冯喆

发布者:彭筱葳发布时间:2022-01-21浏览次数:368

教师基本信息:

姓名:冯喆

职务:青年研究员,博师生导师

电子邮箱:zhefeng@fudan.edu.cn

办公地点:复旦大学生命科学学院A407

信息板块:

主要研究方向

中心体的组装与调控机制;

中心体功能障碍对于癌症、发育类等疾病的致病机理;

相分离介导的无膜细胞器组装和调控的功能机理。

个人简介

2011年获英国帝国理工大学学士学位,2016年获英国牛津大学病理学博士学位(Prof. Jordan Raff实验组,硕博连读)。此后在同实验室从事博士后研究。2017年入职香港科技大学,担任研究助理教授(张明杰院士实验室组),获选港科大高研院青年学人荣誉,领导主持香港研究资助局优配研究金项目。2021年获得国家和上海人才计划支持,人才引进复旦大学生命科学院。

  

招生专业

细胞与发育生物学、生物化学、结构生物学、遗传学

代表性论文和论著

1. Feng, Z., Jia, B., Tao, J. and Zhang, M. (2021) “IRSp53 promotes postsynaptic density formation and actin filament bundling via phase separation”. Journal of Cell Biology, under revision.

2. Feng, Z.*, Caballe, A.*, Wainman, A.*, Johnson, S.*, Haensele, A.F.M., Cottee, M.A., Conduit, P.T., Lea, S.M., and Raff, J.W. (2017) “Structural basis for mitotic centrosome assembly in flies”. Cell169, 1078-1089. (Highlighted in Faculty 1000)

3. Conduit, P.T.*, Feng, Z.*(Equal contribution), Richens, J.H., Baumbach, J., Wainman, A., Bakshi, S., Dobbelaere, J., Johnson, S., Lea, S.M., and Raff, J.W. (2014) “The centrosome-specific phosphorylation of Cnn by Polo/Plk1 drives Cnn scaffold assembly and centrosome maturation”. Developmental Cell 28, 659-669. (Highlighted in Faculty 1000)

4. Feng, Z., Jia, B., and Zhang, M. (2021) “Liquid-liquid phase separation in biology: specific stoichiometric molecular interactions vs promiscuous interactions mediated by disordered sequences”. Biochemistry 60, 2397-2406.

5. Wu, X., Cai, Q., Feng, Z., and Zhang, M. (2020) “Liquid-liquid phase separation in neuronal development and synaptic signaling”. Developmental Cell 55, 18-29.

6. Feng, Z.,Chen, X., Wu, X., and Zhang, M. (2019) “Formation of biological condensates via phase separation: Characteristics, analytical methods, and physiological implications”. Journal of Biological Chemistry294, 14823-14835.

7. Li, Z., Liu, H., Li, J., Yang, Q., Feng, Z., Li, Y., Yang, H., Yu, C., Wan, J., Liu, W., and Zhang, M. (2019) “Homer tetramer promotes actin bundling activity of Drebrin”. Structure27, 27-38.

8. Feng, Z., Chen, X., Zeng, M., and Zhang, M. (2018) “Phase separation as a mechanism for assembling dynamic postsynaptic density signaling complexes”. Current Opinion in Neurobiology 57, 1-8.

9. Feng, Z., Zeng, M., Chen, X., and Zhang, M. (2018) “Neuronal synapses: microscale signal processing machineries formed by phase separation?”. Biochemistry 57, 2530-2539.



Zhe Feng

PositionYoung Investigator (Tenure track)

Emailzhefeng@fudan.edu.cn

AddressRoom A407, Institute of Life Science, Fudan University

Major research directions:

Structural and functional basis underlying centrosome assembly and organization.

How is centrosome dysfunction linked to cancer and developmental diseases?

Phase separation-mediated membraneless organelle formation and regulation.

  

Education and research background:

Zhe Feng received her bachelor’s degree in Biochemistry at Imperial College London in 2011. She was a PhD student with Prof. Jordan Raff at University of Oxford, where she performed structural and functional characterization of major scaffold proteins in centrosomes. She then worked as a Research Assistant Professor/IAS junior fellow with Prof. Mingjie Zhang at HKUST, focused on phase separation-driven non-membrane bound organelle assembly and regulation. She joins the Institute of Life Science, Fudan in 2021.

  

Admissions Major

Developmental and Cell Biology, Biochemistry, Structural Biology, Genetics.

  

Selected Publications

1. Feng, Z., Jia, B., Tao, J. and Zhang, M. (2021) “IRSp53 promotes postsynaptic density formation and actin filament bundling via phase separation”. Journal of Cell Biology, under revision.

2. Feng, Z.*, Caballe, A.*, Wainman, A.*, Johnson, S.*, Haensele, A.F.M., Cottee, M.A., Conduit, P.T., Lea, S.M., and Raff, J.W. (2017) “Structural basis for mitotic centrosome assembly in flies”. Cell169, 1078-1089. (Highlighted in Faculty 1000)

3. Conduit, P.T.*, Feng, Z.*(Equal contribution), Richens, J.H., Baumbach, J., Wainman, A., Bakshi, S., Dobbelaere, J., Johnson, S., Lea, S.M., and Raff, J.W. (2014) “The centrosome-specific phosphorylation of Cnn by Polo/Plk1 drives Cnn scaffold assembly and centrosome maturation”. Developmental Cell 28, 659-669. (Highlighted in Faculty 1000)

4. Feng, Z., Jia, B., and Zhang, M. (2021) “Liquid-liquid phase separation in biology: specific stoichiometric molecular interactions vs promiscuous interactions mediated by disordered sequences”. Biochemistry 60, 2397-2406.

5. Wu, X., Cai, Q., Feng, Z., and Zhang, M. (2020) “Liquid-liquid phase separation in neuronal development and synaptic signaling”. Developmental Cell 55, 18-29.

6. Feng, Z.,Chen, X., Wu, X., and Zhang, M. (2019) “Formation of biological condensates via phase separation: Characteristics, analytical methods, and physiological implications”. Journal of Biological Chemistry294, 14823-14835.

7. Li, Z., Liu, H., Li, J., Yang, Q., Feng, Z., Li, Y., Yang, H., Yu, C., Wan, J., Liu, W., and Zhang, M. (2019) “Homer tetramer promotes actin bundling activity of Drebrin”. Structure27, 27-38.

8. Feng, Z., Chen, X., Zeng, M., and Zhang, M. (2018) “Phase separation as a mechanism for assembling dynamic postsynaptic density signaling complexes”. Current Opinion in Neurobiology 57, 1-8.

9. Feng, Z., Zeng, M., Chen, X., and Zhang, M. (2018) “Neuronal synapses: microscale signal processing machineries formed by phase separation?”. Biochemistry 57, 2530-2539.