生命的科学”
General Core Curriculum “Gene Sciences in Daily Life”and General Curriculum “Sciences of Life”
招生专业：
肿瘤遗传学肿瘤（Tumor Genetics）、生物信息学 (Bioinformatics)、生物与医药 (Biology and medicine)
科研项目：
(1) 基于多层次组学数据遗传分析的肺癌转移和复发分子遗传机制的解析，国家自然科学基金面上项目，2019-01 至 2022-12，57万元，主持
(2) 一种酵母新型RNA转录干扰机制研究，国家自然科学基金面上项目，2016-01 至 2019-12，60万元，主持
(3) 一种新型酵母细胞粘附变异的遗传解析及分子机制，国家自然科学基金面上项目，2013-01 至 2016-12，70万元，主持
(4) 基于新一代测序数据的统计遗传学新理论、方法与应用，国家973计划项目，2012-01 至 2016-08，300万元，子课题负责人
(1) NSFC General Program:
Title: Uncovering the genetic mechanism underlying metastasis and relapse of lung cancer through genetic analysis of multi-level omic sequencing data
Sponsor: National Natural Science Foundation of China
Funding: CNY 570,000.00
Role: Principle Investigator
Period of Protocol: Jan. 2019 – Dec. 2022
(2) NSFC General Program:
Title: Unveiling a novel mechanism underlying transcriptional interference in Saccharomyces cerevisiae
Sponsor: National Natural Science Foundation of China
Funding: CNY 600,000.00
Role: Principle Investigator
Period of Protocol: Jan. 2016 – Dec. 2019
(3) NSFC General Program:
Title: Genetic dissection and molecular mechanisms of a novel type of yeast cell adhesion
Sponsor: National Natural Science Foundation of China
Funding: CNY 700,000.00
Role: Principle Investigator
Period of Protocol: Jan. 2013 – Dec. 2016
(4) Basic Science Research Program of China:
Title: Developing novel theoretical methodology and application based on next-generation sequencing data in statistical genetics (My role: To obtain four high-quality omic-sequencing datasets (RNA-seq, miRNA-seq, methylation-seq and exon-seq) of clinical specimens and cell lines of non-small cell lung cancer)
Funding: CNY 8,360,000.00
Role: Co-PI
Period of Protocol: Jan. 2012 – Aug. 2016
获奖情况：
复星医药奖教金（2016），生命学院优秀教师（2013，2014）
Fosun medical scholarship (2016)，Outstanding teacher of the School of Life Sciences (2013,2014)
代表性论文和论著：
X Hu, X Wu, et al. (2023) Nuclear condensates of YAP fusion proteins alter transcription to drive ependymoma tumorigenesis. Nature Cell Biology, 25:323-336.
Pu W, …, Hu X, et al. (2021) Single-cell transcriptomic analysis of the tumor ecosystems underlying initiation and progression of papillary thyroid carcinoma. Nature Communications 12: 6058.
X Pan*, XH Hu*, et al. (2019). Identification of the copy number variant biomarkers for breast cancer subtypes. Molecular Genetics and Genomics 294 (1), 95-110.
T Liu, X Wu, T Chen, Z Luo, X Hu. (2018). Downregulation of DNMT3A by miR-708-5p inhibits lung cancer stem cell-like phenotypes through repressing Wnt/β-catenin signaling. Clin Cancer Res 24 (7), 1748-1760.
Chen L*, Pan X*, Hu X*, Zhang YH, Wang S, Huang T, Cai YD. (2018). Gene expression differences among different MSI statuses in colorectal cancer. International Journal of Cancer. 143 (7), 1731-1740.
O Fang*, X Hu*, et al. (2018). Amn1 governs post-mitotic cell separation in Saccharomyces cerevisiae. PLoS genetics 14 (10), e1007691.
X Wu, T Liu, O Fang, LJ Leach，X Hu#, Z Luo#. (2014) miR-194 suppresses metastasis of non-small cell lung cancer through regulating expression of BMP1 and p27kip1. Oncogene 33(12):1506-1514.
L Wang, N Jiang, L Wang, O Fang, Lindsey J. Leach, X Hu#, Z Luo#. (2014) 3’ Untranslated Regions Mediate Transcriptional Interference Between Convergent Genes Both Locally and Ectopically in Saccharomyces cerevisiae. PloS Genetics 10(1): e1004021.