2015统计基因组学讲习班

发布者:系统管理员发布时间:2015-06-09浏览次数:2414

报名回执表下载:

/Assets/userfiles/sys_4b0b77af-788b-419d-b0be-a42e00eec678/files/%E6%9A%91%E6%9C%9F%E5%AD%A6%E6%A0%A1%E8%AE%B2%E4%B9%A0%E7%8F%AD%E6%8A%A5%E5%90%8D%E5%9B%9E%E6%89%A7(1).docx

 

课程表及讲者课程简介:

/Assets/userfiles/sys_4b0b77af-788b-419d-b0be-a42e00eec678/files/%E8%AF%BE%E7%A8%8B%E8%A1%A8%E5%92%8C3%E8%AE%B2%E8%80%85%E8%AF%BE%E7%A8%8B%E7%AE%80%E4%BB%8B.docx

 

Statistical Genomics Workshop

 

Lecturers:

TPS: Terence Paul Speed (UC Berkeley & WEHI)

WW: Wenyi Wang (UT MD Anderson Cancer Center)

AT: Andrew Teschendorff (UCL & CAS-MPG PICB)

 

Day 1 (6/24): Statistical methods for analysis of whole-transcriptome data.

 

9:30-10:30: Removing unwanted variation (TPS)

10:45-11:45: Removing unwanted variation from RNA-seq data (TPS)

Lunch break

1:30-2:30: Normalizing large, heterogeneous datasets in the omics (TPS)

2:45-3:45: Deconvolution of mixed transcriptomes from tumor samples (WW)

 

Day 2 (6/25): Statistical methods for variant calling in high-throughput sequencing data.

9:30-10:30: Challenges in rare variant calling, what we learned from targeted sequencing studies. (WW)

10:45-11:45: Family-based analysis for calling rare variant in DNA sequencing data (WW)

Lunch break

1:30-2:30: Comparing mutation callers (TPS)

2:45-3:45: Combining mutation callers (TPS)

 

Day 3 (6/26). Statistical methods for personalized risk assessment in inherited cancer syndromes.

9:30-10:30: Mendelian models. (WW)

10:45-11:45: Challenges in application of Mendelian models to various cancer types. (WW)

Lunch break

12:30-3:00 Lab workshop on two software packages: BayesMendel, and FamSeq (WW)

 

Day 4 (6/27). Statistical Epigenomics

9:30-10:30: Intra-and inter-sample normalization of Illumina 450k data. (AT)

10:45-11:45: Correction for cellular heterogeneity using devonvolution tools

Lunch break. (AT)

1:30-2:30: General feature selection strategies for EWAS and Cancer Epigenome studies. (AT)

 

Day 5 (6/28). Statistical Epigenomics

9:30-10:30: Dimensional reduction and clustering of DNA methylation data. (AT)

10:45-11:45: Integration of DNA methylation and gene expression data. (AT)

End of the workshop

 

Software and links:

 

  1. Terry Speed: http://www.wehi.edu.au/people/terry-speed
  2. Andrew Teschendorff: https://www.ucl.ac.uk/cancer/rescancerbiol/statisticalgenomics

For the summer workshop: http://www.picb.ac.cn/compsysg/

  1. Wenyi Wang: http://odin.mdacc.tmc.edu/~wwang7/

 

Software:

FamSeq: http://bioinformatics.mdanderson.org/main/FamSeq

BayesMendel: http://bcb.dfci.harvard.edu/bayesmendel/