姓名：服部素之/ Motoyuki HATTORI
职称：长聘教授/Professor（博士生导师）
电子邮箱：hattorim@fudan.edu.cn
办公地点：上海市杨浦区淞沪路2005号生命科学学院A201
研究方向
离子通道以及转运体的结构与功能，膜蛋白的表达鉴定技术研发，蛋白质从头设计。
个人简介
教育工作经历
2005年获得日本东京大学生物化学学士学位，2009年获得日本东京工业大学生命信息博士学位。2009-2012年在美国俄勒冈健康与科学大学从事博士后研究，2012-2015年在日本东京大学生物化学系任助理研究员及JST研究员。
科研项目
国家自然科学基金面上项目和外青项目、外国优秀青年项目、国际合作交流项目、科技部重点研发计划青年科学家专题等。
授课情况
分子生物学课程，结构生物学课程，现代生物化学和结构生物学训练课程
招生专业
生理和生物物理/Physiology and Biophysics
代表性论文和论著：
1. Guo CR, Sheng D, Li JY, Li TT, Yao JB, Zhang R, Huang Y, Zhao YY, Wang DP, Chen J, Li J, Wang J, Zhou Y, Shen C, Jin F, Cao P, Hattori M*, Liu H*, Yu Y*. Understanding interspecies drug response variations between human and rodent P2X7 receptors. Nat Commun. 2025, 16(1):10827.
2. Jin F, Lin YY, Wang RC, Xie TX, Zhao Y, Shen C, Sheng D, Ichikawa M, Yu Y, Wang J*, Hattori M*. Cryo-EM structure of the zinc-activated channel (ZAC) in the Cys-loop receptor superfamily. Proc Natl Acad Sci U S A. 2024, 121(44):e2405659121.
3. Sumino A, Sumikama T, Zhao Y, Flechsig H, Umeda K, Kodera N, Konno H, Hattori M*, Shibata M*. High-Speed Atomic Force Microscopy Reveals Fluctuations and Dimer Splitting of the N-Terminal Domain of GluA2 Ionotropic Glutamate Receptor-Auxiliary Subunit Complex. ACS Nano. 2024, 18(36):25018-25035.
4. Sheng D, Yue CX, Jin F, Wang Y, Ichikawa M, Yu Y, Guo CR*, Hattori M*. Structural insights into the orthosteric inhibition of P2X receptors by non-ATP-analog antagonists. eLife. 2024, 12:RP92829.
5. Shen C, Zhang Y, Cui W, Zhao Y, Sheng D, Teng X, Shao M, Ichikawa M, Wang J*, Hattori M*. Structural insights into the allosteric inhibition of P2X4 receptors. Nat Commun. 2023, 14(1):6437.
6. Sumino A*, Zhao Y, Mukai D, Sumikama T, Puppulin L, Hattori M*, Shibata M. Antithetic effects of agonists and antagonists on the structural fluctuations of TRPV1 channel. Proc Natl Acad Sci U S A. 2023, 120(20):e2301013120.
7. Jin F, Sun M, Fujii T, Yamada Y, Wang J, Maturana AD, Wada M, Su S, Ma J, Takeda H, Kusakizako T, Tomita A, Nakada-Nakura Y, Liu K, Uemura T, Nomura Y, Nomura N, Ito K, Nureki O, Namba K, Iwata S, Yu Y, Hattori M*. The structure of MgtE in the absence of magnesium provides new insights into channel gating. PLoS Biol. 2021, 19(4):e3001231.
8. Huang Y, Jin F, Funato Y, Xu Z, Zhu W, Wang J, Sun M, Zhao Y, Yu Y, Miki H*, Hattori M*. Structural basis for the Mg2+ recognition and regulation of the CorC Mg2+ transporter. Sci Adv. 2021, 7(7):eabe6140.
9. Jia Y, Zhao Y, Kusakizako T, Wang Y, Pan C, Zhang Y, Nureki O*, Hattori M*, Yan Z*. TMC1 and TMC2 Proteins Are Pore-Forming Subunits of Mechanosensitive Ion Channels. Neuron. 2020, 105(2):310-321.
10. Li M, Wang Y, Banerjee R, Marinelli F, Silberberg S, Faraldo-Gomez J*, Hattori M*, Swartz K*. Molecular mechanisms of human P2X3 receptor channel activation and modulation by divalent cation bound ATP. eLife. 2019, 8:e47060.
11. Wang J, Wang Y, Cui WW, Huang Y, Yang Y, Liu Y, Zhao WS, Cheng XY, Sun WS, Cao P, Zhu MX, Wang R*, Hattori M*, Yu Y*. Druggable negative allosteric site of P2X3 receptors. Proc Natl Acad Sci U S A. 2018, 115(19):4939-4944.