教师基本信息:
姓名:胡长龙
职称:研究员
电子邮箱:clhu@fudan.edu.cn
办公地点:复旦大学生命科学学院C211室
办公电话:021-31246651
研究方向:细胞膜离子通道的功能与调控,以及离子通道异常引起的相关疾病的研究:(1)离子通道对醛固酮以及胰岛素的分泌调控;(2)离子通道对神经兴奋性及神经损伤修复调控的研究。
个人简介:
博士,研究员,博士生导师。2005年毕业于复旦大学生命科学学院,获理学博士学位;2005年7月至2009年12月,在美国弗吉尼亚大学从事博士后研究;2010年-至今,先后任复旦大学生命科学学院副教授、研究员。主持或参与多项国家自然科学基金面上项目以及国家重点研发计划。2007年获Posdoctoral Fellowship Award(American Heart Association)。2009年获教育部自然科学二等奖(第3完成人)。
授课情况:生理学;细胞分子生物学;膜片钳技术和细胞膜离子通道
招生专业:生理学,神经生物学,生物物理学
代表性论文和论著:
1.Pan C, Ying Liu, Wang L, Fan W, Ni Y, Zhang X, Wu D, Li C, Li J, Li Z, Liu R, Hu C*. The Kv2.2 channel mediates the inhibition of Prostaglandin E2 on glucose-stimulated insulin secretion in pancreatic β-cells. eLife. 2024 https://doi.org/10.7554/eLife.97234.1.
2. Wan D, Lu T, Li C, Hu C*. Glucocorticoids rapidly modulate CaV1.2-mediated calcium signals through Kv2.1 channel clusters in hippocampal neurons. J Neurosci. 2024 Sep 19: e0179242024.
3. Wang Y, Zhang Y, Hu J, Gao Y, Liu Q, Xu W, Xue L, Hu C*.Glucocorticoids modulate neural activity via a rapid non-genomic effect on Kv2.2 channels in the central nervous system.Neurobiology of Stress, 2024, 28:100593.
4. Li Z.Dong W, Zhang X, Lu J, Mei YA, Hu C*. Protein Kinase C Controls the Excitability of Cortical Pyramidal Neurons by Regulating Kv2.2 Channel Activity. Neurosci Bull, 2022. 38(2): p. 135-148.
5. Yang T, He M, Zhang H, Barrett PQ, Hu C*. L- and T-type calcium channels control aldosterone production from human adrenals. J Endocrinol, 2020, 244: 237-247.
6.He M, Xu Z, Zhang Y, Hu C*. Splice-variant-specific effects of primary aldosteronism point mutations on human Cav3.2 calcium channels. Cell Calcium, 2019, 84: 102104.
7.Yang T,Zhang, Hai-Liang,Liang, Qingnan,Shi, Yingtang,Mei, Yan-Ai,Barrett, Paula Q,Hu C *. Small-Conductance Ca2+-Activated Potassium Channels Negatively Regulate Aldosterone Secretion in Human Adrenocortical Cells. Hypertension, 2016,68(3):785~7953.Name: Changlong Hu
Primary appointment: Professor, Physiology and Neurobiology
Contact Information:
Email:clhu@fudan.edu.cn
Tel: 021-31246651
Address: Room C211, School of life sciences, Fudan University
Education:
Ph.D. Neurobiology, Fudan University
Postdoc,Pharmacology, University of Virginia
Research Interests:
Regulation and function of ion channels, and human diseases associated with defects in ion channels.
Selected Publications:
1.Pan C, Ying Liu, Wang L, Fan W, Ni Y, Zhang X, Wu D, Li C, Li J, Li Z, Liu R, Hu C*. The Kv2.2 channel mediates the inhibition of Prostaglandin E2 on glucose-stimulated insulin secretion in pancreatic β-cells. eLife. 2024 https://doi.org/10.7554/eLife.97234.1.
2. Wan D, Lu T, Li C, Hu C*. Glucocorticoids rapidly modulate CaV1.2-mediated calcium signals through Kv2.1 channel clusters in hippocampal neurons. J Neurosci. 2024 Sep 19: e0179242024.
3. Wang Y, Zhang Y, Hu J, Gao Y, Liu Q, Xu W, Xue L, Hu C*.Glucocorticoids modulate neural activity via a rapid non-genomic effect on Kv2.2 channels in the central nervous system.Neurobiology of Stress, 2024, 28:100593.
4. Li Z.Dong W, Zhang X, Lu J, Mei YA, Hu C*. Protein Kinase C Controls the Excitability of Cortical Pyramidal Neurons by Regulating Kv2.2 Channel Activity. Neurosci Bull, 2022. 38(2): p. 135-148.
5. Yang T, He M, Zhang H, Barrett PQ, Hu C*. L- and T-type calcium channels control aldosterone production from human adrenals. J Endocrinol, 2020, 244: 237-247.
6.He M, Xu Z, Zhang Y, Hu C*. Splice-variant-specific effects of primary aldosteronism point mutations on human Cav3.2 calcium channels. Cell Calcium, 2019, 84: 102104.
7.Yang T,Zhang, Hai-Liang,Liang, Qingnan,Shi, Yingtang,Mei, Yan-Ai,Barrett, Paula Q,Hu C *. Small-Conductance Ca2+-Activated Potassium Channels Negatively Regulate Aldosterone Secretion in Human Adrenocortical Cells. Hypertension, 2016,68(3):785~7953.