教师基本信息：
姓名：赵昭昭 Zhaozhao Zhao
职称：助理教授B Assistant Professor B (Tenure track)
电子邮箱：zhaozhaozhao@fudan.edu.cn
办公地点：生命科学学院E601-5
研究方向：整合多组学数据、深度学习模型等解析基因表达及非编码序列调控
个人简介：
2026年4月加入复旦大学生命科学学院，担任倪挺教授课题组的co-PI，博士生导师。2023年6月获复旦大学生物信息学专业博士学位，同年6月至2026年3月在复旦大学人类表型组研究院从事博士后研究。研究聚焦于从非编码序列调控的独特视角出发，整合多组学数据，深入解析衰老相关疾病的分子机制，旨在为精准干预提供新靶点和新策略。相关成果发表于 Science Advances、Nature Communications、Genome Research、Nucleic Acids Research等期刊。
I joined the School of Life Sciences at Fudan University as a co-PI in Professor Ni Ting's research group and as a doctoral supervisor. I obtained my Ph.D. in Bioinformatics from Fudan University in June 2023, and subsequently conducted postdoctoral research at the Human Phenome Institute of Fudan University from June 2023 to March 2026. My research focuses on elucidating the molecular mechanisms of aging-related diseases from the unique perspective of non-coding sequence regulation, integrating multi-omics data to identify new targets and strategies for precision intervention. Related findings have been published in journals such as Science Advances, Nature Communications, Genome Research, and Nucleic Acids Research.
招生专业：生物信息学、遗传学
科研项目：
（1）国家自然科学基金委员会, 青年科学基金项目（C类）[原青年科学基金项目], 32400437, 可变串联转录起始介导的基因表达调控在癌症中的作用及机制, 2025-01-01 至 2027-12-31, 30万元, 在研, 主持
（2）中国博士后科学基金会, 面上资助项目, 2023M740709, 隐秘转录起始事件在肿瘤内异质性中的作用及机制, 2023-11 至今, 8万元, 结题, 主持
获奖情况：
（1）谈家桢博士后学者奖（2024）
（2）全国博士后创新人才支持计划（2023）
（3）上海市超级博士后（2023）
（4）上海市优秀毕业生（2023）
代表性论文和论著：
1. Zhao Z#, Chen Y#, Zou X#, Lin L#, Zhou X, Cheng X, Yang G, Xu Q, Gong L, Li L*, Ni T*. Pan-cancer transcriptome analysis reveals widespread regulation through alternative tandem transcription initiation. Sci Adv. 2024 Jul 12;10(28).
2. Zhao Z#, Chen Y#, Cheng X, Huang L, Wen H, Xu Q, Zhou X, Zhang X, Chen J*, Ni T*. The landscape of cryptic antisense transcription in human cancers reveals an oncogenic noncoding RNA in lung cancer. Sci Adv. 2023 Apr 5;9(14).
3. Zhao Z#, Xu Q#, Wei R, Huang L, Wang W, Wei G*, Ni T*. Comprehensive characterization of somatic variants associated with intronic polyadenylation in human cancers. Nucleic Acids Res. 2021 Oct 11;49(18).
4. Zhao Z, Xu Q, Wei R, Wang W, Ding D, Yang Y, Yao J, Zhang L, Hu YQ, Wei G*, Ni T*. Cancer-associated dynamics and potential regulators of intronic polyadenylation revealed by IPAFinder using standard RNA-seq data. Genome Res. 2021 Nov;31(11):2095-2106.
5. Xu Q#, Cheng X#, Li Q, Yu P, Zhou X, Chen Y, Lin L, Ni T*, Zhao Z*. 3′ untranslated region somatic variants connect alternative polyadenylation dysregulation in human cancers. J Genet Genomic. 2025 Mar 17:S1673-8527(25)00079-7.