题目：Stem cell regulation and cancer development in the brain
报告人: Yuan Zhu
时 间：2015年6月18日（星期四）上午10点
地 点：复旦大学江湾新校区生科大楼A208会议室
1994-2000：Ph.D. Program in Neuroscience (advisor: Luis F. Parada)University of Texas Southwestern Medical Center
at Dallas, Dallas, Texas
2000-2002: Post-doctoral training in Cancer Biology (advisor: Luis F. Parada) University
of Texas Southwestern Medical Center at Dallas, Dallas, Texas
2002-2003：Instructor Center for Developmental Biology, University of Texas
Southwestern Medical Center at Dallas, Dallas, Texas
2003-2010：Assistant Professor Division of Molecular Medicine and Genetics
Departments of Internal Medicine and Cell & Developmental
Biology, University of Michigan Medical School, Ann Arbor, MI
2010-2013：Associate Professor with tenure Division of Molecular Medicine and Genetics, Departments of Internal
Medicine and Cell & Developmental Biology, University of Michigan Medical School, Ann Arbor, MI
2013- present :Scientific Director and Gilbert Family Professor of Neurofibromatosis , Children's National Medical
Center, Washington, DC
Main research fields:
1. Using mouse genetics to study the molecular and cellular mechanisms underlying initiation and progression of tumors in both central nervous system (CNS) and peripheral nervous system (PNS). 2. Exploring mouse models to address: (1) how tumor suppressor genes regulate the stem cell function including self-renewal, survival, differentiation and migration, (2) how inactivation of tumor suppressor genes transforms neural stem cells or endow differentiated cells with stem cell characteristics, and (3) how normal stem cells or differentiated cells become cancer stem cells.
Selected publications:
1. Zheng, H.*, Chang, L.*, Patel, N., Yang, J., Lowe, L., Burns, D.K. and Zhu, Y. (2008). Induction of abnormal proliferation by nonmyelinating Schwann cells triggers neurofibroma formation. Cancer Cell, 13:117-128 (*Co-first author).
2. Wang, Y.*, Yang, J.*, Zheng, H., Tomasek, G.J., Zhang, P., McKeever, P.E., Lee, E.P. and Zhu, Y. (2009). Expression of mutant p53 proteins implicates a lineage relationship between neural stem cells and malignant astrocytic glioma in a murine model. Cancer Cell, 15(6):514-26 (*Co-first author). PMCID: PMC2721466.
3. Huson, S.M., Acosta, M.T., Belzberg, A.J., Bernards, A., Chernoff, J., Cichowski, K., Gareth, E.D., Ferner, R.E., Giovannini, M., Korf, B.R., Listernick, R., North, K.N., Packer, R.J., Parada, L.F., Peltonen, J., Ramesh, V., Reilly, K.M., Risner, J.W., Schorry, E.K., Upadhyaya, M., Viskochil, D.H., Zhu, Y., Hunter-Schaedle, K., Giancotti, F.G. (2011). Back to the future: Proceedings from the 2010 NF Conference. American Journal of Medical Genetics. 2010 Dec 22. [Epub ahead of print] PubMed PMID: 21182011.
4. Wang, Y., Kim, E., Wang, X., Novitch, B.G., Yoshikawa, K., Chang, L.S. and Zhu, Y. (2012). ERK inhibition rescues defects in fate-specification of Nf1-deficient neural progenitors and brain abnormalities. Cell, 150(4):816-830. PubMed PMID: 22901811.
5. Kim, E., Wang, Y., Kim, S., Bornhorst, M., Jecrois, E.S., Anthony. T.E., Wang, C., Li, Y.E., Guan, J., Murphy, G.G., Zhu, Y (2014). Transient inhibition of the ERK pathway prevents cerebellar developmental defects and improves long-term motor functions in murine models of neurofibromatosis type 1. eLife. 2014 Dec 23;3. doi: 10.7554/eLife.05151. [Epub ahead of print] PubMed PMID: 25535838.