于肖飞

发布时间:2021-06-29浏览次数:8262


教师基本信息:

姓名:于肖飞

职称:青年研究员

职务:

电子邮箱:xiaofei_yu@fudan.edu.cn

办公地点:生命科学学院C323

办公电话:021-31246667

个人网页/课题组主页:www.xyulab.org

 

研究方向:屏障免疫及其介导的远程生理调控

1)免疫细胞对饮食、菌群等环境因素的感知和应答;

2)肠道免疫对机体远端器官的生理调控;

 

个人简介:

教育经历:

2008/07 – 2014/08,(美)德克萨斯大学西南医学中心,生物医学/免疫学,博士,导师: Lora V. Hooper, PhD

2005/08 – 2008/05,(美)爱荷华州立大学,分子细胞及发育生物学,硕士,导师: Yanhai Yin, PhD

2001/09 – 2005/07,复旦大学,生物学,学士

 

科研与学术工作经历:

2019 – 至今             青年研究员    博士生导师

复旦大学,生命科学学院微生物学与免疫系

2014 – 2018        博士后/Helen Hay Whitney Fellow

(美)洛克菲勒大学

导师: Jeffrey M. Friedman, MD, PhD

2014 – 2014        高级研究助理

(美)德克萨斯大学西南医学中心

导师: Lora V. Hooper, PhD

 

授课情况:免疫学(BIOL130026)

 

招生专业:微生物学(分子免疫方向)

 

代表性论文和论著:

1.       Xia M*, Lu J*, Lan J*, Teng T, Shiao R, Sun H, Jin Z, Liu X, Wang J, Wu H, Wang C, Yi H, Qi Q, Li J, Schneeberger M, Shen W, Lu B, Chen L, Ilanges A†, Zhou X†, Yu X†. (2025). Elevated IL-22 as a result of stress-induced gut leakage suppresses septal neuron activation to ameliorate anxiety-like behavior. Immunity 58: 1-14. [PMID: 39644894].

Previewed by: Yang R, He D. Gut know-how: IL-22 from T cells boosts stress resilience. Immunity 58, 10-12 (2025).

Highlighted by: Bird L. IL-22 protects against stress-induced anxiety. Nature Reviews Immunology 25, 75 (2025).

2.       Li X*, Yi H*, Jin Z*, Jiang K*, Xue K, Wang J, Qian Y, Xiang Q, Zhu S, Yan R, Yang Y, Sun S, Li K, Zhou Z, Yu W, Jiang N, Ding C, Lin X, Zhong J, Dong Y, Liu Y†, Yu X†. (2024). MCRS1 sensitizes T cell-dependent immunotherapy by augmenting MHC-I expression in solid tumors. J Exp Med 221(12): e20240959. [PMID: 39545935].

3.       Qi Q*, Zhang H*, Jin Z*, Wang C, Xia M, Chen B, Lv B, Diaz LP, Li X, Feng R, Qiu M, Li Y, Meseguer D, Zheng X, Wang W, Song W, Huang H, Wu H, Chen L†, Schneeberger M†, Yu X†. (2024). Hydrogen Sulfide Produced by the Gut Microbiota Impairs Host Metabolism via Reducing GLP-1 Levels in Male Mice. Nature Metabolism 6(8):1601-1615. [PMID: 39030389].

Previewed by: Zhao N, Wu G, Zhao L. H(2)S as a metabolic saboteur. Nature Metabolism 6, 1431-1432 (2024).

Highlighted by: Carty S. Microbial hydrogen sulfide hampers L-cell GLP-1 production. Nature Reviews Endocrinology 20, 570 (2024).

4.       Xie L*, Li C*, Wang C*, Wu Z*, Wang C, Chen C, Chen X, Zhou D, Zhou Q, Lu P, Ding C, Liu CY, Lin J, Zhang X, Yu X†, Yu W†. (2024). Aspirin-Mediated Acetylation of SIRT1 Maintains Intestinal Immune Homeostasis. Advanced Science (Weinh) 11: e2306378. [PMID:38482749].

5.       Hu W†, Yu X†. (2024). GOSpel for tiny allies. Cell Host and Microbe 32: 450-452. (preview)  [PMID: 38604124].

  1. Yu X* †, Wang Y*, Deng M, Li Y, Ruhn KA, Zhang CC, Hooper LV. (2014).      The basic leucine zipper transcription factor NFIL3 directs the      development of a common innate lymphoid cell precursor. eLife      3: e04406. [PMID: 25310240].

  2. Yu X, Rollins D, Ruhn KA, Stubblefield JJ, Green CB, Kashiwada M,      Rothman PB, Takahashi JS, Hooper LV. (2013). TH17 Cell Differentiation Is      Regulated by the Circadian Clock. Science 342:      727-730. [PMID: 24202171].

Highlighted by: Bordon Y. NFIL3 clocks out TH17 cells. Nature Reviews Immunology 13, 848-848 (2013).

 

教师基本信息:

姓名:Xiaofei Yu

职称:Principal Investigator

职务:

电子邮箱:xiaofei_yu@fudan.edu.cn

办公地点:School of Life Sciences, C323

办公电话:021-31246667

个人网页/课题组主页:www.xyulab.org

 

研究方向:Barrier immunity and its remote regulation of body physiology

1)      Immune sensing and responding to the gut microenvironment, such as the microbiota and diet;

2)      Immune-mediated inter-organ communications between the gut and distal organs.

 

个人简介:

Education

2008/07 – 2014/08, Biomedical Sciences (Immunology), PhD 

The University of Texas Southwestern Medical Center at Dallas, Dallas, Texas, USA.

Mentor: Lora V. Hooper, PhD

2005/08 – 2008/05, Molecular, Cellular and Developmental Biology, MS

Iowa State University, Ames, Iowa, USA.

Mentor: Yanhai Yin, PhD

2001/09 – 2005/07, Biology, BS

Fudan University, Shanghai, China.

 

Employment:

2019 – present, Principal Investigator

Fudan University, School of Life Sciences, State Key Laboratory of Genetic Engineering

2014 – 2018, Postdoctoral Associate/Helen Hay Whitney Fellow

The Rockefeller University, New York, New York.

Mentor: Jeffrey M. Friedman, MD, PhD

2014 – 2014, Senior Research Associate

The University of Texas Southwestern Medical Center at Dallas, Dallas, Texas.

Mentor: Lora V. Hooper, PhD

 

授课情况:Immunology (BIOL130026)

 

招生专业:Microbiologymolecular immunology track

 

代表性论文和论著:

1.       Xia M*, Lu J*, Lan J*, Teng T, Shiao R, Sun H, Jin Z, Liu X, Wang J, Wu H, Wang C, Yi H, Qi Q, Li J, Schneeberger M, Shen W, Lu B, Chen L, Ilanges A†, Zhou X†, Yu X†. (2025). Elevated IL-22 as a result of stress-induced gut leakage suppresses septal neuron activation to ameliorate anxiety-like behavior. Immunity 58: 1-14. [PMID: 39644894].

Previewed by: Yang R, He D. Gut know-how: IL-22 from T cells boosts stress resilience. Immunity 58, 10-12 (2025).

Highlighted by: Bird L. IL-22 protects against stress-induced anxiety. Nature Reviews Immunology 25, 75 (2025).

2.       Li X*, Yi H*, Jin Z*, Jiang K*, Xue K, Wang J, Qian Y, Xiang Q, Zhu S, Yan R, Yang Y, Sun S, Li K, Zhou Z, Yu W, Jiang N, Ding C, Lin X, Zhong J, Dong Y, Liu Y†, Yu X†. (2024). MCRS1 sensitizes T cell-dependent immunotherapy by augmenting MHC-I expression in solid tumors. J Exp Med 221(12): e20240959. [PMID: 39545935].

3.       Qi Q*, Zhang H*, Jin Z*, Wang C, Xia M, Chen B, Lv B, Diaz LP, Li X, Feng R, Qiu M, Li Y, Meseguer D, Zheng X, Wang W, Song W, Huang H, Wu H, Chen L†, Schneeberger M†, Yu X†. (2024). Hydrogen Sulfide Produced by the Gut Microbiota Impairs Host Metabolism via Reducing GLP-1 Levels in Male Mice. Nature Metabolism 6(8):1601-1615. [PMID: 39030389].

Previewed by: Zhao N, Wu G, Zhao L. H(2)S as a metabolic saboteur. Nature Metabolism 6, 1431-1432 (2024).

Highlighted by: Carty S. Microbial hydrogen sulfide hampers L-cell GLP-1 production. Nature Reviews Endocrinology 20, 570 (2024).

4.       Xie L*, Li C*, Wang C*, Wu Z*, Wang C, Chen C, Chen X, Zhou D, Zhou Q, Lu P, Ding C, Liu CY, Lin J, Zhang X, Yu X†, Yu W†. (2024). Aspirin-Mediated Acetylation of SIRT1 Maintains Intestinal Immune Homeostasis. Advanced Science (Weinh) 11: e2306378. [PMID:38482749].

5.       Hu W†, Yu X†. (2024). GOSpel for tiny allies. Cell Host and Microbe 32: 450-452. (preview)  [PMID: 38604124].

  1. Yu X* †, Wang Y*, Deng M, Li Y, Ruhn KA, Zhang CC, Hooper LV. (2014).      The basic leucine zipper transcription factor NFIL3 directs the      development of a common innate lymphoid cell precursor. eLife      3: e04406. [PMID: 25310240].

  2. Yu X, Rollins D, Ruhn KA, Stubblefield JJ, Green CB, Kashiwada M,      Rothman PB, Takahashi JS, Hooper LV. (2013). TH17 Cell Differentiation Is      Regulated by the Circadian Clock. Science 342:      727-730. [PMID: 24202171].

Highlighted by: Bordon Y. NFIL3 clocks out TH17 cells. Nature Reviews Immunology 13, 848-848 (2013).