教师基本信息
职称：副教授
办公地点：复旦大学生命科学学院 D503室
办公电话：021-31246571
个人简介
女，博士，副教授，博士研究生导师。1992年获得武汉大学理学学士学位，2003年获得福建师范大学理学硕士学位，2006年获天津科技大学工学博士学位。2006-2008年进入复旦大学生命科学博士后流动站从事研究。2009年至今，复旦大学生命科学学院工作。2013-2014年，多伦多大学医学院，访问学者。主要从事病原微生物分子遗传学的相关研究。
研究方向
应用分子生物学与遗传学、微生物学、生物信息学、免疫学等技术手段，研究结核病相关的细菌毒力机制及其基因调控网络；研究结核潜伏感染过程中病原-宿主互作机制；构建验证新型抗结核BCG疫苗、亚单位疫苗并探索免疫机制。在此基础上发掘结核病分子诊断标识或药物靶标、新型抗结核疫苗。
获奖情况
全国大学生生命科学创新创业大赛，指导教师一等奖。2017年。
代表性论文和论著
1. Jun Jiang#, Chen Lin #,,, Yao Li*, Lu Zhang*, Jun Liu*. 2020. Transcriptome changes of Mycobacterium marinum in the process of resuscitation from hypoxia-induced dormancy. Frontiers in Genetics. 10: 1359.
2. Ding-qianLiu#,,, Lu Zhang*,Qing-zhongWang*. 2020. Over-expression of Tgs1 in Mycobacterium marinum enhances virulence in adult zebrafish. International Journal of Medical Microbiology. 310: 151378.
3. Juntao Mai#,,, Lu Zhang* and Jun Liu*. 2019. Mycobacterium tuberculosis 6C sRNA binds multiple mRNA targets via C-rich loops independent of RNA chaperones. Nucleic Acids Research. 47(8): 4292–4307.
4. Xian Sun#, Lu Zhang#,,, Jun Liu*. 2018. Transcription factors Rv0081 and Rv3334 connect the early and the enduring hypoxic response of Mycobacterium tuberculosis. Virulence. 9(1): 1468–1482.
5. Jing Wu#,,, Lu Zhang* and Jun Liu*. 2017. WhiB4 Regulates the PE/PPE Gene Family and is Essential for Virulence of Mycobacterium marinum. Scientific Reports. 7(1): 3007.
6. Huanwei Ru#,,, Lu Zhang* and Jun Liu*. 2017. The impact of genome region of difference 4 (RD4) on mycobacterial virulence and BCG efficacy. Frontiers in Cellular andInfection Microbiology. 7:239.
7. Zhi-hao Xiang#,,, Lu Zhang* and Jun Liu*. 2017. Immunogenicity and protective efficacy of a fusion protein tuberculosis vaccine combining five Esx family proteins. Frontiers in Cellular and Infection Microbiology. 7:226.
8. Liu Dan#,,, Zhang Lu* and Wang Qingzhong*. 2017. Rv2629 Overexpression Delays Mycobacterium smegmatis and Mycobacteria tuberculosis Entry into Log-Phase and Increases Pathogenicity of Mycobacterium smegmatis in Mice. Frontiers in Microbiology. 8:2231.
9. Lu Zhang#,,, Jun Liu*. 2016. Variable virulence and efficacy of BCG vaccine strains and correlation with genome polymorphisms. Molecular Therapy. 24(2): 398-405.
10. Wen-xi Xu, Lu Zhang*,,, Honghai Wang*. 2014. The Wag31 protein interacts with AccA3 and coordinates cell wall lipid permeability and lipophilic drug resistance in Mycobacterium smegmatis. Biochemical and Biophysical Research Communications. 448: 255–260.
11. Peng Chao, Zhang Lu*,,, Honghai Wang*. 2012. Mtb9.9 protein family: an immunodominant antigen family of Mycobacterium tuberculosis induces humoral and cellular immune responses in mice. Human Vaccines Immunotherapeutics. 8(4): 435-442.
12. Lu Zhang*,,, Honghai Wang*. 2012. Identification of putative biomarkers for the serodiagnosis of drug-resistant Mycobacterium tuberculosis. Proteome Science. DOI: 10.1186/1477-5956-10-12.