姓名：孙继晟
职称：青年研究员
电子邮箱：jisheng_sun@fudan.edu.cn
研究方向：
本课题组以斑马鱼和小鼠为主要研究模型，聚焦于心脏与脑血管系统的再生研究。我们综合运用单细胞测序、谱系示踪、类器官模型及多组学分析等前沿技术，系统解析组织再生的细胞与分子机制及其药物开发。课题组致力于在基础研究与临床转化之间搭建桥梁，为心血管和脑血管相关疾病的治疗提供新的理论依据与创新路径。
Our group employs zebrafish and mouse models to investigate the cardiac and cerebrovascular systems. By integrating single-cell sequencing, lineage tracing, organoid models, and multi-omics approaches, we aim to elucidate the cellular and molecular mechanisms underlying regeneration and facilitate drug development. Our goal is to bridge basic research and clinical application, laying the foundation for innovative therapies targeting cardiovascular and cerebrovascular diseases.
个人简介：
孙继晟，男，青年研究员，博士生导师，2010年于华东师范大学获得生物科学专业学士，2017年于中科院生物化学与细胞生物学研究所获得生物化学与分子生物学博士学位，2017-2023年于Emory University医学院从事博士后研究，2023-2025年于Emory University医学院担任Instructor。2025年8月加入复旦大学生命科学学院，入选上海市人才项目。以第一作者在Circulation, Nature Communications, Cardiovascular Research, Cell Reports和Developmental Biology等国际期刊发表多篇论文。
Dr. Jisheng Sun earned his bachelor’s degree in biology from East China Normal University in 2010. He received his Ph.D. in 2017 from the Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, under the mentorship of Dr. Anning Lin. Dr. Sun then joined the Emory University School of Medicine as a postdoctoral fellow in Dr. Jinhu Wang’s lab and was subsequently appointed as an Instructor. In August 2025, he joined the School of Life Sciences at Fudan University to establish his laboratory. Dr. Sun’s research has been published as first author in leading journals, including Circulation, Nature Communications, Cardiovascular Research, Cell Reports, and Developmental Biology.
招生专业：细胞生物学 （Cell Biology），发育生物学 (Developmental Biology)
代表性论文和论著：
1. Jisheng Sun, Elizabeth A. Peterson, Xin Chen, and Jinhu Wang. (2024). ptx3a+ fibroblast/epicardial cells provide a transient macrophage niche to promote heart regeneration. Cell Rep. 43(4):114092.
2. Qian Xu#, Jisheng Sun#, Claire M. Holden, Hildebrando Candido Ferreira Neto, Ti Wang, Chiyuan Zhang, Zuli Fu, Giji Joseph, Ruizheng Shi, Jinhu Wang, Andrew Leask, W Robert Taylor, Zhiyong Lin. (2024). CCN2 regulates smooth muscle cell trans-differentiation and lipid accumulation in atherosclerosis. Cardiovasc Res.cvae215.
3. Kwangdeok Shin, Anjelica Rodriguez-Parks, Chanul Kim, Isabella M. Silaban, Yu Xia, Jisheng Sun, Chenyang Dong, Sunduz Keles, Jinhu Wang, Jingli Cao, Junsu Kang. Harnessing the regenerative potential of interleukin11 to enhance heart repair. Nat Commun. 15, 9666 (2024).
4. Elizabeth A. Peterson, Jisheng Sun, Xin Chen, and Jinhu Wang. (2024). Neutrophils facilitate the epicardial regenerative response after zebrafish heart injury. Dev Biol.508:93-106.
5. Jisheng Sun, Elizabeth A. Peterson, Xin Chen, and Jinhu Wang. (2023). hapln1a+ cells guide coronary growth during heart morphogenesis and regeneration. Nat Commun. 14(1):3505.
6. Jisheng Sun, Elizabeth A. Peterson, Annabel Z. Wang, Jianhong Ou, Kieko E. Smith, Kenneth D. Poss, and Jinhu Wang. (2022). hapln1 defines an epicardial cell subpopulation required for cardiomyocyte expansion during heart morphogenesis and regeneration. Circulation.146:48–63.
7. Jisheng Sun, Elizabeth A. Peterson, Cheng Jiao, Xin Chen, Yun Zhao and Jinhu Wang. (2022). Zebrafish heart regeneration after coronary dysfunction-induced cardiac damage. Dev Biol. 487:57-66.
8. Elizabeth A. Peterson, Jisheng Sun, Jinhu Wang. (2022). Leukocyte-Mediated Cardiac Repair after Myocardial Infarction in Non-Regenerative vs. Regenerative Systems. J Cardiovasc Dev Dis. 9(2):63.
9. Jie Yan, Jialing Xia, Yutin Lin, Jingui Ma, Jiyan Zhang, Hao Zhang, Jisheng Sun, Nika N.Danial, Jing Liu, and Anning Lin. (2013). Inactivation of BAD by IKK inhibits TNFalpha-induced apoptosis independently of NF-kappaB activation.Cell. 152(1-2):304-15.