教师基本信息：
姓名：郑媛婷Yuanting Zheng
职称：特聘教授Distinguished professor
职务：现代人类学教育部重点实验室副主任
电子邮箱：zhengyuanting@fudan.edu.cn
办公地点：复旦大学生命科学学院D610室
个人网页/课题组主页：http://fudan-pgx.org/fudanpgx/#/home
研究方向：
（1）多组学数据标准和质量控制（https://chinese-quartet.org/）
（2）多组学驱动的药物基因组和表型组研究（http://fudan-pgx.org/chihope/）
课题组长期招聘有志于相关领域研究的本科生、研究生、博士后。
个人简介：
复旦大学生命科学学院特聘教授、附属中山医院双聘教授，博士研究生导师，现代人类学教育部重点实验室副主任。国家自然科学基金青年科学基金项目（A类）获得者。兼任国际组学数据质量控制（MAQC）学会副主席、MAQC学会中国分会主席、全国生物表型标准化工作组委员兼副秘书长、全国生物计量技术委员会委员等。
主要研究方向为多组学数据标准和质量控制，促进多组学技术在生物标志物和药靶发现中的可靠应用。作为共同PI领导研制国际首例“中华家系”(Quartet)1号多组学标准物质，获国家市场监督管理总局批准的国家一级标准物质12项，提出基于标准物质的多组学测量质量控制指标和比例定量（SRR）的数据整合方法，相关研究成果被自然专刊收录(www.nature.com/collections/ibadeahigd)，获中国2023年度重要医学进展。已发表SCI论文90余篇，包括以通讯作者（含共同）发表Nature Biotechnology、Nature Cancer、Nature Communications、Genome Biology等；共同主编《大数据与精准医学》一书(2018)。
2009年博士毕业于中国药科大学，先后在复旦大学药学院、生命科学学院担任讲师，2017年2月晋升副教授，2025年2月晋升长聘教职体系特聘教授。
Dr. Yuanting Zheng is a Distinguished Professor in the School of Life Sciences, Fudan University. Her research focuses on developing reference samples for multiomics quality control and data integration, thereby advancing the translational application of multiomics technologies in clinical settings. As a co-leader of the Multiomics Quartet project, she has contributed to reproducibility research and published in top-tier journals such as Nature Biotechnology and Genome Biology (www.nature.com/collections/ibadeahigd). Dr. Yuanting Zheng holds leadership roles as the vice president of the MAQC Society (https://themaqc.org/). Dr. Yuanting Zheng received her PhD in clinical pharmacology from China Pharmaceutical University.
授课情况：
本研融通课程《精准医学数据标准化和质量控制》（课程代码：BIOL20004.01）
招生专业：
科学学位：生物学（遗传学）
工程学位：生物与医药（精准医学大数据）
科研项目：
1. 国家自然科学基金青年科学基金项目（A类），多组学数据标准和质量控制(T2425013)，主持，2025.1~2029.12。
2. 上海市2024年度“科技创新行动计划”计算生物学领域项目，多组学数据标准化技术及分子分型产品开发和临床应用(24JS2840100)，主持，2024.12~2027.11。
3. 科技部科技基础资源调查专项“人基因组测序标准参考数据建设”(2022FY101203)，主持，2022.10~2025.09。（结题）
4. 国家重点研发计划“战略性国际科技创新合作”重点专项“人类表型组学数据融合分析的质量控制技术研究”(2018YFE0201603)，主持，2019.08~2022.07。（结题）
获奖情况：
基于“中华家系1号”标准物质提出多组学分析的质量控制指标和整合方法，中国2023年度重要医学进展。
代表性论文和论著：
1. Qiaochu Chen, Zehui Cao, Yaqing Liu, Naixin Zhang, Yanming Xie, Haonan Chen, Yuanbang Mai, Shumeng Duan, Jiaqi Li, Ying Yu, Yang Zhao, Leming Shi*, Yuanting Zheng*. Protein-level batch-effect correction enhances robustness in MS-based proteomics. Nat Commun. 2025; 16(1): 9735.
2. Xiaorou Guo#, Qingwang Chen#, Yuanfeng Zhang#, Yujing Zhang#, Yaqing Liu, Shumeng Duan, Yu Ma, Peng Ni, Jianxin Wang, Bo He, Luyao Ren, Ruiwen Ma, Wanwan Hou, Ying Yu, Bingsi Li, Fujun Qiu, Yuan Sun, Zhihong Zhang, Weihong Xu, Xiang Fang, Jinming Li, Leming Shi*, Rui Zhang*, Yuanting Zheng*, Lianhua Dong*. Methylation reference datasets from quartet DNA materials for benchmarking epigenome sequencing.Nat Commun. 2025; 16(1): 9202.
3. Ying Yu#, Wanwan Hou#, Qingwang Chen#, Xiaorou Guo, Leqing Sang, Hao Xue, Duo Wang, Jinming Li, Xiang Fang, Rui Zhang*, Lianhua Dong*, Leming Shi*, Yuanting Zheng*. Construction of RNA reference materials for improving the quantification of transcriptomic data. Nat Protoc. 2025; 20(8): 2209-2237.
4. Yi-Zhou Jiang#,*, Ding Ma#, Xi Jin#, Yi Xiao#, Ying Yu#, Jinxiu Shi#, Yi-Fan Zhou, Tong Fu, Cai-Jin Lin, Lei-Jie Dai, Cheng-Lin Liu, Shen Zhao, Guan-Hua Su, Wanwan Hou, Yaqing Liu, Qingwang Chen, Jingcheng Yang, Naixin Zhang, Wen-Juan Zhang, Wei Liu, Weigang Ge, Wen-Tao Yang, Chao You, Yajia Gu, Virginia Kaklamani, François Bertucci, Claire Verschraegen, Anneleen Daemen, Nakul M. Shah, Ting Wang, Tiannan Guo, Leming Shi, Charles M. Perou, Yuanting Zheng*, Wei Huang*, Zhi-Ming Shao*. Integrated molecular portraits of breast cancer reveal therapeutic targets. Nature Cancer 2024; 5(4): 673-690.
5. Naixin Zhang#, Qiaochu Chen#, Peipei Zhang#, Kejun Zhou, Yaqing Liu, Haiyan Wang, Shumeng Duan, Yongming Xie, Wenxiang Yu, Ziqing Kong, Luyao Ren, Wanwan Hou, Jingcheng Yang, Xiaoyun Gong, Lianhua Dong, Xiang Fang, Leming Shi, Ying Yu*, Yuanting Zheng*. Quartet metabolite reference materials for inter-laboratory proficiency test and data integration of metabolomics profiling. Genome Biology. 2024; 25(1): 34.
6. Yuanting Zheng#,*, Yaqing Liu#, Jingcheng Yang#, Lianhua Dong#, Rui Zhang#, Sha Tian#, Ying Yu, Luyao Ren, Wanwan Hou, Feng Zhu, Yuanbang Mai, Jinxiong Han, Lijun Zhang, Hui Jiang, Ling Lin, Jingwei Lou, Ruiqiang Li, Jingchao Lin, Huafen Liu, Ziqing Kong, Depeng Wang, Fangping Dai, Ding Bao, Zehui Cao, Qiaochu Chen, Qingwang Chen, Xingdong Chen, Yuechen Gao, He Jiang, Bin Li, Bingying Li, Jingjing Li, Ruimei Liu, Tao Qing, Erfei Shang, Jun Shang, Shanyue Sun, Haiyan Wang, Xiaolin Wang, Naixin Zhang, Peipei Zhang, Ruolan Zhang, Sibo Zhu, Andreas Scherer, Jiucun Wang, Jing Wang, Yinbo Huo, Gang Liu, Chengming Cao, Li Shao, Joshua Xu, Huixiao Hong, Wenming Xiao, Xiaozhen Liang, Daru Lu, Li Jin, Weida Tong, Chen Ding*, Jinming Li*, Xiang Fang*, Leming Shi*. Multi-omics data integration using ratio-based quantitative profiling with Quartet reference materials. Nature Biotechnology 2024; 42(7): 1133-1149.
7. Ying Yu#, Wanwan Hou#, Yaqing Liu#, Haiyan Wang#, Lianhua Dong#, Yuanbang Mai, Qingwang Chen, Zhihui Li, Shanyue Sun, Jingcheng Yang, Zehui Cao, Peipei Zhang, Yi Zi, Ruimei Liu, Jian Gao, Naixin Zhang, Jingjing Li, Luyao Ren, He Jiang, Jun Shang, Sibo Zhu, Xiaolin Wang, Tao Qing, Ding Bao, Bingying Li, Bin Li, Chen Suo, Yan Pi, Xia Wang, Fangping Dai, Andreas Scherer, Pirkko Mattila, Jinxiong Han, Lijun Zhang, Hui Jiang, Danielle Thierry-Mieg, Jean Thierry-Mieg, Wenming Xiao, Huixiao Hong, Weida Tong, Jing Wang, Jinming Li, Xiang Fang, Li Jin, Joshua Xu*, Feng Qian*, Rui Zhang*, Leming Shi*, Yuanting Zheng*. Quartet RNA reference materials improve the quality of transcriptomic data through ratio-based profiling. Nature Biotechnology 2024; 42(7): 1118-1132.
8. Luyao Ren#, Xiaoke Duan#, Lianghua Dong#, Rui Zhang#, Jingcheng Yang#, Yuechen Gao, Rongxue Peng, Wanwan Hou, Yaqing Liu, Jingjing Li, Ying Yu, Naixin Zhang, Jun Shang, Fan Liang, Depeng Wang, Hui Chen, Lele Sun, Lingtong Hao, The Quartet Project Team, Andreas Scherer, Jessica Nordlund, Wenming Xiao, Joshua Xu, Weida Tong, Xin Hu, Peng Jia, Kai Ye, Jinming Li, Li Jin, Huixiao Hong*, Jing Wang*, Shaohua Fan*, Xiang Fang*, Yuanting Zheng*, Leming Shi. Quartet DNA reference materials and datasets for comprehensively evaluating germline variants calling performance. Genome Biology 2023; 24(1): 270.
9. Ying Yu#, Naixin Zhang#, Yuanbang Mai#, Luyao Ren#, Qiaochu Chen, Zehui Cao, Qingwang Chen, Yaqing Liu, Wanwan Hou, Jingcheng Yang, Huixiao Hong, Joshua Xu, Weida Tong, Lianhua Dong, Leming Shi*, Xiang Fang*, Yuanting Zheng*. Correcting batch effects in large-scale multiomics studies using a reference-material-based ratio method. Genome Biology 2023; 24(1): 201.
10.Jingcheng Yang#, Yaqing Liu#, Jun Shang#, Qiaochu Chen, Qingwang Chen, Luyao Ren, Naixin Zhang, Ying Yu, Zhihui Li, Yueqiang Song, Shengpeng Yang, Andreas Scherer, Weida Tong, Huixiao Hong, Wenming Xiao, Leming Shi*, Yuanting Zheng*. The Quartet Data Portal: integration of community-wide resources for multiomics quality control. Genome Biology 2023; 24(1): 245.