教师基本信息：
姓名：于肖飞
职称：教授
职务：
电子邮箱：xiaofei_yu@fudan.edu.cn
办公地点：生命科学学院C323
办公电话：021-31246667
个人网页/课题组主页：www.xyulab.org
研究方向：屏障免疫及其介导的远程生理调控
1）免疫细胞对饮食、菌群等环境因素的感知和应答；
2）肠道免疫对机体远端器官的生理调控；
个人简介：
教育经历：
2008/07 – 2014/08，（美）德克萨斯大学西南医学中心，生物医学/免疫学，博士，导师: Lora V. Hooper, PhD
2005/08 – 2008/05，（美）爱荷华州立大学，分子细胞及发育生物学，硕士，导师: Yanhai Yin, PhD
2001/09 – 2005/07，复旦大学，生物学，学士
科研与学术工作经历：
2019 – 至今 青年研究员，教授 博士生导师
复旦大学，生命科学学院微生物学与免疫系
2014 – 2018 博士后/Helen Hay Whitney Fellow
（美）洛克菲勒大学
导师: Jeffrey M. Friedman, MD, PhD
2014 – 2014 高级研究助理
（美）德克萨斯大学西南医学中心
导师: Lora V. Hooper, PhD
授课情况:免疫学(BIOL130026)
招生专业：微生物学（分子免疫方向）
代表性论文和论著：
1. Xia M*, Lu J*, Lan J*, Teng T, Shiao R, Sun H, Jin Z, Liu X, Wang J, Wu H, Wang C, Yi H, Qi Q, Li J, Schneeberger M, Shen W, Lu B, Chen L, Ilanges A†, Zhou X†, Yu X†. (2025). Elevated IL-22 as a result of stress-induced gut leakage suppresses septal neuron activation to ameliorate anxiety-like behavior. Immunity 58: 1-14. [PMID: 39644894].
Previewed by: Yang R, He D. Gut know-how: IL-22 from T cells boosts stress resilience. Immunity 58, 10-12 (2025).
Highlighted by: Bird L. IL-22 protects against stress-induced anxiety. Nature Reviews Immunology 25, 75 (2025).
2. Li X*, Yi H*, Jin Z*, Jiang K*, Xue K, Wang J, Qian Y, Xiang Q, Zhu S, Yan R, Yang Y, Sun S, Li K, Zhou Z, Yu W, Jiang N, Ding C, Lin X, Zhong J, Dong Y, Liu Y†, Yu X†. (2024). MCRS1 sensitizes T cell-dependent immunotherapy by augmenting MHC-I expression in solid tumors. J Exp Med 221(12): e20240959. [PMID: 39545935].
3. Qi Q*, Zhang H*, Jin Z*, Wang C, Xia M, Chen B, Lv B, Diaz LP, Li X, Feng R, Qiu M, Li Y, Meseguer D, Zheng X, Wang W, Song W, Huang H, Wu H, Chen L†, Schneeberger M†, Yu X†. (2024). Hydrogen Sulfide Produced by the Gut Microbiota Impairs Host Metabolism via Reducing GLP-1 Levels in Male Mice. Nature Metabolism 6(8):1601-1615. [PMID: 39030389].
Previewed by: Zhao N, Wu G, Zhao L. H(2)S as a metabolic saboteur. Nature Metabolism 6, 1431-1432 (2024).
Highlighted by: Carty S. Microbial hydrogen sulfide hampers L-cell GLP-1 production. Nature Reviews Endocrinology 20, 570 (2024).
4. Xie L*, Li C*, Wang C*, Wu Z*, Wang C, Chen C, Chen X, Zhou D, Zhou Q, Lu P, Ding C, Liu CY, Lin J, Zhang X, Yu X†, Yu W†. (2024). Aspirin-Mediated Acetylation of SIRT1 Maintains Intestinal Immune Homeostasis. Advanced Science (Weinh) 11: e2306378. [PMID:38482749].
5. Hu W†, Yu X†. (2024). GOSpel for tiny allies. Cell Host and Microbe 32: 450-452. (preview) [PMID: 38604124].
Yu X* †, Wang Y*, Deng M, Li Y, Ruhn KA, Zhang CC, Hooper LV. (2014). The basic leucine zipper transcription factor NFIL3 directs the development of a common innate lymphoid cell precursor. eLife 3: e04406. [PMID: 25310240].
Yu X, Rollins D, Ruhn KA, Stubblefield JJ, Green CB, Kashiwada M, Rothman PB, Takahashi JS, Hooper LV. (2013). TH17 Cell Differentiation Is Regulated by the Circadian Clock. Science 342: 727-730. [PMID: 24202171].
Highlighted by: Bordon Y. NFIL3 clocks out TH17 cells. Nature Reviews Immunology 13, 848-848 (2013).
教师基本信息：
姓名：Xiaofei Yu
职称：Principal Investigator
职务：
电子邮箱：xiaofei_yu@fudan.edu.cn
办公地点：School of Life Sciences, C323
办公电话：021-31246667
个人网页/课题组主页：www.xyulab.org
研究方向：Barrier immunity and its remote regulation of body physiology
1) Immune sensing and responding to the gut microenvironment, such as the microbiota and diet;
2) Immune-mediated inter-organ communications between the gut and distal organs.
个人简介：
Education
2008/07 – 2014/08, Biomedical Sciences (Immunology), PhD
The University of Texas Southwestern Medical Center at Dallas, Dallas, Texas, USA.
Mentor: Lora V. Hooper, PhD
2005/08 – 2008/05, Molecular, Cellular and Developmental Biology, MS
Iowa State University, Ames, Iowa, USA.
Mentor: Yanhai Yin, PhD
2001/09 – 2005/07, Biology, BS
Fudan University, Shanghai, China.
Employment:
2019 – present, Principal Investigator
Fudan University, School of Life Sciences, State Key Laboratory of Genetic Engineering
2014 – 2018, Postdoctoral Associate/Helen Hay Whitney Fellow
The Rockefeller University, New York, New York.
Mentor: Jeffrey M. Friedman, MD, PhD
2014 – 2014, Senior Research Associate
The University of Texas Southwestern Medical Center at Dallas, Dallas, Texas.
Mentor: Lora V. Hooper, PhD
授课情况：Immunology (BIOL130026)
招生专业：Microbiology（molecular immunology track）
代表性论文和论著：
1. Xia M*, Lu J*, Lan J*, Teng T, Shiao R, Sun H, Jin Z, Liu X, Wang J, Wu H, Wang C, Yi H, Qi Q, Li J, Schneeberger M, Shen W, Lu B, Chen L, Ilanges A†, Zhou X†, Yu X†. (2025). Elevated IL-22 as a result of stress-induced gut leakage suppresses septal neuron activation to ameliorate anxiety-like behavior. Immunity 58: 1-14. [PMID: 39644894].
Previewed by: Yang R, He D. Gut know-how: IL-22 from T cells boosts stress resilience. Immunity 58, 10-12 (2025).
Highlighted by: Bird L. IL-22 protects against stress-induced anxiety. Nature Reviews Immunology 25, 75 (2025).
2. Li X*, Yi H*, Jin Z*, Jiang K*, Xue K, Wang J, Qian Y, Xiang Q, Zhu S, Yan R, Yang Y, Sun S, Li K, Zhou Z, Yu W, Jiang N, Ding C, Lin X, Zhong J, Dong Y, Liu Y†, Yu X†. (2024). MCRS1 sensitizes T cell-dependent immunotherapy by augmenting MHC-I expression in solid tumors. J Exp Med 221(12): e20240959. [PMID: 39545935].
3. Qi Q*, Zhang H*, Jin Z*, Wang C, Xia M, Chen B, Lv B, Diaz LP, Li X, Feng R, Qiu M, Li Y, Meseguer D, Zheng X, Wang W, Song W, Huang H, Wu H, Chen L†, Schneeberger M†, Yu X†. (2024). Hydrogen Sulfide Produced by the Gut Microbiota Impairs Host Metabolism via Reducing GLP-1 Levels in Male Mice. Nature Metabolism 6(8):1601-1615. [PMID: 39030389].
Previewed by: Zhao N, Wu G, Zhao L. H(2)S as a metabolic saboteur. Nature Metabolism 6, 1431-1432 (2024).
Highlighted by: Carty S. Microbial hydrogen sulfide hampers L-cell GLP-1 production. Nature Reviews Endocrinology 20, 570 (2024).
4. Xie L*, Li C*, Wang C*, Wu Z*, Wang C, Chen C, Chen X, Zhou D, Zhou Q, Lu P, Ding C, Liu CY, Lin J, Zhang X, Yu X†, Yu W†. (2024). Aspirin-Mediated Acetylation of SIRT1 Maintains Intestinal Immune Homeostasis. Advanced Science (Weinh) 11: e2306378. [PMID:38482749].
5. Hu W†, Yu X†. (2024). GOSpel for tiny allies. Cell Host and Microbe 32: 450-452. (preview) [PMID: 38604124].
Yu X* †, Wang Y*, Deng M, Li Y, Ruhn KA, Zhang CC, Hooper LV. (2014). The basic leucine zipper transcription factor NFIL3 directs the development of a common innate lymphoid cell precursor. eLife 3: e04406. [PMID: 25310240].
Yu X, Rollins D, Ruhn KA, Stubblefield JJ, Green CB, Kashiwada M, Rothman PB, Takahashi JS, Hooper LV. (2013). TH17 Cell Differentiation Is Regulated by the Circadian Clock. Science 342: 727-730. [PMID: 24202171].
Highlighted by: Bordon Y. NFIL3 clocks out TH17 cells. Nature Reviews Immunology 13, 848-848 (2013).