徐书华

发布者:王诗铭发布时间:2021-07-09浏览次数:239

教师基本信息

姓名:徐书华

职称:特聘教授(二级)

职务:研究组长(PI

电子邮箱:xushua@fudan.edu.cn

办公地点:生命科学学院C611

办公电话:021-31246617

个人网页/课题组主页:www.pog.fudan.edu.cnwww.picb.ac.cn/PGG/


个人简介

徐书华无党派人士;2006年博士毕业于复旦大学,同年入职中科院-马普学会计算生物学伙伴研究所,历任助理研究员、副研究员、研究员;2009年建立群体基因组学研究组(PGG);2012-2018年担任德国马普学会和中科院共同支持的青年科学家小组组长;2013年兼任上海科技大学特聘教授、入选首批万人计划青年拔尖人才;2015年任中科院特聘研究员(核心骨干)、获国家杰出青年基金;2016年入选上海市优秀学术带头人;2018年兼任中科院动物进化与遗传前沿交叉卓越创新中心特聘研究员、入选科技部中青年科技创新领军人才;2019年获英国皇家学会牛顿高级访问学者基金资助;20217月入职复旦大学任特聘教授,建立人类群体组学实验室(POG)。兼任遗传学会理事、上海市遗传学会常务理事、上海市人类学会理事;兼任多个SCI学术期刊编委如Molecular Genetics and Genomics共同主编Scientific ReportsHuman GenomicsHereditasBMC Genomic Data资深编辑Senior Editor)。


研究方向

群体组学/人类遗传/分子进化/生物信息学/计算生物学

发展和运用群体遗传学方法和计算生物学手段,致力于研究人群遗传结构、环境适应和微观进化等方面的科学问题;Science, Cell,PNAS, Nature Genetics, Nature Communications, Genome Biology, The American Journal of Human Genetics, Nucleic Acids Research, Genome Research, Molecular Biology and Evolution等期刊发表SCI收录学术论文100多篇、被引用4600多次、单篇最高被引用570次以上。承担国家自然基金委重大研究计划集成项目、重点项目、面上项目、新冠应急专项、中科院先导专项、上海市市级重大专项、科技部重点研发计划研究课题;中科院青年科学家奖、中科院院长奖(导师)、教育部自然科学一等奖、国家自然科学二等奖


学术任职

  • Molecular Genetics and Genomics(德国)(SCI收录)共同主编2021.06~)

  • Frontier in Genetics(美国) (SCI收录)AssociateEditor2021.05~)

  • BMC Genomic Data(英国)(SCI收录)资深编辑(Senior Editor2021.05~)

  • Journal of Genetics and Genomics(中国)(SCI收录)编委2020.07~)

  • 中国遗传学会,理事2018.11~)

  • 中国妇幼保健协会精准医学专业委员会,常务委员2018.11~)

  • 深圳华大生命科学研究院,高级科学顾问(2018.04 2020.04

  • 《生命科学》,编委2018.9~)

  • 中国生物化学与分子生物学会分子系统生物学专业委员会,委员2017~)

  • Genes & Genetic Systems(日本)Associate Editor2017~)

  • 复旦大学教育部重点实验室,学术委员会,委员(2017.12 – 2022.12

  • 上海市遗传学会,常务理事2015.11~)

  • Hereditas(英国)(SCI收录)编委2015.10~)

  • BMC Genetics(英国)(SCI收录)编委(Section Editor2014.07~)

  • Human Genomics(英国)(SCI收录)编委2014.01~)

  • Scientific Reports(英国)(SCI收录)编委2014.01~)

  • Molecular Genetics and Genomics(德国)(SCI收录)编委2013.01~)

  • 分子系统生物学专委会,委员2013~)

  • 中国遗传学会青年委员会,委员20132018

  • 上海科技大学,特聘教授(兼)2012.10~)

  • 上海市人类学会,理事2012.08~)

  • 上海市遗传学会,理事2011.08~)

  • 菲律宾国家基因组中心(PGC学术顾问2011.08-2016.07

  • 马来亚大学计算信息生物学研究中心(CRYSTAL学术顾问20092013


荣誉与奖励

  • Journal of Genetics and Genomics 2020年度优秀编委奖(2020

  • 英国皇家学会牛顿高级访问学者(剑桥大学)(2019-2022

  • 遗传与发育协同创新中心2019年度“十大科技进展”(2020

  • 2019年度中国生物信息学十大进展(2020

  • 2019年度中国生物信息学十大数据库(2020

  • 入选科技部中青年科技创新领军人才(2018

  • 中科院院长奖(导师)(2018

  • 教育部自然科学一等奖(第5完成人)(2018

  • 入选上海市优秀学术带头人计划(2016

  • 入选“中国科学院特聘研究员” -- 特聘核心骨干(2015

  • 中国科学院青年创新促进会(首届)“优秀会员”(2015

  • 国家杰出青年科学基金 (2015

  • 国家自然科学二等奖(第2完成人)(2015

  • 中国科学院上海分院“青年五四奖章”(2015

  • 上海市遗传学会杰出贡献奖(2015

  • 中国科学院青年创新促进会2012-2013年度“优秀会员”(2013

  • 入选国家“万人计划”第一批“青年拔尖人才”(2013

  • 中科院青年科学家奖(2012

  • 中科院上海生科院-美国礼来公司优秀毕业论文导师奖(2012

  • 中科院上海分院第三届杰出青年科技人才奖(2012

  • 教育部自然科学奖(一等)(第2完成人)(2012

  • 上海市科技启明星(2011

  • 全国百篇优秀博士学位论文(2011

  • 入选首届中国科学院青年创新促进会(2011

  • 复旦大学优秀博士学位论文(2010

  • 上海市优秀博士学位论文(2009

  • 法国赛诺菲-安万特-上海生科院青年人才奖(2009

  • 日本明治乳业生命科学奖(2009

  • 中国科学院卢嘉锡青年人才奖(2009

社会团体任职

 •第七届上海中青年知识分子联谊会,理事(2020.05~)

 •上海市少数民族联合会第八届理事会,理事(2020.12~)

 •上海市科技系统中青年知识分子联谊会,理事(2019.01~)

 •无党派人士,中共上海组织部(2018.05~)


代表性论著

  1. Xixian Ma#, Wenjun Yang#, Yang Gao, Yuwen Pan, Yan Lu, Hao Chen, Dongsheng Lu, Shuhua Xu*. Genetic origins and sex-biased admixture of the Huis. Molecular Biology and Evolution. 2021. Doi:10.1093/molbev/msab158.

  2. Lian Deng and Shuhua Xu*. Population Genomics of High-Altitude Adaptation (Book Chapter in Evolution of the Human Genome II, Book edited by Dr. Saitou, University of Tokyo, Japan), Springer, (ISBN 978-4-431-56902-2). 2021, Page: 67-100.

  3. Xinjun Zhang , Kelsey E Witt , Mayra M Bañuelos , Amy Ko , Kai Yuan , Shuhua Xu, Rasmus Nielsen, Emilia Huerta-Sanchez*. The history and evolution of the Denisovan-EPAS1 haplotype in Tibetans. PNAS. 2021, 118(22): e2020803118.

  4. Lan-Tao Gou, Yang Gao, Jun-Yan Kang, Xin Wang, Hao Chen, Min-Min Hua, Zheng Li, Dangsheng Li, Xiang-Dong Fu, Hui-Juan Shi*, Shuhua Xu* and Mo-Fang Liu*. Reply to Lack of evidence for a role of PIWIL1 variants in human male infertility. Cell. 2020. 184(8):1943-1944.

  5. Hao Chen#, Yan Lu#, Dongsheng Lu & Shuhua Xu*. Y-LineageTracker: a high-throughput analysis framework for Y-chromosomal next-generation sequencing data. BMC Bioinformatics. 2021. 22:114.

  6. Ziqing Pan and Shuhua Xu*. Population genomics of East Asian ethnic groups. Hereditas. 2020. 157:49.

  7. Yang Gao#, Chao Zhang#, Liyun Yuan#, YunChao Ling, Xiaoji Wang, Chang Liu, Yuwen Pan, Xiaoxi Zhang, Xixian Ma, Yuchen Wang, Yan Lu, Kai Yuan, Wei Ye, Jiaqiang Qian, Huidan Chang, Ruifang Cao, Xiao Yang, Ling Ma, Yuanhu Ju, Long Dai, Yuanyuan Tang, The Han100K Initiative, Guoqing Zhang, Shuhua Xu*.  PGG.Han: The Han Chinese Genome Database and Analysis Platform. Nucleic Acids Research2020, 48(D1):D971-D976.

  8. Ouzhuluobu, Yaoxi He, Haiyi Lou, Chaoying Cui, Lian Deng, Yang Gao, Wangshan Zheng, Yongbo Guo, Xiaoji Wang, Zhilin Ning, Jun Li, Bin Li, Caijuan Bai, Baimakangzhuo, Gonggalanzi, Dejiquzong, Bianba, Duojizhuoma, Shiming Liu, Tianyi Wu, Shuhua Xu*, Xuebin Qi*, Bing Su*. De novo assembly of a Tibetan genome and identification of novel structural variants associated with high altitude adaptation. National Science Review2020, 7(2):391-402.

  9. Chao Zhang#, Yang Gao#, Zhilin Ning#, Yan Lu#, Xiaoxi Zhang, Jiaojiao Liu, Bo Xie, Zhe Xue, Xiaoji Wang, Kai Yuan, Xueling Ge, Yuwen Pan, Chang Liu, Lei Tian, Yuchen Wang, Dongsheng Lu, Boon-Peng Hoh, Shuhua Xu*.  PGG.SNV: Understanding the evolutionary and medical implications of human single nucleotide variations in diverse populations. Genome Biology2019, 20:215.

  10. Lian Deng#, Chao Zhang#, Kai Yuan#, Yang Gao#, Yuwen Pan, Xueling Ge, Yaoxi He, Yuan Yuan, Yan Lu, Xiaoxi Zhang, Hao Chen, Haiyi Lou, Xiaoji Wang, Dongsheng Lu, Jiaojiao Liu, Lei Tian, Qidi Feng, Asifullah Khan, Yajun Yang, Zi-Bing Jin, Jian Yang, Fan Lu, Jia Qu, Longli Kang, Bing Su, Shuhua Xu*. Prioritizing natural selection signals from the deep-sequencing genomic data suggests multi-variant adaptation in Tibetan highlanders. National Science Review2019, 6(6):1201–1222.

  11. Xin Luo#, Yaoxi He#, Chao Zhang#, Xiechao He#, Lanzhen Yan#, Min Li, Ting Hu, Yan Hu, Jin Jiang, Xiaoyu Meng, Weizhi Ji, Xudong Zhao, Ping Zheng*, Shuhua Xu* & Bing Su*. Trio deep-sequencing does not reveal unexpected off-target and on-target mutations in Cas9-edited rhesus monkeys. Nature Communications2019, 10:5525.

  12. Chao Zhang#, Yang Gao#, Jiaojiao Liu, Zhe Xue, Yan Lu, Lian Deng, Lei Tian, Qidi Feng, Shuhua Xu*.  PGG.Population: a database for understanding the genomic diversity and genetic ancestry of human populations. Nucleic Acids Research2018, 46:D984–D993.

  13. Lei Tian, Asifullah Khan, Zhilin Ning, Kai Yuan, Chao Zhang, Haiyi Lou, Yuan Yuan, Shuhua Xu*. Genome-wide comparison of allele-specific gene expression between African and European populations. Human Molecular Genetics2018, 27(6):1067-1077.

  14. Chao Zhang#, Yan Lu#, Qidi Feng#, Xiaoji Wang#, Haiyi Lou, Jiaojiao Liu, Zhilin Ning, Kai Yuan, Yuchen Wang, Ying Zhou, Lian Deng, Lijun Liu, Yajun Yang, Shilin Li, Lifeng Ma, Zhiying Zhang, Li Jin, Bing Su, Longli Kang, Shuhua Xu*. Differentiated demographic histories and local adaptations between Sherpas and Tibetans. Genome Biology.2017, 18:115.

  15. Qidi Feng#, Yan Lu#, Xumin Ni#, Kai Yuan#, Yajun Yang#, Xiong Yang, Chang Liu, Haiyi Lou, Zhilin Ning, Yuchen Wang, Dongsheng Lu, Chao Zhang, Ying Zhou, Meng Shi, Lei Tian, Xiaoji Wang, Xi Zhang, Jing Li, Asifullah Khan, Yaqun Guan, Kun Tang*, Sijia Wang*, Shuhua Xu*. Genetic history of Xinjiang’s Uyghurs suggests Bronze Age multiple-way contacts in Eurasia. Molecular Biology and Evolution.2017, 34:2572-2582.

  16. Dongsheng Lu, Haiyi Lou, Kai Yuan, Xiaoji Wang, Yuchen Wang, Chao Zhang, Yan Lu, Xiong Yang, Lian Deng, Ying Zhou, Qidi Feng, Ya Hu, Qiliang Ding, Yajun Yang, Shilin Li, Li Jin, Yaqun Guan, Bing Su, Longli Kang, and Shuhua Xu*. Ancestral Origins and Genetic History of Tibetan Highlanders. American Journal of Human Genetics.2016, 99:580-594.

  17. Haiyi Lou, Yan Lu, Dongsheng Lu, Ruiqing Fu, Xiaoji Wang, Qidi Feng, Sijie Wu, Yajun Yang, Shilin Li, Longli Kang, Yaqun Guan, Boon-Peng Hoh, Yeun-Jun Chung, Li Jin, Bing Su, Shuhua Xu*.A 3.4-kb Copy-Number Deletion nearEPAS1Is Significantly Enriched in High-Altitude Tibetans but Absent from the Denisovan Sequence.American Journal of Human Genetics.2015, 97(1):54-66.

  18. Wenfei Jin, Sijia Wang, Haifeng Wang, Li Jin, Shuhua Xu*. Exploring Population Admixture Dynamics Using Empirical and Simulated Genome-Wide Distribution of Ancestral Chromosomal Segments. American Journal of Human Genetics.2012,91:849-862.

  19. Shuhua Xu*, Wenfei Jin. Population Genetics in the Genomic Era (Book Chapter in Population Genetics, Book edited by Dr. Stuart Raleigh, University of Northampton, UK), InTech, Rijeka, Croatia (ISBN 979-953-307-446-6). 2012, Page: 137-168.

  20. Wenfei Jin, Pengfei Qin, Haiyi Lou, Li Jin*, Shuhua Xu*. A Systematic Characterization of Genes Underlying both Complex and Mendelian Diseases. Human Molecular Genetics.2012,21(7):1611-1624.

  21. Shuhua Xu*. Human Population Admixture in Asia. Genomics & Informatics. 201210(2):133-144.

  22. Shuhua Xu*, Shilin Li, Yajun Yang, Jingze Tan, Haiyi Lou, Wenfei Jin, Ling Yang, Xuedong Pan, Jiucun Wang, Yiping Shen, Bailin Wu, Hongyan Wang, Li Jin*. A Genome-Wide Search for Signals of High Altitude Adaptation in Tibetans. Molecular Biology and Evolution. 2011, 28:1003-1011.

  23. Shuhua Xu*, Sanchit Guputa and Li Jin*. PEAS V1.0: A Package for Elementary Analysis of SNP Data. Molecular Ecology Resources. 2010, 10:1085-1088.

  24. The HUGO Pan-Asian SNP Consortium (Li Jin*, Edison T. Liu*, Mark Seielstad*, Shuhua Xu*; 93 authors from 10 countries).Mapping Genetic Diversity in Asia. Science. 2009, 326:1541-1545.