姓名：李烁钧 Shuojun Li
职称：助理教授A(tenure track)
职务：课题组长（PI），博士生导师
电子邮箱：shuojunli@gmail.com
办公地点：复旦大学江湾校区生命科学学院
研究方向：
研究聚焦化学生物学与生物医学交叉，致力于构建外部信号精准调控的智能纳米平台，利用化学工具理解并操控复杂生物体系。主要方向包括（1）细胞表面工程化与免疫创新疗法（2）新型分子标记工具开发与拓展（3）多尺度纳米递送平台与功能调控。
欢迎有志于从事上述研究的博士后、研究生加盟研究团队。
Dr. Li’s research lies at the interface of chemical biology and biomedicine, with a focus on the design of intelligent nanoplatforms that can be precisely regulated by external physical or chemical signals. His group aims to develop chemical tools to understand and manipulate complex biological systems. The main directions include (1) Cell-surface engineering and innovative immunotherapy. (2) Development of novel molecular labeling tools. (3) Multilevel nano delivery platforms and functional regulation.
We welcome motivated postdoctoral researchers and graduate students to join our team.
个人简介：
李烁钧，男，1995年生。2017年本科毕业于华中农业大学化学专业，2023年获化学生物学博士学位，同年加入中国科学院分子细胞卓越创新中心从事博士后研究。2025年加盟复旦大学生命科学学院任助理教授。研究长期致力于推动生物与化学学科间交叉融合，开拓新的研究领域。在 Nature、Angewandte等期刊发表多篇研究成果，被Nature Chemical Biology, Cancer Discovery等期刊及媒体专题报道。
Shuojun Lireceived his B.S. degree in Chemistry from Huazhong Agricultural University in 2017 and his Ph.D. in Chemical Biology in 2023. He then joined the Center for Excellence in Molecular Cell Science, Chinese Academy of Sciences, as a postdoctoral researcher. In 2025, he was appointed as an Assistant Professor at the School of Life Sciences, Fudan University. His research focuses on bridging chemistry and biology to pioneer new research fields. He has published multiple papers in journals such as Nature and Angewandte, with his work highlighted by Nature Chemical Biology, Cancer Discovery, and other international media outlets.
招生专业：生物化学(化学生物学与免疫调控方向)、合成生物学
科研项目：
上海市超级博士后，主持
博士后自然科学基金，主持
国家自然科学基金面上项目，参与
国家自然科学基金重大研究计划，参与
代表性论文和论著：
1. Shuojun Li#, Yinghui Men#, Zihan Wang#, Yingcheng Wu#, Hao Sun, Mingyang Yin, Xinrui Fan, Guiyun Deng, Zhicheng Yang, Tiange Yang, Yudian Xiao, Hu Zhou, Guangchuan Wang, Jia Fan, Chenqi Xu, Qiang Gao*, Shuo Han*; Amplifying antigen-induced cellular responses with proximity labeling. Nature. 2025, s41586-025-09518-6.
l Highlighted by Nature Chemical Biology, 21, 1643 (2025), Cancer Discovery, doi.org/10.1158/2159-8290.CD-RW2025-092 (2025).
2. Shuojun Li; Jiaying Li; Moqing Du; Guiyun Deng; Zhiyong Song; Heyou Han*; EfficientGeneSilencing in Intact Plant Cells Using siRNA Delivered By Functional Graphene Oxide Nanoparticles,Angewandte Chemie, 2022, 134: e202210014 (Hot Paper)
3. Shuojun Li#; Moqing Du#; Jiamin Deng; Guiyun Deng; Jiaying Li; Zhiyong Song; Heyou Han*;Geneediting of Duchenne muscular dystrophy using biomineralization-based spCas9 variant nanoparticles, Acta Biomaterialia, 2022, 154: 597-607
4. Shuojun Li#; Yuying Long#; Guiyun Deng; Yinghui Men; Feifan Lu; Zihan Wang; Jiaying Li; Heyou Han*; Manganese-based nanozyme enables efficient mitigation of Huanglongbing-induced oxidative damage in Citrus, Environmental Science: Nano,2025,12: 701-715
5. Shuojun Li#; Zhiyong Song#; Caiyun Liu; Xiao-Lin Chen*; Heyou Han*; Biomimetic Mineralization-Based CRISPR/Cas9 Ribonucleoprotein Nanoparticles for Gene Editing, ACS Applied Materials & Interfaces, 2019, 11(51): 47762-47770
6. Shuojun Li#; Yumei Sun#; Moqing Du; Aishao Shangguan; Zhongzhu Liu; Wentao Li; Liu Lina; Wenju Liu; Shujun Zhang*; Heyou Han*; Graphene Oxide Nanoparticles Combined with CRISPR/Cas9 System Enable Efficient Inhibition of Pseudorabies Virus, Bioconjugate Chemistry, 2023, 34: 326-332
7. Jiaying Li#,Shuojun Li#,Moqing Du, Zhiyong Song, and Heyou Han*. Nuclear Delivery of Exogenous Gene in Mature Plants Using Nuclear Location Signal and Cell-Penetrating Peptide Nanocomplex, ACS Appl. Nano Mater, 2023, 6, 160−170
8, Guiyun Deng#, Feifan Lu#, Shuojun Li#, Yuying Long, Jianghong Wu, Xiaofeng Guo, Chunyin Li, Zhiyong Song, Mohamed F. Foda, Fang Ding*, Heyou Han*. A two-in-one molybdenum disulfide-chitosan nanoparticles system for activating plant defense mechanisms and reactive oxygen species to treat Citrus Huanglongbing, Int. J. Biol. Macromol,2024, 280, 135528