Title: Epigenetic regulation of aging
Speaker: Weiwei Dang, Ph.D.（Assistant Professor, Huffington Center on Aging, Baylor College of Medicine）
时间：2015年7月 7日（周二）下午1:30
地点：江湾新校区生科楼B303会议室
复旦大学遗传工程国家重点实验室特邀学术报告:
Dr. Dang received his Bachalor from Peking Universiy and Ph.D. degree in Microbiology, Biochemistry, and Molecular Biology from Southern Illinois University in 2006. He then did postdoctoral training in Dr. Shelley Berger’s laboratory at University of Pennsylvania. In 2013, Dr. Dang was recruited to the Baylor College of Medicine and appointed Assistant Professor in the Huffington Center on Aging and the department of Molecular and Human Genetics. He was also named CPRIT Scholar for Cancer Research by the Cancer Prevention and Research Institute of Texas.
Research Interests:
My research focuses on how chromatin and epigenetic pathways are involved in regulation of aging and age-related diseases. We use the budding yeast replicative aging as a model to determine how various histone modifications change during aging and how epigenetic regulators regulate longevity through chromatin remodeling. I have also developed an innovative and high throughput longevity screen method based on old cell sorting and barcode sequencing, which will significantly accelerate the discovery of molecular pathways of aging. Stem cell aging and cellular senescence are important processes that contribute to the aging pathology and development of age-associated diseases. As a complement and extension to the yeast replicative aging model, we use mammalian primary cell lines and mesenchymal stem cells (MSC) to study whether the epigenetic pathways identified in model systems are conserved and how they are involved in cellular senescence and adult stem cell aging. In particular, we are interested in how epigenetic changes are playing a role in regulating differentiation capabilities and preferences for MSCs during aging.
5 Most Significant Publications:
- MC Jo, W Liu, W Dang#, L Qin#. High-throughput analysis of yeast replicative aging using a novel microfluidic system. Proceedings of the National Academy of Sciences of the United States of America. (2015) In press. (# indicates co-corresponding authors.)
- P Sen*, W Dang*#, G Donahue, J Dai, J Dorsey, X Cao, W Liu, K Cao, R Perry, JY Lee, J Wagner, B Gregory, M Kaeberlein, BK Kennedy, J Boeke, and SL Berger#. H3K36 methylation promotes longevity by enhancing transcription fidelity. Genes & Development. (2015) In press. (* indicates equal contribution; # indicates co-corresponding authors.)
- W Dang, GL Sutphin, J Dorsey, GL Otte, K Cao, R Perry, JJ Wanat, D Saviolaki, CJ Murakami, S Tsuchiyama, B Robison, BD Gregory, M Vermeulen, R Shiekhattar, FB Johnson, BK Kennedy, M Kaeberlein, and SL Berger. Inactivation of yeast Isw2 chromatin remodeling enzyme mimics longevity effect of calorie restriction via induction of genotoxic stress response. Cell Metabolism. (2014) 19: 952-966. PubMed ID: 24814484.
- W Dang, KK Steffen, R Perry, J Dorsey, FB Johnson, A Shilatifard, M Kaeberlein, BK Kennedy, and SL Berger. Histone H4 lysine-16 acetylation regulates cellular lifespan. Nature. (2009) 459: 802-807. PubMed ID: 19516333.
- W Dang and B Bartholomew. Architecture of the ATP-dependent Chromatin Remodeling Complex ISW2. Molecular and Cellular Biology. (2007) 26: 8306–8317. PubMed ID: 17908792.
