教师基本信息
职称：教授
电子邮箱：huiru_tang（at）fudan.edu.cn (at means @)
办公地点：复旦生科院D105室
办公电话：021-31246725
个人简介
国家杰出青年科学基金获得者、英国皇家化学会会士、复旦大学特聘教授、国家重点研发计划项目首席。1986年获西北轻工业学院（现陕西科技大学）学士、1994年获伦敦大学博士学位。1992-2005年先后在英国BBSRC食品研究所、帝国理工学院生物医学部任Senior Scientist等职。2005-14年先后任中科院武汉物数所研究员、博导、研究部副主任、中科院生物磁共振分析重点实验室创建主任。2014年加盟复旦大学生命科学学院。曾任英国NHS、科技部973及蛋白质重大计划等评审专家、J Proteome Res编委。在Nature及PNAS等上发表SCI论文210余篇，被引1.2万余次（h指数~63）。获批发明专利6项。部分工作被Science、Nature等作为“研究亮点”专文评述。现任国际实验核磁共振大会（ENC）执委、中国生物物理学会代谢组学分会会长、自由基生物学及医学分会常务理事、生物磁共振专委会委员，中国抗癌协会肿瘤代谢专委会常务理事，中国营养学会基础营养学分会理事，Metabolomics、Curr Metabolomics、Arch Pharm和《基础医学与临床》等编委，Nutrition & Metabolism及Phenomics等副主编。
Personal website: http://www.metabolome.cn/
研究方向
聚焦代谢物结构功能及代谢组学30余年，发展高通量超灵敏代谢组学、代谢组与转录组/蛋白质组/微生物组数据整合分析等技术，研究重大疾病发生发展及有效干预的分子基础。曾主持国家杰出青年科学基金、国家重点研发计划、国家自然科学基金重大、973课题等项目多项。现承担国家重点研发计划、国家创新群体、上海市级重大专项等任务。
荣誉及获奖情况（Awards）
英国皇家化学会会士（2005）、国家杰出青年科学基金（2008）、新世纪百千万人才工程国家级人选称号（2009）、王天眷波谱学奖（2010）、武汉市优秀科技工作者（2011）。
1. Y. B. Feng, et al, “Anopheline mosquitoes are protected against parasite infection by tryptophan catabolism in gut microbiota”, Nat Microbiol, 7:707-715, 2022.【IF~31】
2. Z. M. Hou, et al, “Inhibiting 3bHSD1 to eliminate the oncogenic effects of progesterone in prostate cancer”, Cell Rep Med, 3:100561, 2022.【IF~17】
3. J. H. Liu, et al, “Simultaneous quantification of 70 elements in biofluids within 5 min using inductively coupled plasma mass spectrometry to reveal elementomic phenotypes of healthy Chinese adults”, Talanta, 238:123720, 2022.【IF~6.6】
4. Q. Y. Hu, et al, “Quantitative structure-retention relationship for reliable metabolite identification and quantification in metabolomics using ion-pair reversed-phase chromatography coupled with tandem mass spectrometry”, Talanta, 238:123059, 2022.【IF~6.6】
5. M. F. Xia, et al, “NAFLD-related gene polymorphisms and all-cause and cause-specific mortality in an Asian population: the Shanghai Changfeng Study”, Aliment Pharm Ther, 55:705-21, 2022【IF~9.5】
6. M. F. Xia, et al, “Insights into contribution of genetic variants towards the susceptibility of MAFLD revealed by the NMR_based lipoprotein profiling”, J Hepatol, 74:974-977, 2021.【IF~30】
7. Y. Xu, et al, “Asparagine reinforces mTORC1 signaling to boost thermogenesis and glycolysis in adipose tissues”, EMBO J, e108069, 2021.【IF~14】
8. M. Wang, et al, “Glucose-mediated proliferation of a gut commensal bacterium promotes Plasmodiuminfection by increasing mosquito midgut pH”, Cell Rep, 35:108992, 2021【IF~10】
9. R. Loo, et al, “A feasibility study of metabolic phenotyping of dried blood spot specimens in rural Chinese women exposed to household air pollution”, J Expo Sci Env Epid, 31:328, 2021【IF~6.4】
10. Y. P. An, et al, “Development and validation of an improved probabilistic quotient normalization method for LC/MS- and NMR-based metabonomic analysis”, Chin Chem Lett, 31:1827, 2020.【IF~8.5】
11. J. Xue, et al, “A vitamin-C-derived DNA modification catalysed by an algal TET homologue”, Nature, 569:581–585, 2019【IF~69】
12. H. Lin, et al, “Alterations of bile acids and gut microbiota in obesity induced by high fat diet in rat model”, JAFC, 67:3624. 2019.【IF~5.9; 高被引, 年均20余次】
13. J. Gou, et al, “Discovery of a non-stereoselective cytochrome P450 catalyzing either 8α- or 8β-hydroxylation of germacrene A acid from the Chinese medicinal plant, Inula hupehensis”, Plant J, 93:92-106, 2018.【IF~7.1】
14. F. Chen, et al, “Combined metabonomic and quantitative RT-PCR analyses revealed metabolic reprogramming associated with Fusarium graminearum resistance in transgenic Arabidopsis thaliana”, Front Plant Sci, 8:2177, 2018.【IF~6.6】
15. L. Zhang, et al, “Metabolomics reveals that dietary ferulic acid and quercetin modulate metabolic homeostasis in rats”, J Agric Food Chem, 66: 1723−1731, 2018. 【IF~5.9】
16. C. Liu, et al, Dynamic metabolic responses of brown planthoppers towards susceptible and resistant rice plants, Plant Biotechnol J, 15:1346, 2017.【IF~13】
17. Q. Wan, et al, Quantitative 13C traces of glucose fate in hepatitis B virus infected hepatocytes, Anal Chem, 89:3293–3299, 2017【IF~8】
18. H. Li, et al, Decreased glutathione biosynthesis contributes to EGFR T790M-driven erlotinib resistance in non-small cell lung cancer, Cell Discov, 2:16031, 2016.【IF~38】
19. L. Sun, et al, cMyc-mediated activation of serine biosynthesis pathway is critical for cancer progression under nutrient deprivation conditions, Cell Res, 25:429, 2015.【IF~46】
20. M. Li, et al, “Human symbiotic gut microbes specifically modulate metabolic phenotypes”, PNAS, 105:2117-2122, 2008.【IF~12.8; 高被引, 年均被引>50次】
论文及引用Full Publication List [>5 citations per annum for 79 papers]
https://publons.com/researcher/2776607/huiru-tang/