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课程表及讲者课程简介:
Statistical Genomics Workshop
Lecturers:
TPS: Terence Paul Speed (UC Berkeley & WEHI)
WW: Wenyi Wang (UT MD Anderson Cancer Center)
AT: Andrew Teschendorff (UCL & CAS-MPG PICB)
Day 1 (6/24): Statistical methods for analysis of whole-transcriptome data.
9:30-10:30: Removing unwanted variation (TPS)
10:45-11:45: Removing unwanted variation from RNA-seq data (TPS)
Lunch break
1:30-2:30: Normalizing large, heterogeneous datasets in the omics (TPS)
2:45-3:45: Deconvolution of mixed transcriptomes from tumor samples (WW)
Day 2 (6/25): Statistical methods for variant calling in high-throughput sequencing data.
9:30-10:30: Challenges in rare variant calling, what we learned from targeted sequencing studies. (WW)
10:45-11:45: Family-based analysis for calling rare variant in DNA sequencing data (WW)
Lunch break
1:30-2:30: Comparing mutation callers (TPS)
2:45-3:45: Combining mutation callers (TPS)
Day 3 (6/26). Statistical methods for personalized risk assessment in inherited cancer syndromes.
9:30-10:30: Mendelian models. (WW)
10:45-11:45: Challenges in application of Mendelian models to various cancer types. (WW)
Lunch break
12:30-3:00 Lab workshop on two software packages: BayesMendel, and FamSeq (WW)
Day 4 (6/27). Statistical Epigenomics
9:30-10:30: Intra-and inter-sample normalization of Illumina 450k data. (AT)
10:45-11:45: Correction for cellular heterogeneity using devonvolution tools
Lunch break. (AT)
1:30-2:30: General feature selection strategies for EWAS and Cancer Epigenome studies. (AT)
Day 5 (6/28). Statistical Epigenomics
9:30-10:30: Dimensional reduction and clustering of DNA methylation data. (AT)
10:45-11:45: Integration of DNA methylation and gene expression data. (AT)
End of the workshop
Software and links:
- Terry Speed: http://www.wehi.edu.au/people/terry-speed
- Andrew Teschendorff: https://www.ucl.ac.uk/cancer/rescancerbiol/statisticalgenomics
For the summer workshop: http://www.picb.ac.cn/compsysg/
- Wenyi Wang: http://odin.mdacc.tmc.edu/~wwang7/
Software:
FamSeq: http://bioinformatics.mdanderson.org/main/FamSeq
BayesMendel: http://bcb.dfci.harvard.edu/bayesmendel/